Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Charles S, Elmore"'
Autor:
Gabriel M. F. Batista, Ruth Ebenbauer, Craig Day, Jonas Bergare, Karoline T. Neumann, Kathrin H. Hopmann, Charles S. Elmore, Alonso Rosas-Hernández, Troels Skrydstrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Carbon isotope labelling of bioactive molecules is essential for accessing the pharmacokinetic and pharmacodynamic properties of new drug entities. Aryl carboxylic acids represent an important class of structural motifs ubiquitous in pharmac
Externí odkaz:
https://doaj.org/article/e1563e8495164d6896ba652adba48920
Autor:
Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the re
Externí odkaz:
https://doaj.org/article/625cc69bf6ed4690bf32bf9fa866699c
Autor:
Rossana Passannante, Vanessa Gómez-Vallejo, Maialen Sagartzazu-Aizpurua, Laura Vignau Arsuaga, Pablo Marco-Moreno, Garazi Aldanondo, Ainara Vallejo-Illarramendi, Pablo Aguiar, Unai Cossío, Abraham Martín, Jonas Bergare, Lee Kingston, Charles S. Elmore, Miguel Angel Morcillo, Pablo Ferrón, Jesus M. Aizpurua, Jordi Llop
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 253 (2023)
Background and objective: The determination of pharmacokinetic properties of new chemical entities is a key step in the process of drug development. Positron emission tomography (PET) is an ideal technique to obtain both biodistribution and pharmacok
Externí odkaz:
https://doaj.org/article/ed7d132499034dc9b7f57f0c9ecdfc0f
Autor:
Malvika Sardana, Louise Breuil, Sébastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caillé
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1568 (2022)
Crizotinib is a tyrosine kinase inhibitor approved for the treatment of non-small-cell lung cancer, but it is inefficient on brain metastases. Crizotinib is a substrate of the P-glycoprotein, and non-invasive nuclear imaging can be used to assess the
Externí odkaz:
https://doaj.org/article/656bb5c2d5524b698cef9f5f5f03ef39
Autor:
Anton Lindberg, Ryosuke Arakawa, Tsuyoshi Nogami, Sangram Nag, Magnus Schou, Charles S. Elmore, Lars Farde, Victor W. Pike, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-8 (2019)
Abstract Background Over the last decade, a few radioligands have been developed for PET imaging of brain 5-HT1B receptors. The 5-HT1B receptor is a G-protein-coupled receptor (GPCR) that exists in two different agonist affinity states. An agonist li
Externí odkaz:
https://doaj.org/article/10bc2306d18e432dbaa5a6c3fa933174
Autor:
Orlagh M. Feeney, Katie Ardipradja, Ka Fung Noi, Dharmini Mehta, Robert De Rose, Daniel Yuen, Angus P.R. Johnston, Lee Kingston, Cecilia Ericsson, Charles S. Elmore, Richard Hufton, David J. Owen, Marianne B. Ashford, Christopher J.H. Porter
Publikováno v:
Journal of Controlled Release. 348:420-430
As a malignant tumour of lymphatic origin, B-cell lymphoma represents a significant challenge for drug delivery, where effective therapies must access malignant cells in the blood, organs and lymphatics while avoiding off-target toxicity. Subcutaneou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd87b77b5dc91c4fdffa5fa891547b3a
https://doi.org/10.1016/j.jconrel.2022.05.041
https://doi.org/10.1016/j.jconrel.2022.05.041
Synthesis and Preclinical Evaluation of [11C]AZ11895530 for PET Imaging of the Serotonin 1A Receptor
Autor:
Kenneth Dahl, Peter Johnström, Anton Forsberg-Morén, Björn Gustafsson, Patricia Miranda-Azpiazu, Yaser Khani, Christer Halldin, Lars Farde, Charles S. Elmore, Magnus Schou
Publikováno v:
ACS Chemical Neuroscience. 13:2078-2083
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8221d60665ad11b1c81411103d51da12
https://doi.org/10.1021/acschemneuro.2c00205
https://doi.org/10.1021/acschemneuro.2c00205
Publikováno v:
Mühlfenzl, K S, Sardana, M, Skrydstrup, T & Elmore, C S 2022, ' Visible-Light Enabled Late-Stage, Room-Temperature Aminocarbonylation of Aryl Iodides with Labeled Carbon Monoxide ', ChemistrySelect, vol. 7, no. 46, e202203582 . https://doi.org/10.1002/slct.202203582
In recent years, coupling reactions mediated by visible light have been widely studied because such reactions can often be run at significantly lower temperatures. In this work, aryl iodides were coupled with amines at ambient temperature in the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeff371396898e863cc88166edacfbc8
https://pure.au.dk/portal/da/publications/visiblelight-enabled-latestage-roomtemperature-aminocarbonylation-of-aryl-iodides-with-labeled-carbon-monoxide(0149d200-5429-4a04-858e-f16d199a6e96).html
https://pure.au.dk/portal/da/publications/visiblelight-enabled-latestage-roomtemperature-aminocarbonylation-of-aryl-iodides-with-labeled-carbon-monoxide(0149d200-5429-4a04-858e-f16d199a6e96).html
Autor:
Shu-fei Lin PhD, Frederic Bois PhD, Daniel Holden BA, Nabeel Nabulsi PhD, Richard Pracitto MS, Hong Gao MS, Michael Kapinos BS, Jo-ku Teng BS, Anupama Shirali PhD, Jim Ropchan PhD, Richard E. Carson PhD, Charles S. Elmore PhD, Neil Vasdev PhD, Yiyun Huang PhD
Publikováno v:
Molecular Imaging, Vol 16 (2017)
The myriad physiological functions of γ-amino butyric acid (GABA) are mediated by the GABA-benzodiazepine receptor complex comprising of the GABA A , GABA B , and GABA C groups. The various GABA A subunits with region-specific distributions in the b
Externí odkaz:
https://doaj.org/article/497bac56eec240b688692fea73023b35
Autor:
Elmar Zügner, Hsiu-Chiung Yang, Petra Kotzbeck, Beate Boulgaropoulos, Harald Sourij, Sepideh Hagvall, Charles S. Elmore, Russell Esterline, Sven Moosmang, Jan Oscarsson, Thomas R. Pieber, Xiao-Rong Peng, Christoph Magnes
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7966
(1) The cardio-reno-metabolic benefits of the SGLT2 inhibitors canagliflozin (cana), dapagliflozin (dapa), ertugliflozin (ertu), and empagliflozin (empa) have been demonstrated, but it remains unclear whether they exert different off-target effects i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077568d1b6dab0b11bcd16983a9fe3a4