Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Charles S Dela Cruz"'
Autor:
Min Zhao, Pei-Yi Su, Danielle A Castro, Therese N Tripler, Yingxia Hu, Matthew Cook, Albert I Ko, Shelli F Farhadian, Benjamin Israelow, Charles S Dela Cruz, Yong Xiong, Richard E Sutton, Yale IMPACT Research Team
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009683 (2021)
COVID-19 is a global crisis of unimagined dimensions. Currently, Remedesivir is only fully licensed FDA therapeutic. A major target of the vaccine effort is the SARS-CoV-2 spike-hACE2 interaction, and assessment of efficacy relies on time consuming n
Externí odkaz:
https://doaj.org/article/b2383cfe0cfb49c9beaf80ad8a7fdffc
Autor:
Jacob McPadden, Frederick Warner, H Patrick Young, Nathan C Hurley, Rebecca A Pulk, Avinainder Singh, Thomas J S Durant, Guannan Gong, Nihar Desai, Adrian Haimovich, Richard Andrew Taylor, Murat Gunel, Charles S Dela Cruz, Shelli F Farhadian, Jonathan Siner, Merceditas Villanueva, Keith Churchwell, Allen Hsiao, Charles J Torre, Eric J Velazquez, Roy S Herbst, Akiko Iwasaki, Albert I Ko, Bobak J Mortazavi, Harlan M Krumholz, Wade L Schulz
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0243291 (2021)
ObjectiveSevere acute respiratory syndrome virus (SARS-CoV-2) has infected millions of people worldwide. Our goal was to identify risk factors associated with admission and disease severity in patients with SARS-CoV-2.DesignThis was an observational,
Externí odkaz:
https://doaj.org/article/0da76fd3f5204a2cb93cc785db574684
Autor:
Eriko Kudo, Benjamin Israelow, Chantal B F Vogels, Peiwen Lu, Anne L Wyllie, Maria Tokuyama, Arvind Venkataraman, Doug E Brackney, Isabel M Ott, Mary E Petrone, Rebecca Earnest, Sarah Lapidus, M Catherine Muenker, Adam J Moore, Arnau Casanovas-Massana, Yale IMPACT Research Team, Saad B Omer, Charles S Dela Cruz, Shelli F Farhadian, Albert I Ko, Nathan D Grubaugh, Akiko Iwasaki
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000867 (2020)
The current quantitative reverse transcription PCR (RT-qPCR) assay recommended for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing in the United States requires analysis of 3 genomic targets per sample: 2 viral and 1 host. To sim
Externí odkaz:
https://doaj.org/article/5019bd8fc4174e7b8f0a09373261a311
Differential effects of the Akt pathway on the internalization of by lung epithelium and macrophages
Publikováno v:
Innate Immunity, Vol 26 (2020)
Host response to lung infection includes coordinated efforts of multiple cell types, including the lung epithelium and macrophages. Importantly, both the lung epithelium and macrophages can internalize and clear invading pathogens. However, the mecha
Externí odkaz:
https://doaj.org/article/d184db25c3f34051b3ed8858b30babba
Autor:
Zhiqing Xiao, Minggui Lin, Ning Song, Xue Wu, Jingyu Hou, Lili Wang, XinLun Tian, Chunge An, Charles S. Dela Cruz, Lokesh Sharma, De Chang
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110110- (2024)
Summary: Increased cases of sepsis during COVID-19 in the absence of known bacterial pathogens highlighted role of viruses as causative agents of sepsis. In this study, we investigated clinical, laboratory, proteomic, and metabolomic characteristics
Externí odkaz:
https://doaj.org/article/be58ad0fa5954528b2b53cff13599d46
Autor:
Dayna McManus, Matthew W. Davis, Alex Ortiz, Clemente Britto-Leon, Charles S. Dela Cruz, Jeffrey E. Topal
Publikováno v:
Clinics in Chest Medicine. 44:299-319
Publikováno v:
Clinics in Chest Medicine. 44:407-423
Publikováno v:
DNA and Cell Biology. 42:189-193
Autor:
Guang-Shing Cheng, Kristina Crothers, Stefano Aliberti, Anne Bergeron, Michael Boeckh, Jason W. Chien, Catia Cilloniz, Keira Cohen, Nathan Dean, Charles S. Dela Cruz, Robert P. Dickson, Alexander L. Greninger, Chadi A. Hage, Tobias M. Hohl, Steven M. Holland, Barbara E. Jones, Joseph Keane, Mark Metersky, Rachel Miller, Anne Puel, Julio Ramirez, Marcos I. Restrepo, Ajay Sheshadri, Bashar Staitieh, Jeffrey Tarrand, Kevin L. Winthrop, Richard G. Wunderink, Scott E. Evans
Publikováno v:
Annals of the American Thoracic Society. 20:341-353
Publikováno v:
Seminars in Respiratory and Critical Care Medicine. 44:100-117
Coronavirus disease 2019 (COVID-19) pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant mortality in pandemic proportions. Inflammation in response to the infection contributes to the pathogene