Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charles W. Tran"'
Autor:
SeongJun Han, Douglas C. Chung, Michael St. Paul, Zhe Qi Liu, Carlos Garcia-Batres, Alisha R. Elford, Charles W. Tran, Laurence Chapatte, Pamela S. Ohashi
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Regulatory T cells are integral to the regulation of autoimmune and anti-tumor immune responses. However, several studies have suggested that changes in T cell signaling networks can result in T cells that are resistant to the suppressive effects of
Externí odkaz:
https://doaj.org/article/7620cdae7f0340628f2a299d5ba2512d
Autor:
Yan Qu, Ira Mellman, Ellen Duong, Thomas D Wu, Eugene Y Chiang, Katherine Nutsch, Karl L Banta, Charles W Tran, Stephanie Mittman, Barzin Y Nabet, Namrata S Patil
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/5a68ddaf764c4d40afd06e0a458c6d04
Autor:
William Lu, James Byers, Charles W. Tran, Michal Mass, Tanu Shenoy, Shirley Sun, Kyle Jacoby, Stefanie Mandl
Publikováno v:
Cancer Research. 82:2827-2827
PACT Pharma has developed a robust single-step, targeted, non-viral method for the manufacturing of personalized adoptive cells therapies for the treatment of solid cancers (NCT03970382). For this, we insert and express a neoepitope-specific T cell r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4beed83c1b3f513d05143d3f07af765
https://doi.org/10.1158/1538-7445.am2022-2827
https://doi.org/10.1158/1538-7445.am2022-2827
Autor:
Charles W. Tran, Kayla Lee, Bhamini Purandare, James Byers, Michael M. Dubreuil, William Lu, Michal Mass, Kyle Jacoby, Stefanie J. Mandl, Barbara Sennino
Publikováno v:
Cancer Research. 82:2829-2829
Personalized autologous TCR-T cell therapies targeting neoepitopes (neoE) derived from tumor-specific mutations are a compelling approach for the treatment of patients with solid tumors. Using the ultra-sensitive imPACT Isolation Technology®, antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d68b648e89d9c6263aa0e79317809d3d
https://doi.org/10.1158/1538-7445.am2022-2829
https://doi.org/10.1158/1538-7445.am2022-2829
Autor:
Andrew J. Elia, Matthew J. Gold, Carlos Garcia-Batres, Megan E Himmel, Kelly Tai, Alisha R. Elford, Pamela S. Ohashi, Charles W. Tran
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0244366 (2020)
PLoS ONE, Vol 15, Iss 12, p e0244366 (2020)
Dendritic cells are sentinels of the immune system and represent a key cell in the activation of the adaptive immune response. Hypoxia-inducible factor 1 alpha (HIF-1α)–a crucial oxygen sensor stabilized during hypoxic conditions–has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8275bbfa2a0355d8b5514030e7dfd554
http://europepmc.org/articles/PMC7775062
http://europepmc.org/articles/PMC7775062
Autor:
Charles W. Tran, SeongJun Han, Alisha R. Elford, Pamela S. Ohashi, Carlos Garcia-Batres, Michael St. Paul, Laurence Chapatte, Zhe Qi Liu, Douglas C. Chung
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Regulatory T cells are integral to the regulation of autoimmune and anti-tumor immune responses. However, several studies have suggested that changes in T cell signaling networks can result in T cells that are resistant to the suppressive effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494b37c27fbefe1e540c7635b4789d2f
https://doaj.org/article/7620cdae7f0340628f2a299d5ba2512d
https://doaj.org/article/7620cdae7f0340628f2a299d5ba2512d
Autor:
Shawn Stapleton, Ali Vedadi, Michael Milosevic, Matthew J. Gold, Christine Allen, David A. Jaffray, Charles W. Tran, Trevor D. McKee, Michael Dunne, Pamela S. Ohashi
Publikováno v:
ACS Nano. 12:7583-7600
Nanomedicine drug delivery systems are capable of transporting significant payloads to solid tumors. However, only a modest increase in antitumor efficacy relative to the standard of care has been observed. In this study, we demonstrate that a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf24a5001be6d58290d88757c519239f
https://doi.org/10.1021/acsnano.7b06301
https://doi.org/10.1021/acsnano.7b06301
Autor:
Michael St. Paul, Samuel D. Saibil, SeongJun Han, Kavita Israni-Winger, Scott C. Lien, Rob C. Laister, Azin Sayad, Susanne Penny, Rodabe N. Amaria, Lauren E. Haydu, Carlos R. Garcia-Batres, Meghan Kates, David T. Mulder, Céline Robert-Tissot, Matthew J. Gold, Charles W. Tran, Alisha R. Elford, Linh T. Nguyen, Trevor J. Pugh, Devanand M. Pinto, Jennifer A. Wargo, Pamela S. Ohashi
Publikováno v:
Cell Metabolism. 33:2415-2427.e6
Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study the metabolic pathways associated with increased anti-tumor T cell function, we utilized a metabolomics approach to characterize three different CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7863287b3155fd42a888480b87c4d92
https://doi.org/10.1016/j.cmet.2021.11.010
https://doi.org/10.1016/j.cmet.2021.11.010
Autor:
Kelly Tai, Mitchell G. Vainberg, Tak W. Mak, Han You, Josef M. Penninger, Michael E. Parsons, James R. Woodgett, Amy E. Lin, Sara R. Hamilton, Kristine M. Garza, Karl S. Lang, Alisha R. Elford, Kip Wigmore, Charles W. Tran, Thierry Le Bihan, Samuel D. Saibil, Pamela S. Ohashi
Publikováno v:
The Journal of Immunology. 199:4056-4065
The decision between T cell activation and tolerance is governed by the spatial and temporal integration of diverse molecular signals and events occurring downstream of TCR and costimulatory or coinhibitory receptor engagement. The PI3K–protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba0b8e31e661bcc16210805dd5e742a
https://doi.org/10.4049/jimmunol.1600396
https://doi.org/10.4049/jimmunol.1600396
Autor:
Stefanie Mandl, Kyle Jacoby, Michael M. Dubreuil, Alex Franzusoff, Barbara Sennino, Charles W. Tran, Bhamini Purandare, James Byers, William Lu, Michal Mass
Publikováno v:
Cancer Research. 81:1526-1526
Personalized autologous TCR-T cell therapies targeting neoE-specific neoepitopes (NeoE) derived from tumor-exclusive mutations are a compelling approach for the treatment of patients with solid tumors. Using the ultra-sensitive imPACT Isolation Techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b657b854efdd82c9e806bde73895f6
https://doi.org/10.1158/1538-7445.am2021-1526
https://doi.org/10.1158/1538-7445.am2021-1526