Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Charles T Esmon"'
Autor:
Joy Ogbechi, Marie-Thérèse Ruf, Belinda S Hall, Katherine Bodman-Smith, Moritz Vogel, Hua-Lin Wu, Alexander Stainer, Charles T Esmon, Josefin Ahnström, Gerd Pluschke, Rachel E Simmonds
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005011 (2015)
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of
Externí odkaz:
https://doaj.org/article/20d05ae500fa40eaa366b696a73a51ca
Autor:
Julian I Borissoff, Jeroen J T Otten, Sylvia Heeneman, Peter Leenders, René van Oerle, Oliver Soehnlein, Sarah T B G Loubele, Karly Hamulyák, Tilman M Hackeng, Mat J A P Daemen, Jay L Degen, Hartmut Weiler, Charles T Esmon, Joanne van Ryn, Erik A L Biessen, Henri M H Spronk, Hugo ten Cate
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55784 (2013)
BACKGROUND: Variations in the blood coagulation activity, determined genetically or by medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects of coagulation proteases. Published experimental studies have yielded
Externí odkaz:
https://doaj.org/article/0d40d4d7178745408a7059d1141ca157
Autor:
Liesbeth M Kager, Marcel Schouten, W Joost Wiersinga, J Daan de Boer, Lionel C W Lattenist, Joris J T H Roelofs, Joost C M Meijers, Marcel Levi, Arjen M Dondorp, Charles T Esmon, Cornelis van 't Veer, Tom van der Poll
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 7, p e2306 (2013)
The endothelial protein C receptor (EPCR) enhances anticoagulation by accelerating activation of protein C to activated protein C (APC) and mediates anti-inflammatory effects by facilitating APC-mediated signaling via protease activated receptor-1. W
Externí odkaz:
https://doaj.org/article/1bd7c006b8d94f8e931d0bff87d617ae
Autor:
Florence Schaffner, Naho Yokota, Tatiana Carneiro-Lobo, Maki Kitano, Michael Schaffer, G Mark Anderson, Barbara M Mueller, Charles T Esmon, Wolfram Ruf
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61071 (2013)
Several markers identify cancer stem cell-like populations, but little is known about the functional roles of stem cell surface receptors in tumor progression. Here, we show that the endothelial protein C receptor (EPCR), a stem cell marker in hemato
Externí odkaz:
https://doaj.org/article/da8ef9bf849d4e15a8b22dd9631721d9
Autor:
Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80110 (2013)
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (A
Externí odkaz:
https://doaj.org/article/5b46ccfab9ca479b9559e7eb89df9a94
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59304 (2013)
Recent studies have established that factor VIIa (FVIIa) binds to the endothelial cell protein C receptor (EPCR). FVIIa binding to EPCR may promote the endocytosis of this receptor/ligand complex. Rab GTPases are known to play a crucial role in the e
Externí odkaz:
https://doaj.org/article/603dc7fe8f7d4d809d17243daea1721c
Autor:
Mryanda J Sopel, Nicole L Rosin, Alec G Falkenham, Michael Bezuhly, Charles T Esmon, Timothy D G Lee, Robert S Liwski, Jean-Francois Légaré
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45663 (2012)
Myocardial fibrosis contributes to the development of heart failure. Activated Protein C (aPC) is a circulating anticoagulant with anti-inflammatory and cytoprotective properties. Using a model of myocardial fibrosis second to Angiotensin II (AngII)
Externí odkaz:
https://doaj.org/article/80087e82555c4284b9140d52aae8f3d9
Autor:
Colin F. Greineder, Ian H. Johnston, Carlos H. Villa, Kandace Gollomp, Charles T. Esmon, Douglas B. Cines, Mortimer Poncz, Vladimir R. Muzykantov
Publikováno v:
Blood Advances, Vol 1, Iss 18, Pp 1452-1465 (2017)
Abstract: Diverse human illnesses are characterized by loss or inactivation of endothelial thrombomodulin (TM), predisposing to microvascular inflammation, activation of coagulation, and tissue ischemia. Single-chain antibody fragment (scFv)/TM) fusi
Externí odkaz:
https://doaj.org/article/5eaf34428b9e4bf6807c10cf61c2e8ce
Autor:
Shiva Keshava, Jagan Sundaram, Anuradha Rajulapati, Charles T. Esmon, Usha R. Pendurthi, L. Vijaya Mohan Rao
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1206-1214 (2017)
Abstract: Recent studies established that clotting factor VIIa (FVIIa) binds endothelial cell protein C receptor (EPCR). It has been speculated that FVIIa interaction with EPCR might augment the hemostatic effect of recombinant FVIIa (rFVIIa) in ther
Externí odkaz:
https://doaj.org/article/414c43275e3f4e399e2a807b14913bcc
Autor:
Miao Jiang, Fei Yang, Yizhi Jiang, Lu Cheng, Jingjing Han, Jiawei Yi, Guige Zhang, Zhenni Ma, Lijuan Cao, Bin Zuo, Lixia Zhou, Lulu Huang, Siying Niu, Zhisong Xia, Xuefeng Zhou, Xia Bai, Naomi L. Esmon, Changgeng Ruan, Lijun Xia, Yue Han, Charles T. Esmon, Depei Wu, Jun Xu
Publikováno v:
Blood Advances. 6:3304-3314
Hemophilia A and B are hereditary coagulation defects resulting in unstable blood clotting and recurrent bleeding. Current factor replacement therapies have major limitations such as the short half-life of the factors and development of inhibitors. A