Streptococcus pneumoniae serotype 15B polysaccharide conjugate elicits a cross-functional immune response against serotype 15C but not 15A

Autor: Li Hao, Michelle M. Kuttel, Neil Ravenscroft, Allison Thompson, A. Krishna Prasad, Seema Gangolli, Charles Tan, David Cooper, Wendy Watson, Paul Liberator, Michael W. Pride, Kathrin U. Jansen, Annaliesa S. Anderson, Ingrid L. Scully

Publikováno v: Vaccine. 40:4872-4880

Protection conferred by pneumococcal polysaccharide conjugate vaccines (PCVs) is associated with PCV-induced antibodies against vaccine-covered serotypes that exhibit functional opsonophagocytic activity (OPA). Structural similarity between capsular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea75730de74e40c77a9de4d3dc08059
https://doi.org/10.1016/j.vaccine.2022.06.041

Survey and Recommendations on the Use of P-Values Driving Decisions in Nonclinical Pharmaceutical Applications

Autor: Stan Altan, Dhammika Amaratunga, Javier Cabrera, Jeonifer Garren, Helena Geys, John Kolassa, David LeBlond, Dingzhou Li, Jason Liao, Jia Liu, Mariusz Lubomirski, Guillermo Miro-Quesada, Steven Novick, Martin Otava, John Peterson, Katharina Reckermann, Tim Schofield, Charles Tan, Kanaka Tatikola, Fetene Tekle, Jennifer Thomas, Kim Vukovinsky

Publikováno v: Statistics in Biopharmaceutical Research. 15:343-358

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee66dd5612364bd87ca6c5791014aa83
https://doi.org/10.1080/19466315.2022.2038258

BNT162b vaccines protect rhesus macaques from SARS-CoV-2

Autor: Bernadette Jesionek, Charles Tan, Christoph Kröner, Jennifer Obregon, Stephanie Hein, Kathleen M. Brasky, Andreas Kuhn, Leyla Fischer, Guy Singh, Diana Schneider, Kathrin U. Jansen, Jane Fontenot, Seungil Han, Michal Gazi, Corinna Rosenbaum, Ingrid L. Scully, Pei Yong Shi, Parag Sahasrabudhe, Stefanie A. Krumm, Hanna Junginger, Camila R. Fontes-Garfias, Julia Schlereth, Bonny Gaby Lui, Mathias Vormehr, Andre P. Heinen, Alptekin Güler, Stephanie Fesser, Sarah C. Dany, Ellene H. Mashalidis, Danka Pavliakova, Shambhunath Choudhary, Mohan S. Maddur, Petra Adams-Quack, Yvonne Feuchter, Matthew C. Griffor, Ferdia Bates, Ramón de la Caridad Güimil Garcia, Tara Ciolino, Özlem Türeci, Stefan Schille, Kena A. Swanson, Kerstin C. Walzer, Alexander Muik, Jakob Loschko, Ayuko Ota-Setlik, Nicole L. Nedoma, Lena M. Kranz, Tompkins Kristin Rachael, Thorsten Klamp, Ugur Sahin, Ann Kathrin Wallisch, Warren Kalina, Olga Gonzalez, Fulvia Vascotto, Philip R. Dormitzer, Ye Che, Kendra J. Alfson, Ricardo Carrion, Thomas Ziegenhals, Shannan Hall-Ursone, Rani S. Sellers, Thomas Hiller, Isis Kanevsky, Matthew R. Gutman, Michael W. Pride, Stephanie Erbar, Bianca Sänger, Deepak Kaushal, Journey Cole, David Eisel, Andreas A.H. Su, Joshua A. Lees, Annette B. Vogel, Arianne Plaschke

Publikováno v: Nature

A safe and effective vaccine against COVID-19 is urgently needed in quantities that are sufficient to immunize large populations. Here we report the preclinical development of two vaccine candidates (BNT162b1 and BNT162b2) that contain nucleoside-mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3903ab0fb32c26fb7ed5bc8fa70296ed
https://doi.org/10.1038/s41586-021-03275-y

Unveiling Grain Growth in Very Dense Galactic Cores

Autor: Roberta Paladini, Alberto Noriega-Crespo, Joao Alves, Boogert, Abraham C., Laurent Cambresy, Sean Carey, Chu, Laurie E., Emmanuel Dartois, Karine Demyk, Draine, Bruce T., Natalia Dzyurkevich, Yasuhiro Hasegawa, Hensley, Brandon S., Klaus Werner Hodapp, Huard, Tracy L., Mika Juvela, Charlene Lefevre, Wanggi Lim, Morris, Patrick W., Laurent Pagani, Yvonne Jean Pendleton, Giulia Perotti, Isabelle Ristorcelli, Jonathan Charles Tan, Neal Turner, Nathalie Ysard

Publikováno v: HAL

Interstellar dust provides the building blocks of planets and the initial grain size distribution in the parent molecular cloud is key to understanding how planets form. Under typical diffuse ISM conditions, dust grains do not grow beyond ~0.5 micron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::104e86dbd8c8b1645ce559aed6c62d7a
https://hal-obspm.ccsd.cnrs.fr/obspm-03601847

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

Autor: Tompkins Kristin Rachael, Kathleen M. Brasky, Kathrin U. Jansen, Ugur Sahin, Camila R. Fontes-Garfias, Hanna Junginger, Lena M. Kranz, Michal Gazi, Kerstin C. Walzer, Joshua A. Lees, Ricardo Carrion, Kendra J. Alfson, Sarah C. Dany, Julia Schlereth, Seungil Han, Parag Sahasrabudhe, Stefanie A. Krumm, Thomas Ziegenhals, Bernadette Jesionek, Bonny Gaby Lui, Stephanie Fesser, Warren Kalina, Corinna Rosenbaum, Oezlem Tuereci, Arianne Plaschke, Petra Adams-Quack, Jennifer Obregon, Guy Singh, Ye Che, Kena A. Swanson, Ingrid L. Scully, Matthew C. Griffor, Diana Schneider, Alptekin Gueler, Pei Yong Shi, Andreas N. Kuhn, Stephanie Hein, Mohan S. Maddur, Mathias Vormehr, Andre P. Heinen, Ellene H. Mashalidis, Annette B. Vogel, Shannan Hall-Ursone, Tara Ciolino, Charles Tan, Isis Kanevsky, Ann-Kathrin Wallisch, Yvonne Feuchter, Thorsten Klamp, David Eisel, Alexander Muik, Jakob Loschko, Christoph Kroener, Bianca Saenger, Philip R. Dormitzer, Danka Pavliakova, Ferdia Bates, Deepak Kaushal, Journey Cole, Michael W. Pride, Stephanie Erbar

To contain the coronavirus disease 2019 (COVID-19) pandemic, a safe and effective vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is urgently needed in quantities sufficient to immunise large populations. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddde412e53da3ab6023b2da69dde6115
https://doi.org/10.1101/2020.09.08.280818