Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Charles R. Harrington"'
Autor:
Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik, Andrew Porter, Soumya Palliyil
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that can detect early signs of Alzheimer’s disease (AD). Recent successes in the development of amyloid-targetin
Externí odkaz:
https://doaj.org/article/3efb8c85249a4d3e81c8e65617f504f9
Autor:
Karima Schwab, Lianne Robinson, Anne Annschuetz, Eline Dreesen, Mandy Magbagbeolu, Valeria Melis, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel
Publikováno v:
Brain Research Bulletin, Vol 220, Iss , Pp 111172- (2025)
The negative interference of treatments between the acetylcholinesterase inhibitor rivastigmine and the tau aggregation inhibitor hydromethylthionine mesylate (HMTM) has been reported in Line 1 tau-transgenic mice, which overexpress a truncated speci
Externí odkaz:
https://doaj.org/article/17ae88b80a4c4ab98d2cc2893ad6f909
Autor:
Lewis K. Penny, Richard Lofthouse, Mohammad Arastoo, Andy Porter, Soumya Palliyil, Charles R. Harrington, Claude M. Wischik
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies for Alzheimer’s disease (AD). The designs have ensured the correct selection of patients on these trials, supported targe
Externí odkaz:
https://doaj.org/article/73f382a2bce1401e95495cc3facd6bb0
Autor:
Karima Schwab, Mandy Magbagbeolu, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The accumulation of α-synuclein (α-Syn) into Lewy bodies is a hallmark of synucleinopathies, a group of neurological disorders that include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Small oligomers as well as larger f
Externí odkaz:
https://doaj.org/article/1ad118a61c2b453db472d785f41f7ed3
Autor:
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R. Harrington, Claude M. Wischik, Grażyna Niewiadomska, Gernot Riedel
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110955- (2024)
In clinical trials for Alzheimer’s disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as m
Externí odkaz:
https://doaj.org/article/55dcde6ffee8464392a774ea753330c1
Autor:
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska
Publikováno v:
Cells, Vol 13, Iss 7, p 642 (2024)
Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the
Externí odkaz:
https://doaj.org/article/08f2654462fb4a6f97b2a4c2ca2ac9d8
Autor:
Youssra K. Al-Hilaly, Connor Hurt, Janet E. Rickard, Charles R. Harrington, John M. D. Storey, Claude M. Wischik, Louise C. Serpell, Ansgar B. Siemer
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Aggregation of the tau protein into fibrillar cross-β aggregates is a hallmark of Alzheimer’s diseases (AD) and many other neurodegenerative tauopathies. Recently, several core structures of patient-derived tau paired helical filaments (PHFs) have
Externí odkaz:
https://doaj.org/article/594cc6b618014d32a8d39a0d9b3fe5ca
Autor:
Alex Zabala-Findlay, Lewis K. Penny, Richard A. Lofthouse, Andrew J. Porter, Soumya Palliyil, Charles R. Harrington, Claude M. Wischik, Mohammad Arastoo
Publikováno v:
Cells, Vol 12, Iss 8, p 1184 (2023)
Objectives: With the development of new technologies capable of detecting low concentrations of Alzheimer’s disease (AD) relevant biomarkers, the idea of a blood-based diagnosis of AD is nearing reality. This study aims to consider the evidence of
Externí odkaz:
https://doaj.org/article/54645bfccaff4fddaeb74228191eca5f
Autor:
Mar Pacheco-Herrero, Luis O. Soto-Rojas, Charles R. Harrington, Yazmin M. Flores-Martinez, Marcos M. Villegas-Rojas, Alfredo M. León-Aguilar, Paola A. Martínez-Gómez, B. Berenice Campa-Córdoba, Ricardo Apátiga-Pérez, Carolin N. Corniel-Taveras, Jesabelle de J. Dominguez-García, Víctor Manuel Blanco-Alvarez, José Luna-Muñoz
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus disease 2019 (COVID-19) has caused about 114 million accumulated cases and 2
Externí odkaz:
https://doaj.org/article/220b3a0a52034b53b47f7604cb0abd3c
Autor:
Nabil Itzi Luna-Viramontes, B. Berenice Campa-Córdoba, Miguel Ángel Ontiveros-Torres, Charles R. Harrington, Ignacio Villanueva-Fierro, Parménides Guadarrama-Ortíz, Linda Garcés-Ramírez, Fidel de la Cruz, Mario Hernandes-Alejandro, Sandra Martínez-Robles, Erik González-Ballesteros, Mar Pacheco-Herrero, José Luna-Muñoz
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Worldwide, around 50 million people have dementia. Alzheimer’s disease (AD) is the most common type of dementia and one of the major causes of disability and dependency among the elderly worldwide. Clinically, AD is characterized by impaired memory
Externí odkaz:
https://doaj.org/article/1325dc9dc34047ac96e319586e159d02