Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Charles S. Agree"'
Autor:
Jennifer Lafontaine, Ping Chen, Quyen-Quyen T. Do, Karen Siegel, Lilian Y. Li, Paul S. Humphries, David M. Wilhite, Tianlun Wang, Charles S. Agree, David Alexander, Sergei Timofeevski, Ranjan Jagath Rajapakse, Elizabeth A. Lunney
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(8)
The development of a series of novel 4-substituted-2-aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, and the in vitro inhibitory value for a c-Jun cellular assay are discuss
Autor:
James Arthur Thomson, Richard E. Showalter, J. Ernest Villafranca, Anna Tempczyk-Russell, Melwyn A. Abreo, Laura A. Pelletier, Charles R. Kissinger, Bin Li, Jerry J. Meng, Stephen Margosiak, Charles S. Agree, Robert M. Aust, Darin Vanderpool, Paul A. Rejto
Publikováno v:
Journal of molecular biology. 342(3)
The enzyme 17beta-hydroxysteroid dehydrogenase type 10 (HSD10), also known as amyloid beta-peptide-binding alcohol dehydrogenase (ABAD), has been implicated in the development of Alzheimer's disease. This protein, a member of the short-chain dehydrog