Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Charles S. Owen"'
Publikováno v:
Endothelium. 9:205-216
Angiostatin inhibits angiogenesis by binding to endothelial cells (ECs) lining the vasculature of growing tumors. These cells are in a dynamic state during angiogenesis and are thus not firmly attached to the extracellular matrix. This makes them mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6899171098d4f5958ca4a3d16c5b55b5
https://doi.org/10.1080/10623320213633
https://doi.org/10.1080/10623320213633
Publikováno v:
Journal of Cellular Physiology. 183:373-380
Tumor cells in vivo often exist in an ischemic microenvironment that would compromise the growth of normal cells. To minimize intracellular acidification under these conditions, these cells are thought to upregulate H+ transport mechanisms and/or slo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d054e87ccb64b476c58c108d6edadac
https://doi.org/10.1002/(sici)1097-4652(200006)183:3<373::aid-jcp10>3.0.co
https://doi.org/10.1002/(sici)1097-4652(200006)183:3<373::aid-jcp10>3.0.co
Publikováno v:
International Journal of Hyperthermia. 14:227-232
Cells which have been adapted to growth at low extracellular pH (pHe) typically develop both an upregulation of steady state intracellular pH (pHi) and an ability to develop thermotolerance to 42 degrees C hyperthermia. These properties were acquired
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165400f13ad9fdb0f4f72f25558de4fa
https://doi.org/10.3109/02656739809018227
https://doi.org/10.3109/02656739809018227
Publikováno v:
Journal of Cellular Physiology. 173:397-405
Intracellular pH (pHi) homeostasis is crucial to cell survival. Cells that are chronically exposed to a low pH environment must adapt their hydrogen ion extrusion mechanisms to maintain their pHi in the physiologic range. An important component of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba3f83c16d14891fb6c6a41b4c0befd
https://doi.org/10.1002/(sici)1097-4652(199712)173:3<397::aid-jcp12>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199712)173:3<397::aid-jcp12>3.0.co
Autor:
Allan M. Lefer, Patricia M. Pooler, Sean V. Ryan, Carsten Skurk, Scott A. Waldman, Charles Nuss, S. L. Carrithers, Charles S. Owen, Scott J. Parkinson
Publikováno v:
The Journal of Clinical Pharmacology. 36:365-373
Amifostine, a chemo- and radioprotective agent developed as adjunctive therapy for malignancies, induces hypotension after approximately 20% of patient administrations. This study examines the molecular mechanisms underlying hypotension induced by am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddabb34a0ca0007cd4ca4b64c10d762
https://doi.org/10.1002/j.1552-4604.1996.tb04214.x
https://doi.org/10.1002/j.1552-4604.1996.tb04214.x
Publikováno v:
Journal of Cellular Physiology. 166:438-445
As an in vitro model for the low extracellular pH (pHe) which has frequently been observed in tumors, cell lines have been grown in a low-pH medium in order to allow cell adaptation to that milieu. Two Chinese hamster cell lines [Chinese hamster ovar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd8492bd73b639a350d57a0a3281df57
https://doi.org/10.1002/(sici)1097-4652(199602)166:2<438::aid-jcp22>3.0.co
https://doi.org/10.1002/(sici)1097-4652(199602)166:2<438::aid-jcp22>3.0.co
Autor:
Miriam L. Wahl, Matthew Russell, Dennis B. Leeper, Suzanne B. Bobyock, Wendy A. Woodward, Charles S. Owen, Heather D. Perry
Publikováno v:
Journal of Fluorescence. 5:329-335
Fluorescent measurements of intracellular H(+) and Na(+) are improved by using whole spectra of the fluorescent indicators BCECF and SBFI, respectively. The extra data in whole spectra enable both an accurate calibration and a ready detection of arti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06069ecf5949a806eecafe86595e67a
https://doi.org/10.1007/bf01152559
https://doi.org/10.1007/bf01152559
Autor:
Randy L. Shuler, Charles S. Owen
Publikováno v:
Immunology and Cell Biology. 71:1-11
Peroxidase-conjugated anti-surface immunoglobulin (sIg) was used quantitatively to monitor endocytosis of crosslinked sIg on murine B lymphocytes. The role of biochemical second messengers in the initiation of endocytosis was assessed by employing se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff13e081a6616d8aa835e37e7a787a5c
https://doi.org/10.1038/icb.1993.1
https://doi.org/10.1038/icb.1993.1
Publikováno v:
Biochemistry. 31:6538-6544
The influence of the protein matrix on the reactivity of external molecules with a species buried within the protein interior is considered in two general ways: (1) there may be structural fluctuations that allow for the diffusive penetration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74d9992f73d36e18dbd245f648631e26
https://doi.org/10.1021/bi00143a025
https://doi.org/10.1021/bi00143a025
Publikováno v:
Journal of Fluorescence. 2:75-80
Carboxy-SNARF-1 is an emission-changing, pH-sensitive probe for measurements of intracellular pH. However, the protonated and deprotonated forms of the dye interact differently with intracellular constituents, and this imposes new requirements on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c64c8dae1c61b2b24a9822f80516e7
https://doi.org/10.1007/bf00867666
https://doi.org/10.1007/bf00867666