Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Charles T. Gombar"'
Autor:
Darrell R. Abernethy, Balaji Agoram, John M. Allen, Mark E. Arnold, Arthur J. Atkinson, Thomas J. Bateman, Kimberly Bergman, Brian Booth, David W. Boulton, Robert A. Branch, Gilbert J. Burckart, Mary Buschmann, Owen Carmichael, Christine Chamberlain, Ligong Chen, Charles E. Daniels, Promi Das, Jana G. Delfino, John N. Van Den Anker, Albert W. Dreisbach, Michael Dyszel, Justin C. Earp, M. Khair ElZarrad, Osatohanmwen J. Enogieru, Elimika Pfuma Fletcher, David M. Foster, Marilynn C. Frederiksen, Aleksandra Galetin, Pamela D. Garzone, Kathleen M. Giacomini, Megan A. Gibbs, Jack A Gilbert, Danijela Gnjidic, Charles T. Gombar, Denis M. Grant, Charles Grudzinskas, Bengt Hamren, Nicholas H.G. Holford, Shiew-Mei Huang, Renee Iacona, Nina Isoherranen, Denise Jin, Bridgette L. Jones, Gregory L. Kearns, Cindy Kortepeter, Elizabeth Kunkoski, S.W. Johnny Lau, Christopher Leptak, Juan J.L. Lertora, Lawrence J. Lesko, Jiang Liu, Qi Liu, Rajanikanth Madabushi, Raymond Miller, Diane R. Mould, Monica Muñoz, Thomas D. Nolin, Robert Joseph Noveck, R. Scott Obach, Michael Pacanowski, Mary F. Paine, Carl C. Peck, Anuradha Ramamoorthy, A. David Rodrigues, Malcolm Rowland, Chandrahas G. Sahajwalla, Martina Dagmar Sahre, Robert N. Schuck, Khushboo Sharma, Tristan Sissung, Catherine S. Stika, Chris H. Takimoto, Helen Tomkinson, Jack Uetrecht, Paolo Vicini, Karen D. Vo, John A. Wagner, Yaning Wang, Yow-Ming C. Wang, Peter G. Wells, Michael J. Wick, Sook Wah Yee, Ophelia Yin, Nathalie K. Zgheib, Lei Zhang, Hao Zhu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::848d2065918d75dffbea67f6015e7476
https://doi.org/10.1016/b978-0-12-819869-8.09990-0
https://doi.org/10.1016/b978-0-12-819869-8.09990-0
Autor:
Darrell R. Abernethy, Arthur J. Atkinson, William Budris, Ligong Chen, Jerry M. Collins, Charles E. Daniels, Robert L. Dedrick, David A. Flockhart, David M. Foster, Michael Fotis, Marilynn C. Frederiksen, Pamela D. Garzone, Kathleen M. Giacomini, Charles T. Gombar, Charles Grudzinskas, Richard J. Hargreaves, Nicholas H.G. Holford, Shiew-Mei Huang, Bridgette L. Jones, Gregory L. Kearns, Michael Klimas, S.W. Johnny Lau, Juan J.L. Lertora, Lawrence J. Lesko, Elizabeth S. Lowe, Sanford P. Markey, Raymond Miller, Paul F. Morrison, Diane R. Mould, Ameeta Parekh, Carl C. Peck, Scott R. Penzak, Sarah Robertson, Paul Rolan, Malcolm Rowland, Steven W. Ryder, Chandrahas G. Sahajwalla, Edward A. Sausville, Catherine S. Stika, Gregory M. Susla, Chris H. Takimoto, John N. Van Den Anker, Paolo Vicini, Joseph A. Ware, Ethan S. Weiner, Michael J. Wick, Janet Woodcock, Lei Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46a186a2329e7600fe32122ed1ed210b
https://doi.org/10.1016/b978-0-12-385471-1.01002-3
https://doi.org/10.1016/b978-0-12-385471-1.01002-3
Autor:
Charles Grudzinskas, Charles T. Gombar
Drug discovery, evaluation, development, and regulatory review are complex, lengthy, and costly processes that involve in excess of 10,000 interdependent activities. In order to be successful in biopharmaceutical new product development, one needs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c0abe3cd39c17e818c0797853422ecf
https://doi.org/10.1016/b978-0-12-385471-1.00029-5
https://doi.org/10.1016/b978-0-12-385471-1.00029-5
Autor:
Stephen S. Hecht, Neil Trushin, Cheri A. Reid-Quinn, Eric Steven Burak, Steven G. Carmella, Janice L. Southers, Ann B. Jones, Jerry M. Rice, Lucy M. Anderson, Charles T. Gombar
Publikováno v:
Carcinogenesis. 14:229-236
The metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was examined in the patas monkey, in order to provide further information about NNK metabolic pathways in primates. Female patas monkeys were give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbe30816a19a17304f8d2c1e456aaf6
https://doi.org/10.1093/carcin/14.2.229
https://doi.org/10.1093/carcin/14.2.229
Publikováno v:
Cancer letters. 58(1-2)
Despite many years of research on the metabolism of N-nitrosodimethylamine (NDMA) in rats, the significance of enzymatic denitrosation as a pathway remains unclear. To assess the role of this pathway of metabolism in rats, animals were administered N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6552812db652435ae1b79a58c4044b9
https://pubmed.ncbi.nlm.nih.gov/2049775
https://pubmed.ncbi.nlm.nih.gov/2049775
Publikováno v:
Biochemical and Biophysical Research Communications. 90:878-882
A crosslinked dinucleoside, 1,2-(diguanosin-7-yl) ethane, has been isolated from the reaction of guanosine with the antitumor agent, BCNU. The formation of this product suggests that DNA crosslinking, which may be responsible for the cytotoxicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af6638d26b9aba9e5f6aa243e410bbc
https://doi.org/10.1016/0006-291x(79)91909-0
https://doi.org/10.1016/0006-291x(79)91909-0
Publikováno v:
Mutation Research/Genetic Toxicology. 102:145-158
N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) has been reported to induce BHK-21/Cl 13 cell growth in agar suspension. To determine if MNNG was also mutagenic to BHK cells, an ouabain-resistance mutation assay was established using these cells. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46510747c324d077366397bef9412b5
https://doi.org/10.1016/0165-1218(82)90115-x
https://doi.org/10.1016/0165-1218(82)90115-x
Publikováno v:
Biochemical Pharmacology. 29:2639-2643
Calf thymus DNA was reacted with 14 C-labeled bis-chloroethyl nitrosourea (BCNU), and chloroethyl cyclohexyl nitrosourea (CCNU), and the nature of the derivatives investigated in an enzymatic digest. In agreement with earlier studies on polyribonucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b66a987b7b10288ad716c28186b0075
https://doi.org/10.1016/0006-2952(80)90079-9
https://doi.org/10.1016/0006-2952(80)90079-9
Publikováno v:
Carcinogenesis. 2(7)
The capacity of eukaryotic cells to modulate the activities of DNA repair enzymes during cell proliferation was examined. Using regenerating rat liver as a model system, the specific activities of the DNA repair enzymes uracil DNA glycosylase and 3-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fc0c86c551f9dd2a3e5a76b4106045
https://pubmed.ncbi.nlm.nih.gov/7273338
https://pubmed.ncbi.nlm.nih.gov/7273338