Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Charles W. Riggs"'
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 22:329-334
In a previous study, treatment of rats with 10% glucose in the drinking water, as fetuses during gestation and for 1.5 months after delivery, significantly enhanced tumor incidence that resulted from N-methyl-N-nitrosourea (MNU, 20 mg/kg) given trans
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 478:51-63
Somatic cells of whole Syrian hamster fetuses (gestation day 13) were isolated and tested by an in vivo/in vitro mutation assay for spontaneous mutation frequencies using independent 6-thioguanine (6-TG), diphtheria toxin (DT), and ouabain mutation s
Autor:
Bhalchandra A. Diwan, Jerry M. Rice, Daniel Logsdon, Ann B. Jones, Miriam C. Poirier, Chaoyu Wang, Stuart H. Yuspa, Charles W. Riggs, Ofelia A. Olivero, Thomas J. Moskal, Steven W. Harbaugh, Lucy M. Anderson, Diana C. Haines
Publikováno v:
JNCI Journal of the National Cancer Institute. 89:1602-1608
Background: When given during pregnancy, the drug 3'-azido-2',3'-dideoxy-thymidine (AZT) substantially reduces maternal-fetal transmission of human immunodeficiency virus type 1 (HIV-1). However, AZT has been shown to be carcinogenic in adult mice af
Autor:
Sally E. Spence, Susanna M. Rybak, Stanislaw M. Mikulski, William E. Fogler, John W. Pearson, Dianne L. Newton, Kirk Volker, Charles W. Riggs, Wojciech Ardelt, Dan L. Longo, Hsiang-Fu Kung
Publikováno v:
JNCI: Journal of the National Cancer Institute. 88:747-753
Background : Onconase, a protein isolated from oocytes and early embryos of the frog Rana pipiens, shares extensive homology with bovine pancreatic ribonuclease (RNase A) and possesses similar enzyme activity. Onconase is cytotoxic toward cancer cell
Autor:
Bhalchandra A. Diwan, Ricardo E. Rodriguez, Kazimierz S. Kasprzak, Manoj Misra, Charles W. Riggs
Publikováno v:
Toxicology. 107:131-140
The aim of this study was to compare susceptibility of mice of different strains to the toxicity and carcinogenicity of nickel subsulfide (Ni3S2), a water insoluble compound suspected to damage cells through oxidative mechanisms. Groups of 30 male mi
Autor:
Charles W. Riggs, Dan L. Longo, William E. Fogler, John W. Pearson, Hirotsugu Watabe, Kirk Volker, Robert H. Wiltrout, Keiko Ariyoshi
Publikováno v:
JNCI Journal of the National Cancer Institute. 87:94-103
BACKGROUND The anti-P-glycoprotein monoclonal antibody MRK-16 mediates the reversal of multidrug resistance. Recombinant human interferon alfa (rHuIFN alpha) enhances the cytotoxic activity of diverse chemotherapeutics and may modulate multidrug resi
Publikováno v:
Journal of Toxicology and Environmental Health. 39:527-538
The incidence of a set of neoplasms arising "spontaneously" in Fischer 344 (F344) rats was determined in control and carcinogen-treated animals. Data were obtained from approximately 9000 rats (4000 males and 5000 females) used to study the carcinoge
Autor:
Yooson E. Kim, Lucy M. Anderson, Robert M. Kovatch, Shantu Amin, Lisa E. Beebe, Charles W. Riggs
Publikováno v:
Carcinogenesis. 14:1545-1548
We have previously shown a positive tumor-promoting effect of a single dose of Aroclor 1254 on lung and liver tumors initiated neonatally in the mouse by N-nitrosodimethylamine (NDMA). In this study, we have confirmed and extended this observation wi
Autor:
Charles W. Riggs, Bhalchandra A. Diwan, Manoj Misra, Jerry M. Rice, Miral Dizdaroglu, Ryszard Olinski, Kazimierz S. Kasprzak
Publikováno v:
Chemical Research in Toxicology. 5:809-815
DNA base damage was studied in renal and hepatic chromatin of nickel(II)-injected pregnant female F344/NCr rats and their fetuses under conditions leading to initiation of sodium barbital-promotable renal tumors, but not liver tumors, in the male off
Publikováno v:
Pharmacology & Toxicology. 69:178-188
Foetal mice of genotype AhbAhd (responsive to induction of metabolism of polycyclic aromatic hydrocarbons [PAH]) or AhdAhd (non-responsive) were exposed transplacentally on gestation day 17 to a single dose of 3-methylcholanthrene (MC, 5-175 mg/kg) w