Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Charles W.M. Roberts"'
Autor:
Elaine M. Oberlick, Matthew G. Rees, Brinton Seashore-Ludlow, Francisca Vazquez, Geoffrey M. Nelson, Neekesh V. Dharia, Barbara A. Weir, Aviad Tsherniak, Mahmoud Ghandi, John M. Krill-Burger, Robin M. Meyers, Xiaofeng Wang, Phil Montgomery, David E. Root, Jake M. Bieber, Sandi Radko, Jaime H. Cheah, C. Suk-Yee Hon, Alykhan F. Shamji, Paul A. Clemons, Peter J. Park, Michael A. Dyer, Todd R. Golub, Kimberly Stegmaier, William C. Hahn, Elizabeth A. Stewart, Stuart L. Schreiber, Charles W.M. Roberts
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2331-2344.e8 (2019)
Summary: Cancer is often seen as a disease of mutations and chromosomal abnormalities. However, some cancers, including pediatric rhabdoid tumors (RTs), lack recurrent alterations targetable by current drugs and need alternative, informed therapeutic
Externí odkaz:
https://doaj.org/article/92a087e67b0f487ba84b47b60011a6bf
Autor:
Charles W.M. Roberts, William C. Hahn, Stuart L. Schreiber, Elizabeth A. Stewart, Cory M. Johannessen, Prafulla C. Gokhale, Hong L. Tiv, Lauren Hoffmann, Kaley Blankenship, Burgess B. Freeman, Xiaofeng Wang, Andrew O. Giacomelli, Brinton Seashore-Ludlow, Pilar Ramos, Kaeli M. Mathias, Yiannis Drosos, Hsien-Chao Chou, Guillaume Kugener, Andrew L. Hong, Mariana DoCarmo, Lisa Brenan, Minh-Tam Pham, Taylor E. Arnoff, Matthew G. Rees, Elaine M. Oberlick, Thomas P. Howard
Raw data for follow-up xenograft studies. Note different tabs for each xenograft type.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cf006969ed16c887b51d095fc8b4cf
https://doi.org/10.1158/1078-0432.22476111.v1
https://doi.org/10.1158/1078-0432.22476111.v1
Autor:
Charles W.M. Roberts, William C. Hahn, Loren D. Walensky, Kimberly Stegmaier, Peter J. Park, Prafulla C. Gokhale, Aviad Tsherniak, John M. Krill-Burger, April Cook, Katherine H. Walsh, Justin H. Hwang, Hong L. Tiv, Matthew G. Rees, Elaine M. Oberlick, Guillaume Kugener, Gregory H. Bird, Franziska Wachter, Ann M. Morgan, Minh-Tam Pham, Francisca Vazquez, Su Wang, Neekesh V. Dharia, Andrew L. Hong, Xiaofeng Wang, Andrew O. Giacomelli, Melinda R. Song, Taylor E. Arnoff, Thomas P. Howard
Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to current therapies. In this study, we screened several MRT cell lines with large-scale RNAi, CRISPR-Cas9, and small-molecule libraries to identify potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5e63a84640452290fb3a73f322a7c2
https://doi.org/10.1158/0008-5472.c.6511541.v1
https://doi.org/10.1158/0008-5472.c.6511541.v1
Autor:
Charles W.M. Roberts, William C. Hahn, Stuart L. Schreiber, Elizabeth A. Stewart, Cory M. Johannessen, Prafulla C. Gokhale, Hong L. Tiv, Lauren Hoffmann, Kaley Blankenship, Burgess B. Freeman, Xiaofeng Wang, Andrew O. Giacomelli, Brinton Seashore-Ludlow, Pilar Ramos, Kaeli M. Mathias, Yiannis Drosos, Hsien-Chao Chou, Guillaume Kugener, Andrew L. Hong, Mariana DoCarmo, Lisa Brenan, Minh-Tam Pham, Taylor E. Arnoff, Matthew G. Rees, Elaine M. Oberlick, Thomas P. Howard
Purpose:Rhabdoid tumors are devastating pediatric cancers in need of improved therapies. We sought to identify small molecules that exhibit in vitro and in vivo efficacy against preclinical models of rhabdoid tumor.Experimental Design:We screened eig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea9a68f47fd3df93b1ed379bcbf43b5
https://doi.org/10.1158/1078-0432.c.6529299.v1
https://doi.org/10.1158/1078-0432.c.6529299.v1
Autor:
Charles W.M. Roberts, William C. Hahn, Loren D. Walensky, Kimberly Stegmaier, Peter J. Park, Prafulla C. Gokhale, Aviad Tsherniak, John M. Krill-Burger, April Cook, Katherine H. Walsh, Justin H. Hwang, Hong L. Tiv, Matthew G. Rees, Elaine M. Oberlick, Guillaume Kugener, Gregory H. Bird, Franziska Wachter, Ann M. Morgan, Minh-Tam Pham, Francisca Vazquez, Su Wang, Neekesh V. Dharia, Andrew L. Hong, Xiaofeng Wang, Andrew O. Giacomelli, Melinda R. Song, Taylor E. Arnoff, Thomas P. Howard
