Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Charles W M Roberts"'
Autor:
Priya Mittal, Jacquelyn A. Myers, Raymond D. Carter, Sandi Radko-Juettner, Hayden A. Malone, Wojciech Rosikiewicz, Alexis N. Robertson, Zhexin Zhu, Ishwarya V. Narayanan, Baranda S. Hansen, Meadow Parrish, Natarajan V. Bhanu, Robert J. Mobley, Jerold E. Rehg, Beisi Xu, Yiannis Drosos, Shondra M. Pruett-Miller, Mats Ljungman, Benjamin A. Garcia, Gang Wu, Janet F. Partridge, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in nearly 25% of cancers. To gain insight into the mechanisms by which SWI/SNF mutations drive cancer, we contributed ten rhabdoid tumor (RT) cell lines muta
Externí odkaz:
https://doaj.org/article/fb1fbd9e73e346ad922fc3783cc2f771
Autor:
Simon Wöhrle, Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami, Zainab Jagani, Anne Thuery, Beatrice Bauer-Probst, Flavia Reimann, Christelle Stamm, Astrid Pornon, Vincent Romanet, Vito Guagnano, Thomas Brümmendorf, William R Sellers, Francesco Hofmann, Charles W M Roberts, Diana Graus Porta
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)
Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1. MRTs are poorly responsive to chemotherapy and thus a high unmet clinic
Externí odkaz:
https://doaj.org/article/5ddabf7e37d840fe9ce647ad449900b5
Autor:
Zhexin Zhu, Xiaolong Chen, Ao Guo, Trishabelle Manzano, Patrick J. Walsh, Kendall M. Wills, Rebecca Halliburton, Sandi Radko-Juettner, Raymond D. Carter, Janet F. Partridge, Douglas R. Green, Jinghui Zhang, Charles W. M. Roberts
Publikováno v:
Nature. 618:180-187
Autor:
Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aaron Ross, Francisca Vazquez, William C. Hahn, Peter J. Park, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Mutations of the SWI/SNF chromatin-remodeling complex member SMARCB1 can cause malignant rhaboid tumors. Here the authors report a BRD9-containing SWI/SNF subcomplex that lacks SMARCB1 and its requirement for the survival of rhaboid tumors.
Externí odkaz:
https://doaj.org/article/4b69173f717e4efcb19c2a38dcdb58fd
Autor:
Burak H. Alver, Kimberly H. Kim, Ping Lu, Xiaofeng Wang, Haley E. Manchester, Weishan Wang, Jeffrey R. Haswell, Peter J. Park, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
SWI/SNF chromatin remodelling complex is a major regulator of chromatin structure and of transcription. Here, using mouse embryonic fibroblasts and human rhabdoid tumour cells, the authors provide evidence that SWI/SNF functions as a regulator of enh
Externí odkaz:
https://doaj.org/article/987848cfa7004d11b8b1c3154bd8c459
Autor:
Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
Publikováno v:
Nature. 607:135-141
Autor:
Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton, Alykhan F. Shamji, Carlos Rodriguez-Galindo, Katherine A. Janeway, Charles W. M. Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J. Cima, Robert S. Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, William C. Hahn, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomi
Externí odkaz:
https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db
Autor:
Robert J. Mobley, Jacquelyn A. Myers, Kendall M. Wills, Hayden A. Malone, Trishabelle I. Manzano, Janet F. Partridge, Charles W. M. Roberts
Genes encoding subunits of SWI/SNF (BAF) chromatin remodeling complexes are mutated in >20% of cancers. SWI/SNF complexes exist in three distinct families that each contribute to regulation of transcription, although the functional interactions betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a260e2f85bdf6cb485a6642a86b268d
https://doi.org/10.1101/2022.08.07.503080
https://doi.org/10.1101/2022.08.07.503080
Autor:
Francisca Vazquez, Iris Fung, Aviad Tsherniak, Thomas P. Howard, Brenton R. Paolella, Adam D. Durbin, Pratiti Bandopadhayay, Allison Warren, Charles W. M. Roberts, Andrew Tang, Andrew L. Hong, Clare F. Malone, James M. McFarland, Joshua M. Dempster, William C. Hahn, John M. Krill-Burger, Phoebe Moh, Caroline Wechsler, Lillian M. Guenther, Jesse S. Boehm, Philip Montgomery, Guillaume Kugener, Nishant Jha, Neekesh V. Dharia, Todd R. Golub, Kimberly Stegmaier
Publikováno v:
Nature genetics
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known for remarkably few mutat
Autor:
Xiaofeng Wang, Su Wang, Emma C. Troisi, Thomas P. Howard, Jeffrey R. Haswell, Bennett K. Wolf, William H. Hawk, Pilar Ramos, Elaine M. Oberlick, Evgeni P. Tzvetkov, Aaron Ross, Francisca Vazquez, William C. Hahn, Peter J. Park, Charles W. M. Roberts
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/18b73f82f0e648d5964d49583e0eeb78