Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Charles R. Dixon"'
Autor:
Rafal Czapiewski, Dzmitry G. Batrakou, Jose I. de las Heras, Roderick N. Carter, Aishwarya Sivakumar, Magdalena Sliwinska, Charles R. Dixon, Shaun Webb, Giovanna Lattanzi, Nicholas M. Morton, Eric C. Schirmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Little is known how spatial genome organization is directed in fat; however, key proadipogenic genes reposition from the nuclear envelope (NE) to the interior during adipogenesis. Here the authors show that deletion of NE protein Tmem120a in adipocyt
Externí odkaz:
https://doaj.org/article/5efba97324ba4758897fa78e06687621
Autor:
Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103055- (2021)
Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://doaj.org/article/7c77bb3feb48478187feaae2f2cec97e
Autor:
Peter Meinke, Alastair R.W. Kerr, Rafal Czapiewski, Jose I. de las Heras, Charles R. Dixon, Elizabeth Harris, Heike Kölbel, Francesco Muntoni, Ulrike Schara, Volker Straub, Benedikt Schoser, Manfred Wehnert, Eric C. Schirmer
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: As genome-wide approaches prove difficult with genetically heterogeneous orphan diseases, we developed a new approach to identify candidate genes. We applied this to Emery-Dreifuss muscular dystrophy (EDMD), characterised by early onset c
Externí odkaz:
https://doaj.org/article/e946bd122b21483d83d43af02176d4fb
Autor:
Natalia Saiz-Ros, Rafal Czapiewski, Ilaria Epifano, Andrew Stevenson, Selene K. Swanson, Charles R. Dixon, Dario B. Zamora, Marion McElwee, Swetha Vijayakrishnan, Christine A. Richardson, Li Dong, David A. Kelly, Lior Pytowski, Martin W. Goldberg, Laurence Florens, Sheila V. Graham, Eric C. Schirmer
Publikováno v:
Cells, Vol 8, Iss 2, p 120 (2019)
The primary envelopment/de-envelopment of Herpes viruses during nuclear exit is poorly understood. In Herpes simplex virus type-1 (HSV-1), proteins pUL31 and pUL34 are critical, while pUS3 and some others contribute; however, efficient membrane fusio
Externí odkaz:
https://doaj.org/article/c41c1533b52c4d7e86870eed76c105f9
Autor:
Sheila Webb, de las Heras Ji, Rafal Czapiewski, Giovanna Lattanzi, Dzmitry G. Batrakou, Charles R. Dixon, Eric C. Schirmer, Nik M. Morton, Sliwinska M, Aishwarya Sivakumar, Carter Rn
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Czapiewski, R, Batrakou, D G, de las Heras, J, Nicholas Carter, R, Sivakumar, A, Sliwinska, M, Dixon, C, Webb, S, Lattanzi, G, Morton, N M & Schirmer, E C 2022, ' Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy ', Nature Communications, vol. 13, no. 1, 321 . https://doi.org/10.1038/s41467-021-27869-2
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Czapiewski, R, Batrakou, D G, de las Heras, J, Nicholas Carter, R, Sivakumar, A, Sliwinska, M, Dixon, C, Webb, S, Lattanzi, G, Morton, N M & Schirmer, E C 2022, ' Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy ', Nature Communications, vol. 13, no. 1, 321 . https://doi.org/10.1038/s41467-021-27869-2
Little is known about how the observed fat-specific pattern of 3D-spatial genome organisation is established. Here we report that adipocyte-specific knockout of the gene encoding nuclear envelope transmembrane protein Tmem120a disrupts fat genome org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a26f1720d339a4c3da5dbed9a5c707
http://europepmc.org/articles/PMC8758788
http://europepmc.org/articles/PMC8758788
Autor:
Greg J. Towers, Eleanor Gaunt, Natalia Saiz-Ros, A. Christine Richardson, David A. Kelly, Jose I. de las Heras, Eric C. Schirmer, Charles R. Dixon, Poonam Malik, Weidong Yang, Juri Rappsilber, Mark Tingey, Martin W. Goldberg, Flavia de Lima Alves, Paul Digard
Publikováno v:
Dixon, C, Malik, P, de las Heras, J, Saiz ros, N, Alves, F L, Tingey, M, Gaunt, E, Richardson, A C, Kelly, D, Goldberg, M, Towers, G J, Yang, W, Rappsilber, J, Digard, P & Schirmer, E C 2021, ' STING Nuclear Partners Contribute to Innate Immune Signalling Responses ', iScience . https://doi.org/10.1016/j.isci.2021.103055
iScience, Vol 24, Iss 9, Pp 103055-(2021)
iScience
iScience, 2021, Vol.24(9) [Peer Reviewed Journal]
iScience, Vol 24, Iss 9, Pp 103055-(2021)
iScience
iScience, 2021, Vol.24(9) [Peer Reviewed Journal]
Summary STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b5722e4a4f0e8e3aae8d553bcc61b4
https://www.pure.ed.ac.uk/ws/files/226478012/1_s2.0_S2589004221010233_main.pdf
https://www.pure.ed.ac.uk/ws/files/226478012/1_s2.0_S2589004221010233_main.pdf
Autor:
Eric C. Schirmer, E. Harris, Ulrike Schara, Manfred Wehnert, Benedikt Schoser, Peter Meinke, Alastair R.W. Kerr, Francesco Muntoni, Heike Kölbel, Volker Straub, Rafal Czapiewski, Charles R. Dixon, Jose I. de las Heras
Publikováno v:
EBioMedicine, Vol 51, Iss, Pp-(2020)
EBioMedicine
EBioMedicine
Background: As genome-wide approaches prove difficult with genetically heterogeneous orphan diseases, we developed a new approach to identify candidate genes. We applied this to Emery-Dreifuss muscular dystrophy (EDMD), characterised by early onset c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef5dfbe22018adf60bcf53a27619802
http://www.sciencedirect.com/science/article/pii/S2352396419307972
http://www.sciencedirect.com/science/article/pii/S2352396419307972
Autor:
Eric C. Schirmer, Charles R. Dixon
Publikováno v:
Nucleic Acids and Molecular Biology ISBN: 9783319773087
Several different mechanisms have been proposed for how membrane proteins access the inner nuclear membrane. These include mechanisms using both the central and peripheral channels of the nuclear pore complexes that involve free diffusion in the memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98d3a23329f02eb1bb80d48a4a175b6
https://doi.org/10.1007/978-3-319-77309-4_7
https://doi.org/10.1007/978-3-319-77309-4_7
Autor:
Ilaria Epifano, Natalia Saiz-Ros, Andrew Stevenson, Swetha Vijayakrishnan, Pytowski L, Martin W. Goldberg, Christine Richardson, Eric C. Schirmer, Sheila V. Graham, Rafal Czapiewski, Charles R. Dixon, Marion McElwee, Laurence Florens, Selene K. Swanson
The herpesvirus process of primary envelopment and de-envelopment as viral particles exit the nucleus has been for many years one of the least understood steps in the virus life cycle. Though viral proteins such as pUL31, pUL34, pUS3 and others are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5332104d5c5313ea6544d05a03644655
https://doi.org/10.1101/088633
https://doi.org/10.1101/088633