Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Charles R. West"'
Autor:
Chung K. Chu, Konstantine K. Manouilov, Alexander Nechaev, Charles R. West, Alan J. Kirisits, Chung I. Hong, Rakesh Vig
Publikováno v:
Journal of Medicinal Chemistry. 39:1771-1777
A series of the anti-HIV nucleoside conjugates of either (1-O-alkyl) and thioether (1-S-alkyl) lipids linked by a pyrophosphate diester bond has been synthesized as micelle-forming prodrugs of the nucleosides to improve their therapeutic efficiency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea4a74469506843e7c8165fe4831a64
https://doi.org/10.1021/jm950620o
https://doi.org/10.1021/jm950620o
Publikováno v:
Lipids. 28:1021-1026
Four 1-beta-D-arabinofuranosylcytosine conjugates (ara-C) (1a, b and 2a, b) of sn-1 and sn-3 isomers of 1-O-octadecyl-2-O-palmitoylglycerol and its 1-S-alkyl analogue have been synthesized, and their antitumor activity against L1210 lymphoid leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2adadc0ff78a37b67cfc2503429875d
https://doi.org/10.1007/bf02537125
https://doi.org/10.1007/bf02537125
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8636295bb3ec4d45e927ac627c4fd533
https://doi.org/10.1002/chin.199335299
https://doi.org/10.1002/chin.199335299
Publikováno v:
Pain. 48:245-248
We report the successful management of severe, intractable low back pain in a 21-year-old female with an ependymoma of the cauda equina using intermittent intrathecal methylprednisolone (20 mg), bupivacaine (2.5 mg) and morphine (1 mg) injections ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7811635b7436a73c2d2fdec2f74b79
https://doi.org/10.1016/0304-3959(92)90064-i
https://doi.org/10.1016/0304-3959(92)90064-i
Publikováno v:
Journal of Medicinal Chemistry. 33:1380-1386
Five 1-beta-D-arabinofuranosylcytosine conjugates and two cytidine conjugates of thioether lipids (1-S-alkylthioglycerols) linked by a pyrophosphate diester bond have been prepared and their antitumor activity against an ara-C2 sensitive (L1210/0) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75d397cbebdf8395ee5ab4440646a2a
https://doi.org/10.1021/jm00167a016
https://doi.org/10.1021/jm00167a016
Publikováno v:
Journal of medicinal chemistry. 38(10)
A series of ara-CDP-rac-1-O-alkyl-2-O-acylglycerols (9a-f), analogues of highly active ara-CDP-rac-1-O-hexadecyl-2-O-palmitoylglycerol (1) and Cytoros2 (2), was prepared, and solubility, lipophilicity, and structure-activity relationships of these co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe56d9cac24c1d93d49e5280c6a79e7
https://pubmed.ncbi.nlm.nih.gov/7752187
https://pubmed.ncbi.nlm.nih.gov/7752187
Publikováno v:
Journal of medicinal chemistry. 36(12)
A series of ara-CDP-rac-1-S-alkyl-2-O-acyl-1-thioglycerols (3-12), analogues of highly active Cytoros2 (1), was prepared, and solubility, lipophilicity, and structure-activity relationships of these conjugates were investigated. The conjugates with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0755c4b3c18968ab52530f4c42828d6b
https://pubmed.ncbi.nlm.nih.gov/8510106
https://pubmed.ncbi.nlm.nih.gov/8510106
Publikováno v:
Lipids. 26(12)
The 1-beta-D-arabinofuranosylcytosine (ara-C) conjugates 1-O-alkyl (ether) and 1-S-alkyl (thioether) phospholipids, being analogues of ara-CDP-sn-1,2-O-dipalmitoylglycerol (1), showed significant antitumor activity against L1210 and P388 leukemia in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eac9ce601dee15e31b9ddb41452407
https://pubmed.ncbi.nlm.nih.gov/1819747
https://pubmed.ncbi.nlm.nih.gov/1819747
Autor:
Hiroshi Takita, Alfonso M. Bremer, Charles R. West, Jayah Ghoorah, Kazuo Yamada, Hyung C. Park
Publikováno v:
Cancer. 44:2000-2007
Nine patients with intracerebral metastasis from lung carcinoma were treated with intracarotid and intravertebral artery infusion of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Four of these patients considered definite responders showed unequivocal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15e2c1a9d07fba49a3cf586e5abb21eb
https://doi.org/10.1002/1097-0142(197912)44:6<2000::aid-cncr2820440606>3.0.co
https://doi.org/10.1002/1097-0142(197912)44:6<2000::aid-cncr2820440606>3.0.co
Publikováno v:
Journal of Medicinal Chemistry. 22:1428-1432
Two of the new anticancer drugs recently synthesized in our laboratory from conjugation of ara-C2 and several corticosteroids linked through a phosphodiester bond include prednisolone- (I) and prednisone-p-ara-C (II). They were demonstrated to be enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff86adca0b3ca7898a006e1be2ed4e2
https://doi.org/10.1021/jm00197a030
https://doi.org/10.1021/jm00197a030