Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Charles W. Locuson"'
Autor:
Charles W. Locuson, David C. Rankin, Kate S. KuKanich, Butch KuKanich, Marissa S Komp, Peter Cho, Alyson H. Fitzgerald
Publikováno v:
American Journal of Veterinary Research. 82:171-180
OBJECTIVE To assess the pharmacokinetics and opioid effects of methadone after administration of multiple doses by means of 2 dosing regimens of methadone-fluconazole-naltrexone. ANIMALS 12 healthy Beagles. PROCEDURES Dogs were randomly allocated (6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16905c087995b45366d066a9693347a
https://doi.org/10.2460/ajvr.82.3.171
https://doi.org/10.2460/ajvr.82.3.171
Publikováno v:
American Journal of Veterinary Research. 81:656-664
OBJECTIVE To determine the effects of coadministration of naltrexone, a human opioid abuse deterrent, on the pharmacokinetics and pharmacodynamics of a methadone-fluconazole combination administered orally to dogs. ANIMALS 12 healthy Beagles. PROCEDU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fab13c5431ac79768d7692b239430d
https://doi.org/10.2460/ajvr.81.8.656
https://doi.org/10.2460/ajvr.81.8.656
Autor:
Kellie D. Nance, Colleen M. Niswender, Christopher J. Langmead, Aaron M. Bender, Hyekyung P. Cho, Karl R. Voigtritter, P. Jeffrey Conn, Carrie K. Jones, Thomas M. Bridges, Sichen Chang, Patrick R. Gentry, Vincent B. Luscombe, Kaelyn S. Lingenfelter, Alice E. Berizzi, Jordan C. O’Neill, Craig W. Lindsley, Arthur Christopoulos, Charles W. Locuson, Patrick M. Sexton, Xiaoyan Zhan
Publikováno v:
ACS Chemical Neuroscience. 9:1572-1581
The pharmacology of the M5 muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the optimization effort a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16e38b3b033988bef5ccd6f3c551fb2
https://doi.org/10.1021/acschemneuro.8b00126
https://doi.org/10.1021/acschemneuro.8b00126
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics
Meloxicam is a cyclooxygenase (COX) inhibitor with a higher selectivity for cyclooxygenase‐2 (COX‐2) than for cyclooxygenase‐1 (COX‐1). In the laboratory setting, this nonsteroidal anti‐inflammatory drug (NSAID) is commonly selected for ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8485bdfb5dbdcde1a308c682aa7fc45a
https://doi.org/10.1111/jvp.12297
https://doi.org/10.1111/jvp.12297
Autor:
Aaron M, Bender, Hyekyung P, Cho, Kellie D, Nance, Kaelyn S, Lingenfelter, Vincent B, Luscombe, Patrick R, Gentry, Karl, Voigtritter, Alice E, Berizzi, Patrick M, Sexton, Christopher J, Langmead, Arthur, Christopoulos, Charles W, Locuson, Thomas M, Bridges, Sichen, Chang, Jordan C, O'Neill, Xiaoyan, Zhan, Colleen M, Niswender, Carrie K, Jones, P Jeffrey, Conn, Craig W, Lindsley
Publikováno v:
ACS chemical neuroscience. 9(7)
[Image: see text] The pharmacology of the M(5) muscarinic acetylcholine receptor (mAChR) is the least understood of the five mAChR subtypes due to a historic lack of selective small molecule tools. To address this shortcoming, we have continued the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::591af45d955d6d8ab49f9660a56fee9a
https://pubmed.ncbi.nlm.nih.gov/29678111
https://pubmed.ncbi.nlm.nih.gov/29678111
Autor:
Colleen M. Niswender, Hyekyung P. Cho, Jerri M. Rook, Anna L. Blobaum, P. Jeffrey Conn, Pedro M. Garcia-Barrantes, Zixiu Xiang, Craig W. Lindsley, Charles W. Locuson, Frank W. Byers
Publikováno v:
Journal of Medicinal Chemistry. 58:7959-7971
The therapeutic potential of selective mGlu1 activation is vastly unexplored relative to the other group I mGlu receptor, mGlu5; therefore, our lab has focused considerable effort toward developing mGlu1 positive allosteric modulators (PAMs) suitable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9d97135413b3641c0954a7303c19cc
https://doi.org/10.1021/acs.jmedchem.5b00727
https://doi.org/10.1021/acs.jmedchem.5b00727
Autor:
Thomas M. Bridges, P. Jeffrey Conn, Craig W. Lindsley, Charles W. Locuson, J. Scott Daniels, Frank W. Byers, Anna L. Blobaum
Publikováno v:
Drug Metabolism and Disposition. 43:1718-1726
Once thought to be an artifact of microsomal systems, atypical kinetics with cytochrome P450 (CYP) enzymes have been extensively investigated in vitro and found to be substrate and species dependent. Building upon increasing reports of heterotropic C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d3014a6173d3ff067d07c04357f37d
https://doi.org/10.1124/dmd.115.064006
https://doi.org/10.1124/dmd.115.064006
Autor:
Michael Bubser, C.K. Jones, Charles W. Locuson, Robert W. Gould, Ditte Dencker, Xiaoyan Zhan, Zixiu Xiang, Michael Grannan, Craig W. Lindsley, P.J. Conn, Jürgen Wess
Publikováno v:
ACS Chemical Neuroscience. 6:1683-1695
The M1 muscarinic acetylcholine receptor (mAChR) subtype has been implicated in the underlying mechanisms of learning and memory and represents an important potential pharmacotherapeutic target for the cognitive impairments observed in neuropsychiatr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5ecf0d476af60e6a37af80237fd256
https://doi.org/10.1021/acschemneuro.5b00123
https://doi.org/10.1021/acschemneuro.5b00123
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 39:122-130
The dog CYP1A2 enzyme is likely an important contributor to the metabolism of veterinary drugs. Dog CYP1A2 is expressed in liver, plus it is inducible and polymorphic, creating the potential for intersubject differences in pharmacokinetics. Hence, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aca266f7fdfc867b21ffe0d05883d1f
https://doi.org/10.1111/jvp.12256
https://doi.org/10.1111/jvp.12256
Publikováno v:
Xenobiotica. 45:495-502
1. Cattle are an important component of the human food chain. Drugs used either legally or illegally in cattle may therefore enter the food chain and it is thus important to understand pathways of drug metabolism in this species, including sulfation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b477a14bda5af9cda24cdecb5fb213f6
https://doi.org/10.3109/00498254.2014.997325
https://doi.org/10.3109/00498254.2014.997325