Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Charles Y.-F. Young"'
Autor:
Zhongyi Hu, Feng Kong, Manfei Si, Keli Tian, Lin Xi Yu, Charles Y F Young, Huiqing Yuan, Hongxiang Lou
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74387 (2013)
We recently reported that Riccardin D (RD) was able to induce apoptosis by targeting Topo II. Here, we found that RD induced cell cycle arrest in G2/M phase in PC-3 cells, and caused remarkable DNA damage as evidenced by induction of γH2AX foci, mic
Externí odkaz:
https://doaj.org/article/5d5bdbdbacc442bd89df9d268fd71121
Autor:
Yong-Qing Liu, Xiao-Yan Hu, Tao Lu, Yan-Na Cheng, Charles Y F Young, Hui-Qing Yuan, Hong-Xiang Lou
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e38000 (2012)
Previously, we reported that retigeric acid B (RB), a natural pentacyclic triterpenic acid isolated from lichen, inhibited cell growth and induced apoptosis in androgen-independent prostate cancer (PCa) cells. However, the mechanism of action of RB r
Externí odkaz:
https://doaj.org/article/26fc129087f04eff84c54829f7590b86
Publikováno v:
Obstetrics and Gynecology International, Vol 2010 (2010)
The protective effects of fruits, vegetables, and other foods on prostate cancer may be due to their antioxidant properties. An imbalance in the oxidative stress/antioxidant status is observed in prostate cancer patients. Genome oxidative damage in p
Externí odkaz:
https://doaj.org/article/e69910918626433b862cd65c646efa22
Autor:
Charles Y F Young, Meilan He
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 9:395-400
Prostate cancer (PCa) is a common cause of death in men and remains incurable in the androgen-refractory phase. Growing evidence has shown that the androgen receptor (AR) and signal transducers and activators of transcription 3 (STAT3) could be effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05b7f08248d0534ba4918a09fda98d2
https://doi.org/10.2174/1389557510909030395
https://doi.org/10.2174/1389557510909030395
Autor:
Sung Dae, Cho, Cheng, Jiang, Barbara, Malewicz, Yan, Dong, Charles Y F, Young, Kyung-Sun, Kang, Yong-Soon, Lee, Clement, Ip, Junxuan, Lü
Publikováno v:
Molecular Cancer Therapeutics. 3:605-612
Prostate-specific antigen (PSA) is widely used clinically for prostate cancer diagnostics and as an indicator of therapeutic efficacy and recurrence. Several human chemoprevention trials are being conducted to validate the prostate cancer prevention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049a2484f5582588d06ea91625e1becb
https://doi.org/10.1158/1535-7163.605.3.5
https://doi.org/10.1158/1535-7163.605.3.5
Autor:
Pengju, Zhang, Jianye, Zhang, Charles Y F, Young, Pai C, Kao, Weiwen, Chen, Anli, Jiang, Lianying, Zhang, Qiang, Guo
Publikováno v:
Annals of clinical and laboratory science. 35(3)
Chemotherapy, hormonal therapy, or surgery may cause devastating toxic or other side effects. Androgen receptors (ARs) in the cytoplasm are activated by binding with androgen. Androgen-activated ARs bind to a specific genomic DNA sequence, the androg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5c8671aa1f3c8b12bf2f3f383a1675e
https://pubmed.ncbi.nlm.nih.gov/16081584
https://pubmed.ncbi.nlm.nih.gov/16081584
Publikováno v:
Annals of clinical and laboratory science. 33(4)
Recent studies have shown that a single nucleotide polymorphism of A/G substitution in the androgen response element-1 (ARE-1) of the promoter for the prostate-specific antigen gene is a biomarker of prostate cancer. Portugese men with prostate cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::82c20d0fe24c82377306524e43ccf0a2
https://pubmed.ncbi.nlm.nih.gov/14584757
https://pubmed.ncbi.nlm.nih.gov/14584757
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 12(8)
Nonsteroidal anti-inflammatory drugs (NSAIDs) play potential roles in cancer chemoprevention. In this study, we investigated the effects of NSAIDs on androgen receptor (AR)-mediated functions in prostate cancer cells. We found that two cyclooxygenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01e83c915da41805c2d71456d39a74c5
https://pubmed.ncbi.nlm.nih.gov/12917209
https://pubmed.ncbi.nlm.nih.gov/12917209
Publikováno v:
Cancer research. 63(14)
We profiled the expression of genes in benign and untreated human prostate cancer tissues using oligonucleotide microarrays. We report here 50 genes with distinct expression patterns in metastatic and confined tumors (Gleason score 6 and 9; lymph nod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e03dc8d0a3cf5a70c7450cbacb99e40
https://pubmed.ncbi.nlm.nih.gov/12873976
https://pubmed.ncbi.nlm.nih.gov/12873976
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 11(3)
Although a splicing variant of prostate specific antigen (PSA-v) mRNA has been described previously, whether its protein (PSA-v or PSA-related protein 1, i.e., PSA-RP1) is actually expressed in human prostate cells remains elusive. We report that PSA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f062f1edea5683afdbb87752375a34b
https://pubmed.ncbi.nlm.nih.gov/11895882
https://pubmed.ncbi.nlm.nih.gov/11895882