Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Charles R. Wageman"'
Autor:
Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, usin
Externí odkaz:
https://doaj.org/article/fe16dc1017fe4cafa3021cac90dfb168
Autor:
Pauline W. Ondachi, Hernán A. Navarro, Charles W. Luetje, Michael J. Marks, F. Ivy Carroll, Charles R. Wageman, Ana H. Castro, S. Wayne Mascarella, M. Imad Damaj
Publikováno v:
ACS Chemical Neuroscience. 7:1004-1012
In this study, we report the synthesis, nAChR in vitro and in vivo pharmacological properties of 2'-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues (5, 6a,b, and 7a,b), which are analogues of our lead structure epibatidine. All of the analo
Autor:
Julie M. Miwa, Ryan M. Drenan, Rell L. Parker, Michael J. Marks, Beverley M. Henley, Charles R. Wageman, Sharon R. Grady, Henry A. Lester, Heidi C. O'Neill
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0188715 (2017)
PLoS ONE, Vol 12, Iss 12, p e0188715 (2017)
The α6 nicotinic acetylcholine receptor (nAChR) subunit is an attractive drug target for treating nicotine addiction because it is present at limited sites in the brain including the reward pathway. Lynx1 modulates several nAChR subtypes; lynx1-nACh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19659dfc8d0928faafc81c9ea8553f9
https://resolver.caltech.edu/CaltechAUTHORS:20171211-155148787
https://resolver.caltech.edu/CaltechAUTHORS:20171211-155148787
Autor:
Jerry A. Stitzel, Sharon R. Grady, Charles R. Wageman, Heidi C. O'Neill, S. E. Sherman, Michael J. Marks
Publikováno v:
Genes Brain Behav
A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependenc
Autor:
Hernán A. Navarro, Asti Jackson, F. Ivy Carroll, S. Wayne Mascarella, Charles W. Luetje, Charles R. Wageman, M. Imad Damaj, Ana H. Castro, Michael J. Marks
Publikováno v:
ACS Chemical Neuroscience. 6:920-926
Pyrido[3,4]homotropane (PHT) is a conformationally rigid, high affinity analogue of nicotine. (+)-PHT was previously shown to be 266 times more potent than (-)-PHT for inhibition of [(3)H]epibatidine binding to nAChRs but had no antinociceptive activ
Autor:
Alastair J. King, Natiya E. Robinson, Kayla A. Stehle, Steven M. Garner, Jesse J. Parry, Vanessa L. Norman, Kristin C. Dempsey, Joseph W. Murphy, Charles R. Wageman, Alyssa M. Croff, Lee R. Cavedine, Tracy Lu, Brogan A. Epkins, Victoria V. McBain
Publikováno v:
Cancer Research. 79:2073-2073
Oncology drugs with clinical utility for the treatment of breast cancer span a wide range of different mechanisms and cancer type profiles. Anti-cancer therapies have come a long way from the early use of broad spectrum, cytotoxic agents, with mechan
Autor:
Tracy Lu, Vanessa L. Norman, Lee R. Cavedine, Kayla A. Stehle, Steven M. Garner, Natiya E. Robinson, Alyssa M. Croff, Jesse J. Parry, Victoria V. McBain, Kristin C. Dempsey, Joseph T. Murphy, Charles R. Wageman, Brogan A. Epkins, Alastair J. King
Publikováno v:
Cancer Research. 79:4245-4245
High-throughput, cell-based drug screening platforms are essential to guiding drug discovery programs and can rapidly generate large amounts of pharmacological information about a candidate drug. Drug response data combined with genomic and phenotypi
Autor:
Bruno Tasso, Charles R. Wageman, Fabio Sparatore, Daniela Braida, Sergio Fucile, Sharon R. Grady, Francesco Clementi, Michele Zoli, Luca Pucci, Barbara Loi, Francesca Fasoli, Mariaelvina Sala, Irene Manfredi, Cecilia Gotti, Michael J. Marks
Publikováno v:
British Journal of Pharmacology. 168:835-849
Background and Purpose Many of the addictive and rewarding effects of nicotine are due to its actions on the neuronal nicotinic ACh receptor (nAChR) subtypes expressed in dopaminergic mesocorticolimbic cells. The partial agonists, cytisine and vareni
Autor:
Michael J. Marks, Charles R. Wageman, Sharon R. Grady, Paul Whiteaker, Allan C. Collins, J. Michael McIntosh, Tristan D. McClure-Begley
Publikováno v:
Journal of Neurochemistry. 122:48-57
J. Neurochem. (2012) 122, 48–57. Abstract Mouse superficial superior colliculus (SuSC) contains dense GABAergic innervation and diverse nicotinic acetylcholine receptor subtypes. Pharmacological and genetic approaches were used to investigate the s
Autor:
Natiya E. Robinson, Alyssa M. Croff, Vanessa L. Norman, Alastair J. King, Brogan A. Epkins, Lee R. Cavedine, Steven M. Garner, Jesse J. Parry, Kristin C. Dempsey, Charles R. Wageman, Usha Warrior
Publikováno v:
Cancer Research. 78:2260-2260
Using drug response data, generated by the OncoPanelTM cell-based profiling service, we investigated the differences between traditional and normalized growth rate inhibition (GR) metrics in drug sensitivity classification and predictive genomic biom