Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Charles Yarnall"'
Autor:
Michael G, Katz, Anthony S, Fargnoli, Charles, Yarnall, Angel, Perez, Alice, Isidro, Roger J, Hajjar, Charles R, Bridges
Publikováno v:
The journal of extra-corporeal technology. 50(3)
Cardiopulmonary bypass (CPB) featuring complete heart isolation and continuous cardiac perfusion is a very promising approach for solving the problem of efficient gene delivery. In the technique presented here, separate pumps are used for the systemi
Autor:
Charles Yarnall, Anthony S. Fargnoli, Nury Steuerwald, Hansell H. Stedman, Michael G. Katz, Roger J. Hajjar, Michael Petrov, Richard Hillesheim, Sriparna Ghosh, Charles R. Bridges, Kyle C. Richardville, Richard D. Williams, Alice Isidro, Erik Kohlbrenner
Publikováno v:
The Annals of Thoracic Surgery. 96:586-595
The sarcoplasmic reticulum calcium ATPase (SERCA2a) is an important molecular regulator of contractile dysfunction in heart failure. Gene transfer of SERCA2a mediated by molecular cardiac surgery with recirculating delivery (MCARD) is a novel and cli
Autor:
Joseph J. Rabinowitz, Charles Yarnall, Anthony S. Fargnoli, Charles R. Bridges, Hansell H. Stedman, Michael G. Katz, Marina Sumaroka, Walter J. Koch
Publikováno v:
Journal of Cardiac Failure. 17:691-699
Two major problems for translating gene therapy for heart failure therapy are: safe and efficient delivery and the inability to establish a relationship between vector exposure and in vivo effects. We present a pharmacokinetics (PK) analysis of molec
Autor:
Danielle M. Thesier, Charles Yarnall, Michael G. Katz, R. D. Nolen-Walston, JaBaris D. Swain, Charles R. Bridges, Mihail Petrov, A Henderson, Marina Sumaroka, Catherine E. Tomasulo, Jennifer D. White, Anthony S. Fargnoli, Alice Isidro, Joseph E. Rabinowitz, David E. Holt, Walter J. Koch, Hansell H. Stedman, Lili Wang
Publikováno v:
Gene Therapy. 18:546-552
We use a novel technique that allows for closed recirculation of vector genomes in the cardiac circulation using cardiopulmonary bypass, referred to here as molecular cardiac surgery with recirculating delivery (MCARD). We demonstrate that this platf
Publikováno v:
The Heart Surgery Forum. 10:E428-E430
Minimally invasive surgery for mitral valve disease has been performed using a variety of technologies, some of which are complex, have a steep learning curve, and are expensive. We have adopted a simple cost-effective approach over the last 7 years
Autor:
Mary B. Maher, Charles R. Bridges, Robert B. Norris, Charles Yarnall, John L. Parmet, Alice Isidro, Dapeng Fan
Publikováno v:
The Heart Surgery Forum. 10:E87-E89
We present a biatrial hemangioma in a Jehovah's Witness patient. Hemangioma is extremely rare, accounting for 1% to 2% of benign cardiac tumors. Complete resection of a large hemangioma is mandatory due to its potentially life-threatening risk. In Je
Autor:
Stephane M. Konig, James M. Burkman, Hansell H. Stedman, Timothy J. Gardner, Alan S. Stewart, Mark M. Stecker, Terry Patterson, Haiyan Chen, Charles R. Bridges, Charles Yarnall, Ramin Malekan
Publikováno v:
The Annals of thoracic surgery. 73(6)
Background . The available techniques for intravascular gene delivery to the heart are inefficient and not organ-specific. Yet, effective treatment of heart failure will likely require transgene expression by the majority of cardiac myocytes. To addr
Autor:
John L. Parmet, B. Reddy Dandolu, Patricia Ford, Alice Isidro, Charles Yarnall, Charles R. Bridges, Howard L. Haber
Publikováno v:
The Heart Surgery Forum. 11:E32-E33
Reoperative cardiac surgery in Jehovah's Witness (JW) patients with patent internal mammary arteries is a formidable surgical challenge. We have successfully performed 2 such cases using creative approaches. The first patient, a morbidly obese woman,