Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Charles W. Dobard"'
Autor:
Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava, Panita Maturavongsadit, Alka Prasher, Andres Wong-Sam, Chuong Dinh, Tiancheng Edwards, Victoria Mrotz, James Mitchell, Josilene Nascimento Seixas, Aryani Pallerla, Allison Thorson, Amanda Schauer, Craig Sykes, Gabriela De la Cruz, Stephanie A. Montgomery, Angela D. M. Kashuba, Walid Heneine, Charles W. Dobard, Martina Kovarova, J. Victor Garcia, J. Gerardo Garcίa-Lerma, S. Rahima Benhabbour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administe
Externí odkaz:
https://doaj.org/article/8c9e1df2e9064777a30af13581288fca
Autor:
Ivana Massud, Kenji Nishiura, Susan Ruone, Angela Holder, Chuong Dinh, Jonathan Lipscomb, James Mitchell, George M. Khalil, Walid Heneine, J. Gerardo Garcίa-Lerma, Charles W. Dobard
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 384 (2024)
Pre-exposure prophylaxis (PrEP) with a weekly oral regimen of antiretroviral drugs could be a suitable preventative option for individuals who struggle with daily PrEP or prefer not to use long-acting injectables. We assessed in macaques the efficacy
Externí odkaz:
https://doaj.org/article/a522a275318c403b8197fc61f71923cd
Autor:
Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava, Panita Maturavongsadit, Alka Prasher, Andres Wong-Sam, Chuong Dinh, Tiancheng Edwards, Victoria Mrotz, James Mitchell, Josilene Nascimento Seixas, Aryani Pallerla, Allison Thorson, Amanda Schauer, Craig Sykes, Gabriela De la Cruz, Stephanie A. Montgomery, Angela D. M. Kashuba, Walid Heneine, Charles W. Dobard, Martina Kovarova, J. Victor Garcia, J. Gerardo Garcίa-Lerma, S. Rahima Benhabbour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6a18aab38ad64106a8e0e7466f66fcbe
Autor:
Michele B. Daly, Andres Wong-Sam, Linying Li, Archana Krovi, Gregory J. Gatto, Chasity Norton, Ellen H. Luecke, Victoria Mrotz, Catalina Forero, Mackenzie L. Cottrell, Amanda P. Schauer, Joy Gary, Josilene Nascimento-Seixas, James Mitchell, Ariane van der Straten, Walid Heneine, J. Gerardo Garcίa-Lerma, Charles W. Dobard, Leah M. Johnson
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2676 (2023)
The prevention of HIV and unintended pregnancies is a public health priority. Multi-purpose prevention technologies capable of long-acting HIV and pregnancy prevention are desirable for women. Here, we utilized a preclinical macaque model to evaluate
Externí odkaz:
https://doaj.org/article/3ac783c0b3c04b168eab70e7aa6df9d0
Autor:
Charles W. Dobard, M. Melissa Peet, Kenji Nishiura, Angela Holder, Chuong Dinh, James Mitchell, George Khalil, Yi Pan, Onkar N. Singh, Timothy J. McCormick, Vivek Agrahari, Pardeep Gupta, Sriramakamal Jonnalagadda, Walid Heneine, Meredith R. Clark, J. Gerardo García-Lerma, Gustavo F. Doncel
Publikováno v:
EBioMedicine, Vol 86, Iss , Pp 104361- (2022)
Summary: Background: Vaginal products for HIV prevention that can be used on-demand before or after sex may be a preferable option for women with low frequency or unplanned sexual activity or who prefer not to use daily or long-acting pre-exposure pr
Externí odkaz:
https://doaj.org/article/55d8031cbca74a5682878f9dfe8e5255
Autor:
Kunal Jhunjhunwala, Charles W. Dobard, Sunita Sharma, Natalia Makarova, Angela Holder, Chuong Dinh, James Mitchell, Lin Wang, Junmei Zhang, Sravan Kumar Patel, Walid Heneine, Lisa C. Rohan
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1110 (2021)
Receptive anal intercourse (RAI) contributes significantly to HIV acquisition underscoring the need to develop HIV prevention options for populations engaging in RAI practices. We explored the feasibility of formulating rectal suppositories with pote
Externí odkaz:
https://doaj.org/article/3ac71f755747494c80bf422307adebd9
Autor:
Charles W. Dobard, M. Melissa Peet, Kenji Nishiura, Angela Holder, Chuong Dinh, James Mitchell, George Khalil, Yi Pan, Onkar N. Singh, Timothy J. McCormick, Vivek Agrahari, Pardeep Gupta, Sriramakamal Jonnalagadda, Walid Heneine, Meredith R. Clark, J. Gerardo Garcia-Lerma, Gustavo F. Doncel
Publikováno v:
SSRN Electronic Journal.
Vaginal products for HIV prevention that can be used on-demand before or after sex may be a preferable option for women with low frequency or unplanned sexual activity or who prefer not to use daily or long-acting pre-exposure prophylaxis (PrEP). We
Publikováno v:
Journal of Virology. 81:10037-10046
Reverse transcriptase (RT) and integrase (IN) are two essential enzymes that play a critical role in synthesis and integration of the retroviral cDNA, respectively. For human immunodeficiency virus type 1 (HIV-1), RT and IN physically interact and ce
After membrane fusion with a target cell, the core of human immunodeficiency virus type 1 (HIV-1) enters into the cytoplasm, where uncoating occurs. The cone-shaped core is composed of the viral capsid protein (CA), which disassembles during uncoatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c060ea36cee3ccacb2b747f6873b56a
https://europepmc.org/articles/PMC2863833/
https://europepmc.org/articles/PMC2863833/
Publikováno v:
Journal of virology. 78(10)
Retroviral integrase catalyzes the essential step of integrating a double-stranded DNA copy of the viral genome into a host cell chromosome. Mutational studies have revealed that integrase is involved in additional steps of viral replication, but the