Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Charles W. Bugg"'
Autor:
Charles W. Bugg, Kristin Berona
Publikováno v:
Western Journal of Emergency Medicine, Vol 17, Iss 3, Pp 383-383 (2016)
Externí odkaz:
https://doaj.org/article/935b9d59b6594217a9d95cc8c998d445
Autor:
Amber L Southwell, Charles W Bugg, Linda S Kaltenbach, Denise Dunn, Stefanie Butland, Andreas Weiss, Paolo Paganetti, Donald C Lo, Paul H Patterson
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16676 (2011)
Proteolytic processing of mutant huntingtin (mHtt), the protein that causes Huntington's disease (HD), is critical for mHtt toxicity and disease progression. mHtt contains several caspase and calpain cleavage sites that generate N-terminal fragments
Externí odkaz:
https://doaj.org/article/83d61df88355459e91c3326b3f7f65cd
Autor:
Kristin Berona, Charles W. Bugg
Publikováno v:
Western Journal of Emergency Medicine
Bugg, Charles W.; & Berona, Kristin. (2016). Point-of-Care Ultrasound Diagnosis of Left-Sided Endocarditis. Western Journal of Emergency Medicine, 17(3). doi: 10.5811/westjem.2016.2.29921. Retrieved from: http://www.escholarship.org/uc/item/0h24g3jt
Western Journal of Emergency Medicine, Vol 17, Iss 3, Pp 383-383 (2016)
Bugg, Charles W.; & Berona, Kristin. (2016). Point-of-Care Ultrasound Diagnosis of Left-Sided Endocarditis. Western Journal of Emergency Medicine, 17(3). doi: 10.5811/westjem.2016.2.29921. Retrieved from: http://www.escholarship.org/uc/item/0h24g3jt
Western Journal of Emergency Medicine, Vol 17, Iss 3, Pp 383-383 (2016)
A 56-year-old male presented to the emergency department (ED) with fatigue, generalized weakness, cough without hemoptysis or dyspnea, occasional fever, night sweats, dark stools, and weight loss for months. Physical exam revealed a cachectic gentlem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b209c5bfbffb53190db50c475a00d1
https://pubmed.ncbi.nlm.nih.gov/27330676
https://pubmed.ncbi.nlm.nih.gov/27330676
Publikováno v:
The Journal of biological chemistry. 287(38)
Misfolding and aggregation of huntingtin is one of the hallmarks of Huntington disease, but the overall structure of these aggregates and the mechanisms by which huntingtin misfolds remain poorly understood. Here we used site-directed spin labeling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf0f6e54cb6b1b7e59de4b5d007cbf6
https://pubmed.ncbi.nlm.nih.gov/22801429
https://pubmed.ncbi.nlm.nih.gov/22801429
Autor:
Amber L. Southwell, Paul H. Patterson, Donald C. Lo, Charles W. Bugg, Stefanie L. Butland, Denise E. Dunn, Linda S. Kaltenbach, Paolo Paganetti, Andreas Weiss
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e16676 (2011)
PLoS ONE, Vol 6, Iss 1, p e16676 (2011)
Background: Proteolytic processing of mutant huntingtin (mHtt), the protein that causes Huntington's disease (HD), is critical for mHtt toxicity and disease progression. mHtt contains several caspase and calpain cleavage sites that generate N-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e194af4652e029128b4e5c3291e1cbcc
https://resolver.caltech.edu/CaltechAUTHORS:20110317-142922950
https://resolver.caltech.edu/CaltechAUTHORS:20110317-142922950
Autor:
Amber L. Southwell, Charles W. Bugg, Paul H. Patterson, Ali Khoshnan, Denise E. Dunn, Donald C. Lo
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(36)
Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected. The polyQ expansion that causes Huntington's disease (HD) is in the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7a3ac0c5252bdbac10d4b8331c2b65
https://pubmed.ncbi.nlm.nih.gov/18768695
https://pubmed.ncbi.nlm.nih.gov/18768695
Autor:
Bugg, Charles W.1 wally.bugg@gmail.com, Berona, Kristin1
Publikováno v:
Western Journal of Emergency Medicine: Integrating Emergency Care with Population Health. May2016, Vol. 17 Issue 3, p383-383. 1p.
Autor:
Donald C. Lo, Robert E. Hughes
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and