Expanded methodological detail on large-scale data analysis (RNAi, CRISPR-Cas9, p53 status annotations, RNA-seq, and primary tumor expression).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f609b17191e1f0d97eeabf7e23b6ca7
https://doi.org/10.1158/0008-5472.22423640
https://doi.org/10.1158/0008-5472.22423640
Autor:
Charles W.M. Roberts, William C. Hahn, Loren D. Walensky, Kimberly Stegmaier, Peter J. Park, Prafulla C. Gokhale, Aviad Tsherniak, John M. Krill-Burger, April Cook, Katherine H. Walsh, Justin H. Hwang, Hong L. Tiv, Matthew G. Rees, Elaine M. Oberlick, Guillaume Kugener, Gregory H. Bird, Franziska Wachter, Ann M. Morgan, Minh-Tam Pham, Francisca Vazquez, Su Wang, Neekesh V. Dharia, Andrew L. Hong, Xiaofeng Wang, Andrew O. Giacomelli, Melinda R. Song, Taylor E. Arnoff, Thomas P. Howard
S1: Sources, media, and other information on all cell lines. S2: p53 status annotations for all cell lines. S3: sgRNA sequences for TP53 inactivation. S4: Primers for TP53 allele screening and RT-qPCR. S5: Sources, catalog numbers, and dilutions of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f07dc29b82807b45137b69ceee2be3
https://doi.org/10.1158/0008-5472.22423637
https://doi.org/10.1158/0008-5472.22423637
Autor:
Charles W.M. Roberts, William C. Hahn, Stuart L. Schreiber, Elizabeth A. Stewart, Cory M. Johannessen, Prafulla C. Gokhale, Hong L. Tiv, Lauren Hoffmann, Kaley Blankenship, Burgess B. Freeman, Xiaofeng Wang, Andrew O. Giacomelli, Brinton Seashore-Ludlow, Pilar Ramos, Kaeli M. Mathias, Yiannis Drosos, Hsien-Chao Chou, Guillaume Kugener, Andrew L. Hong, Mariana DoCarmo, Lisa Brenan, Minh-Tam Pham, Taylor E. Arnoff, Matthew G. Rees, Elaine M. Oberlick, Thomas P. Howard
Combined supplementary figures with accompanying legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477cd833910a34100dbb7c02a3286cc0
https://doi.org/10.1158/1078-0432.22476123
https://doi.org/10.1158/1078-0432.22476123
Autor:
Charles W.M. Roberts, William C. Hahn, Loren D. Walensky, Kimberly Stegmaier, Peter J. Park, Prafulla C. Gokhale, Aviad Tsherniak, John M. Krill-Burger, April Cook, Katherine H. Walsh, Justin H. Hwang, Hong L. Tiv, Matthew G. Rees, Elaine M. Oberlick, Guillaume Kugener, Gregory H. Bird, Franziska Wachter, Ann M. Morgan, Minh-Tam Pham, Francisca Vazquez, Su Wang, Neekesh V. Dharia, Andrew L. Hong, Xiaofeng Wang, Andrew O. Giacomelli, Melinda R. Song, Taylor E. Arnoff, Thomas P. Howard
S1: RNAi data and CRISPR-Cas9 data divided by p53 status. S2: Expression of MDM2 and MDM4 in MRT and control cell lines. S3: CRISPR-Cas9 mediated inactivation of TP53 in MRT cell lines. S4: Immunoblots for p53 pathway activation upon MDM2 and MDM2/4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a151ac00f0d833b79c317c293929d21
https://doi.org/10.1158/0008-5472.22423643.v1
https://doi.org/10.1158/0008-5472.22423643.v1
Autor:
Charles W.M. Roberts, Phuong T.L. Nguyen, Julia A. Evans, Daniel Metzger, Christopher S. Thom, Courtney G. Sansam, Xi Wang
Supplementary Figures 1-3 from Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca66fc9de242deffab67f1984a1017d
https://doi.org/10.1158/0008-5472.22380650.v1
https://doi.org/10.1158/0008-5472.22380650.v1
Autor:
Charles W.M. Roberts, Phuong T.L. Nguyen, Julia A. Evans, Daniel Metzger, Christopher S. Thom, Courtney G. Sansam, Xi Wang
Alterations in chromatin play an important role in oncogenic transformation, although the underlying mechanisms are often poorly understood. The SWI/SNF complex contributes to epigenetic regulation by using the energy of ATP hydrolysis to remodel chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf9b1f48c2f67841cf4aae85f052662
https://doi.org/10.1158/0008-5472.c.6499631.v1
https://doi.org/10.1158/0008-5472.c.6499631.v1