Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Charles V Mobbs"'
Autor:
Cesar L Moreno, Linda Yang, Penny A Dacks, Fumiko Isoda, Jan M A van Deursen, Charles V Mobbs
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166381 (2016)
We have reported a correlation between hypothalamic expression of Creb-binding protein (Cbp) and lifespan, and that inhibition of Cbp prevents protective effects of dietary restriction during aging, suggesting that hypothalamic Cbp plays a role in re
Externí odkaz:
https://doaj.org/article/5860959c15674cc582f033695ca9b5e1
Autor:
Michal M Poplawski, Jason W Mastaitis, Fumiko Isoda, Fabrizio Grosjean, Feng Zheng, Charles V Mobbs
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18604 (2011)
Intensive insulin therapy and protein restriction delay the development of nephropathy in a variety of conditions, but few interventions are known to reverse nephropathy. Having recently observed that the ketone 3-beta-hydroxybutyric acid (3-OHB) red
Externí odkaz:
https://doaj.org/article/67095abbf0624f78a7325fd2fc1eae20
Autor:
Minhua Zhang, Michal Poplawski, Kelvin Yen, Hui Cheng, Erik Bloss, Xiao Zhu, Harshil Patel, Charles V Mobbs
Publikováno v:
PLoS Biology, Vol 7, Iss 11, p e1000245 (2009)
How dietary restriction (DR) increases lifespan and decreases disease burden are questions of major interest in biomedical research. Here we report that hypothalamic expression of CREB-binding protein (CBP) and CBP-binding partner Special AT-rich seq
Externí odkaz:
https://doaj.org/article/2d7a20c9f7f94093bc8099468aa80e5d
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Since the development of antibiotics and vaccination, as well as major improvements in public hygiene, the main risk factors for morbidity and mortality are age and chronic exposure to environmental factors, both of which can interact with genetic pr
Externí odkaz:
https://doaj.org/article/a58b4358832b487398cb2f8ed9f58563
Autor:
Samantha L Asche-Godin, Adina Israel, Fred C. Ko, Christopher Cardozo, Lauren Harlow, Zachary A. Graham, Marco Brotto, Zhiying Wang, Weihua Huang, Charles V. Mobbs
Publikováno v:
J Gerontol A Biol Sci Med Sci
This study aimed to characterize the effects of laparotomy on post-operative physical function and skeletal muscle gene expression in C57BL/6N mice at 3, 20 and 24 months of age to investigate late-life vulnerability and resiliency to acute surgical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8728f34ddfc0d61d7cbb3fb6d0ac99
https://europepmc.org/articles/PMC9536457/
https://europepmc.org/articles/PMC9536457/
Autor:
Elizabeth K. C. Schwartz, Eitan N. Sosner, Hayley E. Desmond, Stephanie J. Lum, Ji Ying Sze, Charles V. Mobbs
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology
Food produces powerful reinforcement that can lead to overconsumption and likely contributes to the obesity epidemic. The present studies examined molecular mechanisms mediating food-induced reinforcement in the model system C. elegans. After a 1-h t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e59e285607c9a5bf26727ec97f4fdd5
https://www.frontiersin.org/articles/10.3389/fphys.2021.783359/full
https://www.frontiersin.org/articles/10.3389/fphys.2021.783359/full
Autor:
Mary Fowkes, Dominic A Nistal, Melissa Umphlett, Christopher P. Kellner, Panos Roussos, Jonathan Pan, Adam C. Lieber, Jacopo Scaggiante, J D Mocco, Ian T McNeill, Charles V. Mobbs
Publikováno v:
World Neurosurg
Background The safety and efficacy of brain parenchyma biopsy during minimally invasive (MIS) intracerebral hemorrhage (ICH) clot evacuation has not been previously reported. The objective of this study was to establish the safety and diagnostic effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51185b4f9acef1f2696cf3b822cd143
https://doi.org/10.1016/j.wneu.2018.12.058
https://doi.org/10.1016/j.wneu.2018.12.058
Autor:
Charles V. Mobbs, Cesar L. Moreno
Publikováno v:
Molecular and Cellular Endocrinology. 455:33-40
Aging constitutes the central risk factor for major diseases including many forms of cancer, neurodegeneration, and cardiovascular diseases. The aging process is characterized by both global and tissue-specific changes in gene expression across taxon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55e598292629a2d8496e9d9aa870d0b
https://doi.org/10.1016/j.mce.2016.11.013
https://doi.org/10.1016/j.mce.2016.11.013
Autor:
Charles V. Mobbs
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Frontiers in Endocrinology
Frontiers in Endocrinology
During differentiation transient, inducers produce permanent changes in gene expression. A similar phenomenon, transcriptional hysteresis, produced by transient or prolonged exposure to glucose, leads to cumulative, persistent, and largely irreversib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6e032267aa521ab42b7b8a196bf723
https://www.frontiersin.org/article/10.3389/fendo.2018.00232/full
https://www.frontiersin.org/article/10.3389/fendo.2018.00232/full