Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Charles S. Shanahan"'
Autor:
Charles S. Shanahan, Appasaheb L. Kadam, Barreddi Chiranjeevi, Aline A. Nunes, Aravindan Jayaraman, Saeed Ahmad, Sarah L. Aleshire, Kai O. Donsbach, B. Frank Gupton, Michel C. Nuckols
Nirmatrelvir, the novel antiviral component of Pfizer’s orally available combination therapy Paxlovid, used to treat COVID-19, presents a significant synthetic challenge. Herein, we report process optimization insights that could enable a scalable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2a3122a9a6b3664e212d2ce214e878a
https://doi.org/10.26434/chemrxiv-2022-cn0k1
https://doi.org/10.26434/chemrxiv-2022-cn0k1
Publikováno v:
SAE International Journal of Fuels and Lubricants. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9a30de5b1c97a73feae60240150d831
https://doi.org/10.4271/2017-01-2298
https://doi.org/10.4271/2017-01-2298
Publikováno v:
Tetrahedron. 69:7592-7607
A formal synthesis of didehydrostemofoline and isodidehydrostemofoline has been accomplished by preparing an intermediate in the Overman synthesis of these alkaloids from commercially available 2-deoxy- d -ribose. The work presented in this account c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb712eaa079c005d383a4703dccb278d
https://doi.org/10.1016/j.tet.2013.03.104
https://doi.org/10.1016/j.tet.2013.03.104
Publikováno v:
European Journal of Organic Chemistry. 2013:6032-6037
A Lewis acid mediated coupling reaction of enol-diazo nucleophiles and propargyl acetates has provided rapid and diverse access to complex alkynyl-tethered diazocarbonyl compounds. The ability of the coupling reaction to vary critical functionality f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67c2823615c9faa3fd741687092a4fa0
https://doi.org/10.1002/ejoc.201301000
https://doi.org/10.1002/ejoc.201301000
Publikováno v:
Angewandte Chemie International Edition. 51:10596-10599
Sweet to the Core Enantioselective formal total syntheses of the Stemona alkaloids didehydrostemofoline and isodidehydrostemofoline were accomplished in 24 steps from commercially available 2-deoxy-d-ribose. The synthesis features a novel cascade of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e84f32303a24e0e80aabcd9325bb221
https://doi.org/10.1002/anie.201205274
https://doi.org/10.1002/anie.201205274
Publikováno v:
Organic Letters. 14:3608-3611
The intramolecular acid catalyzed aldol cyclization of 2,3,7-triketoesters formed from ζ-keto-α-diazo-β-ketoesters provides highly functionalized cyclopentanones with good diastereoselectivity in high overall yields via kinetically controlled and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b47acc3472f61eb8b2e92dbd56c2d3
https://doi.org/10.1021/ol301317a
https://doi.org/10.1021/ol301317a
Publikováno v:
New J. Chem.. 36:492-505
Linear analogs have been synthesized to model disassembling dendrimers. These linear analogs provide a facile synthesis to molecules that can be used to test new trigger groups and cleavage vectors. Vanillin and o-vanillin were used as the monomer un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f71d00c22ed098145f8dd8c5c5b4016
https://doi.org/10.1039/c1nj20841a
https://doi.org/10.1039/c1nj20841a
Publikováno v:
Tetrahedron Letters. 52:4076-4079
Novel, intramolecular 1,3-dipolar cycloadditions of azomethine ylides have been applied to the synthesis of functionalized core structures of the stemofoline alkaloids. In an effort to maximize the efficiency of this key transformation in the context
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffeaa08ce22c444bb91475b68bf91bc
https://doi.org/10.1016/j.tetlet.2011.05.121
https://doi.org/10.1016/j.tetlet.2011.05.121
Publikováno v:
Organic Letters. 12:4944-4947
The convergent synthesis of geometrically degradable dendrimers based on the 2,4-bis(hydroxymethyl)phenol subunit is presented. The key step of the synthetic scheme involves the CuI/3,4,7,8-tetramethyl-1,10-phenanthroline-catalyzed coupling of aryl i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec25a5ad3ec7fe77166ab06a402db341
https://doi.org/10.1021/ol102081q
https://doi.org/10.1021/ol102081q
Publikováno v:
ChemInform. 46
Recent studies of diastereoselective conjugate additions of monoorganocuprates, Li[RCuI], to chiral γ-alkoxycrotonates and fumarates are disclosed. This methodology was applied to the shortest total synthesis of (-)-dihydroprotolichesterinic acid to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0696e3004f26e2c6571d502adb6ecee
https://doi.org/10.1002/chin.201552016
https://doi.org/10.1002/chin.201552016