Zobrazeno 1 - 10
of 434
pro vyhledávání: '"Charles S. Cox"'
Autor:
Christopher T. Bolden, Max A. Skibber, Scott D. Olson, Miriam Zamorano Rojas, Samantha Milewicz, Brijesh S. Gill, Charles S. Cox
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract The Blood–Brain Barrier (BBB) is a highly-selective physiologic barrier responsible for maintaining cerebral homeostasis. Innovative in vitro models of the BBB are needed to provide useful insights into BBB function with CNS disorders like
Externí odkaz:
https://doaj.org/article/191ae9792cb245d0a86abb3a0373fb19
Autor:
Supinder S. Bedi, Michael C. Scott, Max A. Skibber, Akshita Kumar, Henry W. Caplan, Hasen Xue, David Sequeira, Alison L. Speer, Fanni Cardenas, Franciska Gudenkauf, Karen Uray, Amit K. Srivastava, Alan R. Prossin, Charles S. Cox
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Traumatic brain injury (TBI) results in activated microglia. Activated microglia can be measured in vivo by using positron emission topography (PET) ligand peripheral benzodiazepine receptor standardized uptake values (PBR28suv). Cell based
Externí odkaz:
https://doaj.org/article/3f8dcf5c326345358095521f0c347884
Autor:
Joseph D. Krocker, Madeline E. Cotton, Jacob B. Schriner, Baron K. Osborn, Michael M. Talanker, Yao-Wei W. Wang, Charles S. Cox, Charles E. Wade
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The TRPM4 gene codes for a membrane ion channel subunit related to inflammation in the central nervous system. Recent investigation has identified an association between TRPM4 single nucleotide polymorphisms (SNPs) rs8104571 and rs150391806
Externí odkaz:
https://doaj.org/article/d350293ca1d4451a890a0d90031f6b45
Autor:
Jacob B. Schriner, MD, J. Michael Van Gent, DO, M. Adam Meledeo, PhD, Scott D. Olson, PhD, Bryan A. Cotton, MD, Charles S. Cox, Jr, MD, Brijesh S. Gill, MD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 6, p e0925 (2023)
OBJECTIVES:. This narrative review article seeks to highlight the effects of citrate on physiology during massive transfusion of the bleeding patient. DATA SOURCES:. A limited library of curated articles was created using search terms including “ci
Externí odkaz:
https://doaj.org/article/4c64afc797774a33815f693d2342280d
Autor:
Assaf Gottlieb, Naama Toledano-Furman, Karthik S. Prabhakara, Akshita Kumar, Henry W. Caplan, Supinder Bedi, Charles S. Cox, Scott D. Olson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Traumatic brain injury (TBI) results in a cascade of cellular responses, which produce neuroinflammation, partly due to the activation of microglia. Accurate identification of microglial populations is key to understanding therapeutic approa
Externí odkaz:
https://doaj.org/article/23b474813678411bab4e7276522ecb56
Autor:
Muhammad E. Haque, Khader M. Hasan, Sarah George, Clark Sitton, Seth Boren, Octavio D. Arevalo, Farhaan Vahidy, Xu Zhang, Charles S. Cox Jr., Susan Alderman, Jaroslaw Aronowski, James C. Grotta, Sean I. Savitz
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 7, Pp 943-955 (2021)
Abstract Bone marrow mononuclear cells (MNCs) attenuate secondary degeneration and enhance recovery in stroke animal models. In a nonrandomized clinical trial, we imaged 37 patients with stroke: 17 patients treated with MNCs (treated) and 20 patients
Externí odkaz:
https://doaj.org/article/807999f2182f4fc8b1a5a5e06fce595a
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mesenchymal stromal cells (MSC) undergo functional maturation upon their migration from bone marrow and introduction to a site of injury. This inflammatory licensing leads to heightened immune regulation via cell-to-cell interaction and the secretion
Externí odkaz:
https://doaj.org/article/edf0cec9d5a84effadfce7f3b0d9adc6
Autor:
Miguel F. Diaz, Pau lina D. Horton, Sandeep P. Dumbali, Akshita Kumar, Megan Livingston, Max A. Skibber, Amina Mohammadalipour, Brijesh S. Gill, Songlin Zhang, Charles S. Cox, Pamela L. Wenzel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-19 (2020)
Abstract The only available option to treat radiation-induced hematopoietic syndrome is allogeneic hematopoietic cell transplantation, a therapy unavailable to many patients undergoing treatment for malignancy, which would also be infeasible in a rad
Externí odkaz:
https://doaj.org/article/fe396376d80247989e626bcbba03e9ec
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionTraumatic brain injury is a leading cause of injury-related death and morbidity. Multiple clinical and pre-clinical studies have reported various results regarding sex-based differences in TBI. Our accepted rodent model of traumatic brain
Externí odkaz:
https://doaj.org/article/c981cd6032aa483b973d747c22fd5320
Autor:
Henry W. Caplan, Karthik S. Prabhakara, Akshita Kumar, Naama E. Toledano‐Furman, Cecilia Martin, Louis Carrillo, Nicolas F. Moreno, Andrea S. Bordt, Scott D. Olson, Charles S. Cox Jr.
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 903-916 (2020)
Abstract Traumatic brain injury (TBI) causes a profound inflammatory response within the central nervous system and peripheral immune system, which contributes to secondary brain injury and further morbidity and mortality. Preclinical investigations
Externí odkaz:
https://doaj.org/article/3fa4d019f5a44c03b2b2b10829ba1d44