Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Charles S. Chung"'
Strain rate of stretch affects crossbridge detachment during relaxation of intact cardiac trabeculae
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/dfe6db154a3b4c26b5f97ca0d3da5fbf
Publikováno v:
Physiological Reports, Vol 11, Iss 21, Pp n/a-n/a (2023)
Abstract Dysregulation of collagen deposition, degradation, and crosslinking in the heart occur in response to increased physiological stress. Collagen content has been associated with ultrasonic backscatter (brightness), and we have shown that the a
Externí odkaz:
https://doaj.org/article/5f4067a7a27046d5aeb3e6b1a1231f70
Autor:
Robbert J. van der Pijl, Brian Hudson, Tomotaroh Granzier-Nakajima, Frank Li, Anne M. Knottnerus, John Smith, Charles S. Chung, Michael Gotthardt, Henk L. Granzier, Coen A. C. Ottenheijm
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK r
Externí odkaz:
https://doaj.org/article/4c2a2f1c6d3b4955852a71d1f669caee
Autor:
Lizhuo Ai, Edith Perez, AnnaDorothea Asimes, Theerachat Kampaengsri, Maxime Heroux, Andrei Zlobin, Mark A. Hiske, Charles S. Chung, Toni R. Pak, Jonathan A. Kirk
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 9 (2020)
Background Approximately 1 in 6 adolescents report regular binge alcohol consumption, and we hypothesize it affects heart growth during this period. Methods and Results Adolescent, genetically diverse, male Wistar rats were gavaged with water or etha
Externí odkaz:
https://doaj.org/article/e4662dd2c352410c89f7b887d8126edb
Publikováno v:
Physiological Reports, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract Intact cardiomyocytes are used to investigate cardiac contractility and evaluate the efficacy of new therapeutic compounds. Primary enzymatic isolation of adult rodent cardiomyocytes has limitations, including low cardiomyocyte survival, whi
Externí odkaz:
https://doaj.org/article/a6c691a7446f4c3eac59cf2f7c888224
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training. Exercise training increases cardiac compliance in humans, but the mechanisms u
Externí odkaz:
https://doaj.org/article/8cf8bb5db8844cabb61ae5f9555ae75e
Autor:
Dhanushka N. P. Munkanatta Godage, Garrett C. VanHecke, Kusal T. G. Samarasinghe, Han-Zhong Feng, Mark Hiske, Joshua Holcomb, Zhe Yang, Jian-Ping Jin, Charles S. Chung, Young-Hoon Ahn
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Ischemic reperfusion or nutrient deprivation that produces reactive oxygen species can lead to a loss of muscle contractile function. Here the authors show that glutathionylation of the lysine methyltransferase SMYD2 contributes to degradation or dis
Externí odkaz:
https://doaj.org/article/e380dd272fcc4d37b01928dfbce9321f
Publikováno v:
Nutrients, Vol 13, Iss 9, p 3129 (2021)
Fructose and salt intake remain high, particularly in adolescents and young adults. The present studies were designed to evaluate the impact of high fructose and/or salt during pre- and early adolescence on salt sensitivity, blood pressure, arterial
Externí odkaz:
https://doaj.org/article/aadc016946d74bbbb8257ceb1a93cf88
Autor:
Bo Pan, Shuo Yuan, Linda Mayernik, Yi Tian Yap, Kamiar Moin, Charles S. Chung, Krishnarao Maddipati, Stephen A. Krawetz, Zhibing Zhang, Rex A. Hess, Xuequn Chen
Publikováno v:
FASEB J
Peroxisomal fatty acyl-CoA reductase 1 (FAR1) is a rate-limiting enzyme for ether lipid (EL) synthesis. Gene mutations in FAR1 cause a rare human disease. Furthermore, altered EL homeostasis has also been associated with various prevalent human disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd91b8d029e6363edd9da08a0f3abfb
https://europepmc.org/articles/PMC10150578/
https://europepmc.org/articles/PMC10150578/
Publikováno v:
Journal of Visualized Experiments.