Výsledky vyhledávání - "Charles T H Chuah"

Akademický článek

The HDAC inhibitor SB939 overcomes resistance to BCR-ABL kinase Inhibitors conferred by the BIM deletion polymorphism in chronic myeloid leukemia.

Autor: Muhammad Rauzan, Charles T H Chuah, Tun Kiat Ko, S Tiong Ong

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174107 (2017)

Chronic myeloid leukemia (CML) treatment has been improved by tyrosine kinase inhibitors (TKIs) such as imatinib mesylate (IM) but various factors can cause TKI resistance in patients with CML. One factor which contributes to TKI resistance is a germ

Externí odkaz: https://doaj.org/article/333aea2122484f3baab98c46f3c10f53

Zobrazit plný text záznamu

Bone Marrow Cytogenetics Workup: Application of Lean Management System to Determine if Additional Cell Workup is Helpful and Necessary to Analysis

Autor: Alvin S T, Lim, Ting Jie, Chen, Tse Hui, Lim, Mary, Tan, Lai Ching, Lau, Ping, Lim, Geok Yee, Lee, Li Eng, Loo, Fiona P S, Liaw, Charles T H, Chuah, Yeow Tee, Goh, Sim Leng, Tien

Publikováno v: Annals of the Academy of Medicine, Singapore. 39:696-704

Introduction: High workload volumes in a Cytogenetics laboratory can lead to long result turn-around times (TAT). This study aimed to improve laboratory efficiency by adopting Lean Management System initiatives to increase productivity through the el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f27008222da6fdf6d6a9783b1dd390
https://doi.org/10.47102/annals-acadmedsg.v39n9p696

Zobrazit plný text záznamu

Detection and quantification of the abelson tyrosine kinase domains of the BCR-ABL gene translocation in chronic myeloid leukaemia using genomic quantitative real-time polymerase chain reaction

Autor: Charles A, Gullo, Charles T H, Chuah, William Y K, Hwang, Gerrard K H, Teoh

Publikováno v: Annals of the Academy of Medicine, Singapore. 35(10)

Since undetectable BCR-ABL mRNA transcription does not always indicate eradication of the Ph+ CML clone and since transcriptionally silent Ph+ CML cells exist, quantitation by genomic PCR of bcr-abl genes can be clinically useful. Furthermore, hotspo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecc47c282121b0c9a85938feb763ad73
https://pubmed.ncbi.nlm.nih.gov/17102890

Zobrazit plný text záznamu

Akademický článek

A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

Autor: Becky Pinjou Tsai, Judith Jimenez, Sharon Lim, Kerry D. Fitzgerald, Min Zhang, Charles T. H. Chuah, Haley Axelrod, Luke Nelson, S. Tiong Ong, Bert L. Semler, Marian L. Waterman

Publikováno v: Open Biology, Vol 4, Iss 11 (2014)

Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined. Lymphoid enhancer factor-1 (LEF-1), a Wnt-mediating transcription fac

Externí odkaz: https://doaj.org/article/d5d954df2e634b6e95a8558ff0db7719

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání