Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Charles S Hottenstein"'
1
Structure and Functional Characterization of a Humanized Anti-CCL20 Antibody following Exposure to Serum Reveals the Formation of Immune Complex That Leads to Toxicity
Autor: Stephen H. Trulli, J. David Taylor, Shugui Chen, Michael Herdman, Charles S Hottenstein, Michael Byrne, Joseph Minetti, John R. White, Andrew S. Thomson, Gerben Bouma, Shing H. Mai
Publikováno v: The Journal of Immunology. 206:1067-1076
mAbs have revolutionized the treatment of autoimmune disorders. Even though mAbs have shown impressive efficacy in blocking T cell or B cell activation and/or recruitment to sites of inflammation, this group of biologicals are not devoid of adverse e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961e7012799751a7d4ba2951ec4699f6
https://doi.org/10.4049/jimmunol.2000336
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3
2018 White Paper on Recent Issues in Bioanalysis: ‘A global bioanalytical community perspective on last decade of incurred samples reanalysis (ISR)’ (Part 1 – small molecule regulated bioanalysis, small molecule biomarkers, peptides & oligonucleotide bioanalysis)
Autor: Charles S Hottenstein, Seongeun Julia Cho, Dina Goykhman, Daniela Verthelyi, Jens Sydor, Natasha Savoie, Steven P. Piccoli, Stephanie Fraser, Alex Bulychev, Elana Cherry, Yan Zhang, Anna Edmison, Ingo Röhl, Daniela Fraier, Lieve Dillen, Fabio Garofolo, Yoshiro Saito, Michael H. Buonarati, Adrien Musuku, Timothy Sangster, Barry R Jones, Eric Yang, Ragu Ramanathan, Tate Owen, Nico C van de Merbel, Anton I. Rosenbaum, Christopher Stebbins, Allena J. Ji, Daniel A. Norris, Akiko Ishii-Watabe, Rachel Green, Sean Kassim, Emma Whale, Amanda Wilson, Lina Luo, Neil Henderson, Christopher A. James, Sam Haidar, Alexander Behling, Nicola Hughes, Yuanxin Xu, Scott G. Summerfield, Isabelle Cludts, Stephen Vinter, Tom Verhaeghe, Gustavo Mendes Lima Santos, Robert Dodge, Eric Woolf, Mark Ma, Jan Welink, Kirk Brown, Uma Kavita, Hyun Gyung Jang
Publikováno v: Bioanalysis. 10:1781-1801
The 2018 12th Workshop on Recent Issues in Bioanalysis (12th WRIB) took place in Philadelphia, PA, USA on April 9–13, 2018 with an attendance of over 900 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8d073b6bbc20524afacbc35eb80548f
https://doi.org/10.4155/bio-2018-0268
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4
2016 White Paper on recent issues in bioanalysis: focus on biomarker assay validation (BAV): (Part 3 – LBA, biomarkers and immunogenicity)
Autor: Akiko Ishii-Watabe, Albert Torri, Rong Zeng, Daniel Kramer, Steven P. Piccoli, David J. Uhlinger, Stephanie Fraser, Patricia Siguenza, Afshin Safavi, John Smeraglia, Apollon Papadimitriou, Yan G. Ni, Susan M. Richards, Kyra J. Cowan, Alessandra Vitaliti, Lakshmi Amaravadi, Boris Gorovits, Gustavo Mendes Lima Santos, John Kadavil, Sam Haidar, Jan Welink, Yongchang Qiu, João Pedras-Vasconcelos, Chan C. Whiting, Li Xue, Christina Satterwhite, John Kamerud, Swati Gupta, Natasha Savoie, Herbert Birnboeck, Yoshiro Saito, Paul Rhyne, Fabrizio Galliccia, Laurent Cocea, Stephanie Croft, Bonnie Wu, Theingi M. Thway, Virginia Litwin, Corinna Krinos-Fiorotti, Darshana Jani, Charles S Hottenstein, Vinita Gupta, Roland F Staack, Fabio Garofolo, Eginhard Schick, Kara Scheibner, Meena Subramanyam, John Allinson, Renuka Pillutla, Robert Nelson, Flora Berisha, Martin Ullmann, Giane Sumner
Publikováno v: Bioanalysis. 8:2475-2496
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place in Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract research organizatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a67282718390ee4d7f9eb9599bdcf67
https://doi.org/10.4155/bio-2016-4989
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5
Bioanalytical challenges and unique considerations to support pharmacokinetic characterization of bispecific biotherapeutics
Autor: Charles S Hottenstein, Dominic Warrino, Mark Ma, Xiaohui Xu, Kelly Colletti, Sheldon Leung, Eric Wakshull, Tong-Yuan Yang, Susan Pederson
Publikováno v: Bioanalysis. 11(5)
Compared with conventional (monospecific) therapeutics, bispecific protein therapeutics present unique challenges for pharmacokinetic (PK) characterization – namely, the characterization of multiple functional domains as well as the consideration o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17189e977939cc0006cf4e375e477939
https://pubmed.ncbi.nlm.nih.gov/30887822
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7
2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelinesbiomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays)
Autor: Pekka Kurki, Robert Neely, Akiko Ishii-Watabe, Soma Ray, Yanhua Zhang, Giane Sumner, Susan M. Richards, Lorella Di Donato, Roland F Staack, Charles S Hottenstein, Seongeun Julia Cho, Saloumeh K Fischer, Lauren Stevenson, Jim McNally, Jonathan Haulenbeek, Lilian Yengi, John Smeraglia, Boris Gorovits, Yuanxin Xu, Jenny Hu, Joe Bower, Ashley Mullan, Yan Zhang, Rafiq Islam, Daniel Kramer, Tong-Yuan Yang, John Kadavil, Flora Berisha, Barry van der Strate, Linglong Zou, Laurent Cocea, Kay-Gunnar Stubenrauch, Gerry Kolaitis, Renuka Pillutla, Lakshmi Amaravadi, Thorsten Verch, Chris Beaver, John Kamerud, Marianne Scheel Fjording, Fabio Garofolo, Xuemei Zhao, Yoshiro Saito, Shashi Amur, An Song, Stephen J. Zoog, Kara Scheibner, João Pedras-Vasconcelos, Natasha Savoie, Sam Haidar, Bruce Stouffer, Isabelle Cludts, Binodh DeSilva, Jianing Zeng, Montserrat Carrasco-Triguero, Afshin Safavi, Apollon Papadimitriou, Darshana Jani, Isabella Berger, Michael A Partridge, Jan Welink, Shalini Gupta, Devangi Mehta, Stephen MacMannis, Herbert Birnboeck, Nilufer Tampal, Steven P. Piccoli, Stephanie Fraser
Publikováno v: Bioanalysis. 9(24)
The 2017 11th Workshop on Recent Issues in Bioanalysis took place in Los Angeles/Universal City, California, on 3–7 April 2017 with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology companies
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bf96cba6584d17b853103a8dbb1b10
https://pubmed.ncbi.nlm.nih.gov/29205064
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10
The Gyrolab™ immunoassay system: a platform for automated bioanalysis and rapid sample turnaround
Autor: Matthew Szapacs, Kristy J Fraley, John J Ulicne, Charles S Hottenstein, David Richard Citerone, Lee Abberley
Publikováno v: Bioanalysis. 5:1765-1774
Background: The Gyrolab™ workstation benefits from fully automated transfer of reagents and samples originating from a storage microplate onto a compact disc containing solid-phase microstructures composed of a 15 nl streptavidin-derivitized bead b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457448198bc38d57352c2273137ca5d2
https://doi.org/10.4155/bio.13.145
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