Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Charles T. Foster"'
Publikováno v:
Genesdevelopment. 31(23-24)
Both the MRTF–SRF and the YAP–TEAD transcriptional regulatory networks respond to extracellular signals and mechanical stimuli. We show that the MRTF–SRF pathway is activated in cancer-associated fibroblasts (CAFs). The MRTFs are required in ad
Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export
Autor:
Erik Sahai, Charles T. Foster, Ming Jiang, Michael Howell, Robert P. Jenkins, Anna M Dowbaj, Nil Ege, Steven Hooper
Publikováno v:
Cell Systems
Summary The transcriptional regulator YAP1 is critical for the pathological activation of fibroblasts. In normal fibroblasts, YAP1 is located in the cytoplasm, while in activated cancer-associated fibroblasts, it is nuclear and promotes the expressio
Autor:
Sally A. Edwards, Nathalie Conte, Allan Bradley, Charles T. Foster, Rajinder Singh, Shaun M. Cowley, Oliver M. Dovey, George S. Vassiliou, Jennifer M. Edwards
Publikováno v:
Blood. 121:1335-1344
Histone deacetylase 1 and 2 (HDAC1/2) regulate chromatin structure as the catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes. To better understand the key pathways regulated by HDAC1/2 in the adaptive immune system and inform their e
Autor:
Charles T. Foster, Warren A. Whyte, Richard A. Young, David A. Orlando, Garrett M. Frampton, Steve Bilodeau, Heather A. Hoke, Shaun M. Cowley
Publikováno v:
Nature. 562:E24-E24
In this Letter, the western blot for LSD1 in the right panel of Fig. 2b ('TCP +') was inadvertently duplicated from the tubulin blot immediately below. The actual tubulin western blot shows the same result, with no significant change to the levels of
Autor:
Garrett M. Frampton, Shaun M. Cowley, Richard A. Young, Steve Bilodeau, Charles T. Foster, Warren A. Whyte, Heather A. Hoke, David A. Orlando
In embryonic stem cells, the histone demethylase LSD1 occupies the enhancers of active genes and, together with the NuRD complex, decommissions the enhancers during differentiation. Gene activation in the developing embryo occurs when transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b09254dafd2a40bca4c1e953b90170
https://europepmc.org/articles/PMC4144424/
https://europepmc.org/articles/PMC4144424/
Autor:
Nick Barlev, Jin Li Luo, Oliver M. Dovey, Charles T. Foster, Allan Bradley, Larissa Lezina, Shaun M. Cowley, Timothy W. Gant
Lysine-specific demethylase 1 (LSD1), which demethylates mono- and dimethylated histone H3-Lys4 as part of a complex including CoREST and histone deacetylases (HDACs), is essential for embryonic development in the mouse beyond embryonic day 6.5 (e6.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd4bde7f9dfaa663c82d820fb7956da
https://europepmc.org/articles/PMC2950538/
https://europepmc.org/articles/PMC2950538/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(18)
Histone deacetylases (HDAC) 1 and 2 are highly similar enzymes that help regulate chromatin structure as the core catalytic components of corepressor complexes. Although tissue-specific deletion of HDAC1 and HDAC2 has demonstrated functional redundan
Autor:
Victoria S. S. Aldridge, Catrin Pritchard, Tamihiro Kamata, Catherine Andreadi, Hong Jin, Susan Giblett, Charles T. Foster, Linda A. S. Carragher
Publikováno v:
Biochemical Society transactions. 35(Pt 5)
Oncogenic mutations in the BRAF gene are detected in ∼7% of human cancer samples with a particularly high frequency of mutation in malignant melanomas. Over 40 different missense BRAF mutations have been found, but the vast majority (>90%) represen
Publikováno v:
Cell Cycle. 9:2700-2701