Výsledky vyhledávání - "Charles R. K. Changunda"

Synthesis of novel pyridine and pyrimidine derivatives as potential inhibitors of HIV-1 reverse transcriptase using palladium-catalysed C-N cross-coupling and nucleophilic aromatic substitution reactions

Autor: Amanda L. Rousseau, Adriaan E. Basson, Moira L. Bode, Charles R. K. Changunda

Publikováno v: Arkivoc. 2020:152-170

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95d2393a79fc1d7265001dc55b111289
https://doi.org/10.24820/ark.5550190.p011.282

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Efficient one-pot synthesis of functionalised imidazo[1,2-a]pyridines and unexpected synthesis of novel tetracyclic derivatives by nucleophilic aromatic substitution

Autor: Charles R. K. Changunda, B. C. Venkatesh, William K. Mokone, Amanda L. Rousseau, Moira L. Bode, Dean Brady, Manuel A. Fernandes

Publikováno v: RSC Advances. 10:8104-8114

Novel tetracyclic imidazo[1,2-a]pyridine derivatives have been prepared by intramolecular nucleophilic aromatic substitution of 5-fluoroimidazo[1,2-a]pyridines under basic conditions. Use of the non-nucleophilic alcoholic solvent tert-butanol, rather

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd71fa3ca520e535c86dc6e8602d6597
https://doi.org/10.1039/c9ra10447j

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Palladium-catalysed cross-coupling as a key step in the synthesis of pyridyl-benzamides, -benzylamines and -sulfonamides

Autor: Charles R. K. Changunda, Sandy van Vuuren, Moira L. Bode, Adriaan E. Basson, Amanda L. Rousseau

Publikováno v: Tetrahedron. 73:137-147

Novel N-, O- and S-substituted pyridyl-benzamides, -benzylamines and -sulfonamides were prepared by means of palladium-catalysed cross-coupling reactions. The synthetic approach, using Pd2(dba)3 as palladium source and rac-BINAP as supporting ligand,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::727d4993f7790e89ca555aa4ce5af8f8
https://doi.org/10.1016/j.tet.2016.11.071

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