Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Charles R. Sanders"'
Publikováno v:
Journal of Structural Biology: X, Vol 9, Iss , Pp 100100- (2024)
NMR spectroscopy has played a pivotal role in fragment-based drug discovery by coupling detection of weak ligand-target binding with structural mapping of the binding site. Fragment-based screening by NMR has been successfully applied to many soluble
Externí odkaz:
https://doaj.org/article/58e477d8954449318196d947b55877a2
Autor:
Anna Clara Miranda Moura, Isaac K. Asare, Mateo Fernandez Cruz, Antonio Javier Franco Aguado, Kaeleigh Dyan Tuck, Conner C. Campbell, Matthew W. Scheyer, Ikponwmosa Obaseki, Steve Alston, Andrea N. Kravats, Charles R. Sanders, Gary A. Lorigan, Indra D. Sahu
Publikováno v:
Membranes, Vol 14, Iss 2, p 45 (2024)
KCNE3 is a single-pass integral membrane protein that regulates numerous voltage-gated potassium channel functions such as KCNQ1. Previous solution NMR studies suggested a moderate degree of curved α-helical structure in the transmembrane domain (TM
Externí odkaz:
https://doaj.org/article/f8ac973c94f44591a95a61186b1b0d48
Autor:
Nico Fricke, Krishnan Raghunathan, Ajit Tiwari, Katherine M. Stefanski, Muthuraj Balakrishnan, Alex G. Waterson, Ricardo Capone, Hui Huang, Charles R. Sanders, Joshua A. Bauer, Anne K. Kenworthy
Publikováno v:
ACS Central Science, Vol 8, Iss 3, Pp 370-378 (2022)
Externí odkaz:
https://doaj.org/article/bcbf6e10de2f41239d8026b4d49b06a3
Autor:
Claire E. DelBove, Claire E. Strothman, Roman M. Lazarenko, Hui Huang, Charles R. Sanders, Qi Zhang
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 449-461 (2019)
The amyloid precursor protein (APP) has been extensively studied because of its association with Alzheimer's disease (AD). However, APP distribution across different subcellular membrane compartments and its function in neurons remains unclear. We ge
Externí odkaz:
https://doaj.org/article/e97467ecd23b4bc3aa7eec42489cd5a4
Autor:
Brett M. Kroncke, Jeffrey Mendenhall, Derek K. Smith, Charles R. Sanders, John A. Capra, Alfred L. George, Jeffrey D. Blume, Jens Meiler, Dan M. Roden
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 206-214 (2019)
Rare variants in the cardiac potassium channel KV7.1 (KCNQ1) and sodium channel NaV1.5 (SCN5A) are implicated in genetic disorders of heart rhythm, including congenital long QT and Brugada syndromes (LQTS, BrS), but also occur in reference population
Externí odkaz:
https://doaj.org/article/92da0d6e0dad4f20bb9ebe8b1ec0efbb
Autor:
Isaac K. Asare, Alberto Perez Galende, Andres Bastidas Garcia, Mateo Fernandez Cruz, Anna Clara Miranda Moura, Conner C. Campbell, Matthew Scheyer, John Paul Alao, Steve Alston, Andrea N. Kravats, Charles R. Sanders, Gary A. Lorigan, Indra D. Sahu
Publikováno v:
Membranes, Vol 12, Iss 5, p 469 (2022)
KCNE3 is a potassium channel accessory transmembrane protein that regulates the function of various voltage-gated potassium channels such as KCNQ1. KCNE3 plays an important role in the recycling of potassium ion by binding with KCNQ1. KCNE3 can be fo
Externí odkaz:
https://doaj.org/article/611b6e3967204d6eae590330c9a4c38e
Autor:
Kathryn R. Brewer, Georg Kuenze, Carlos G. Vanoye, Alfred L. George, Jens Meiler, Charles R. Sanders
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The cardiac action potential is critical to the production of a synchronized heartbeat. This electrical impulse is governed by the intricate activity of cardiac ion channels, among them the cardiac voltage-gated potassium (Kv) channels KCNQ1 and hERG
Externí odkaz:
https://doaj.org/article/9513fb6290644222a02f780f87dc44b7
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 4, p e1010038 (2022)
Recent advances in experimental and computational protein structure determination have provided access to high-quality structures for most human proteins and mutants thereof. However, linking changes in structure in protein mutants to functional impa
Externí odkaz:
https://doaj.org/article/1f65416cef8842b48e5fb3c0a0a06b46
Autor:
Georg Kuenze, Carlos G Vanoye, Reshma R Desai, Sneha Adusumilli, Kathryn R Brewer, Hope Woods, Eli F McDonald, Charles R Sanders, Alfred L George Jr, Jens Meiler
Publikováno v:
eLife, Vol 9 (2020)
The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, IKs, which contributes to the repolarization phase of the cardiac ac
Externí odkaz:
https://doaj.org/article/eb5503437d7d4717b295c6786fb43fec
Autor:
Keenan C Taylor, Po Wei Kang, Panpan Hou, Nien-Du Yang, Georg Kuenze, Jarrod A Smith, Jingyi Shi, Hui Huang, Kelli McFarland White, Dungeng Peng, Alfred L George, Jens Meiler, Robert L McFeeters, Jianmin Cui, Charles R Sanders
Publikováno v:
eLife, Vol 9 (2020)
Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and activated. Experimental determination of the structure of a potassium channel VSD in the interme
Externí odkaz:
https://doaj.org/article/ee10c6d390644901b22e9bb15828c3d3