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Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist
Autor:
Drake S. Eggleston, Angela S. Wong, Andrew J. Nichols, Chuan-Kui Yuan, R. Curtis Haltiwanger, William E. Bondinell, Paul F. Koster, William H. Miller, Joseph W. Venslavsky, William F. Huffman, Karl F. Erhard, S M Hwang, Janice A. Vasko-Moser, Thomas W. Ku, Chao Pin Lee, Stephen T. Ross, Dalia R. Jakas, Richard M. Keenan, J. Samanen, Richard E. Valocik, Charles W. De Brosse, Fadia E. Ali, Andrew Allen
Publikováno v:
Bioorganicmedicinal chemistry. 2(9)
The direct design of the potent nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist, 8-[[[4- (aminoiminomethyl)phenyl]amino]carbonyl]-2,3,4,5-tetrahydro-3-oxo- 4- (2-phenylethyl)-1H-1,4-benzodiazepine-2-acetic acid, (3) (SB 207448), based