Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Charles R Mackay"'
Autor:
Bing H. Wang, Remy Robert, Francine Z. Marques, Niwanthi Rajapakse, Helen Kiriazis, Charles R. Mackay, David M. Kaye
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis. Here we tested the hypothesis that CXCR7, a highly conserved chemokine receptor, contr
Externí odkaz:
https://doaj.org/article/39ae76b2ee2b4c3481cce768b048591b
Autor:
Remy Robert, Laurent Juglair, Ee X Lim, Caroline Ang, Carl J H Wang, Gregor Ebert, Olan Dolezal, Charles R Mackay
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184278 (2017)
Chemokines and their receptors are pivotal for the trafficking of leukocytes during immune responses, and host defense. However, immune cell migration also contributes to a wide variety of autoimmune and chronic inflammatory diseases. Compelling evid
Externí odkaz:
https://doaj.org/article/8708c0d0b60b4ff4808743979a159753
Autor:
Marjon E Kamp, Raymond Shim, Alyce J Nicholls, Ana Carolina Oliveira, Linda J Mason, Lauren Binge, Charles R Mackay, Connie H Y Wong
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163750 (2016)
Fermentation of dietary fibre in the gut yields large amounts of short chain fatty acids (SCFAs). SCFAs can impart biological responses in cells through their engagement of 'metabolite-sensing' G protein-coupled receptors (GPCRs). One of the main SCF
Externí odkaz:
https://doaj.org/article/ae5ba4c8c23c4e828c33da5498c7dcb2
Autor:
Jenny E Gunton, Mary Sisavanh, Rebecca A Stokes, Jon Satin, Leslie S Satin, Min Zhang, Sue M Liu, Weikang Cai, Kim Cheng, Gregory J Cooney, D Ross Laybutt, Trina So, Juan-Carlos Molero, Shane T Grey, Douglas A Andres, Michael S Rolph, Charles R Mackay
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39462 (2012)
AIMS AND HYPOTHESIS:Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely
Externí odkaz:
https://doaj.org/article/7e888d5d96f54d44a11c04ca0d7a1069
Autor:
Malcolm R Starkey, Richard Y Kim, Emma L Beckett, Heidi C Schilter, Doris Shim, Ama-Tawiah Essilfie, Duc H Nguyen, Kenneth W Beagley, Joerg Mattes, Charles R Mackay, Jay C Horvat, Philip M Hansbro
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42588 (2012)
BACKGROUND: Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and
Externí odkaz:
https://doaj.org/article/bdcea32bb868477696ff5bfab351d106
Autor:
Kirstine J. Bell, Sonia Saad, Bree J. Tillett, Helen M. McGuire, Sara Bordbar, Yu Anne Yap, Long T. Nguyen, Marc R. Wilkins, Susan Corley, Shannon Brodie, Sussan Duong, Courtney J. Wright, Stephen Twigg, Barbara Fazekas de St Groth, Leonard C. Harrison, Charles R. Mackay, Esteban N. Gurzov, Emma E. Hamilton-Williams, Eliana Mariño
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-21 (2022)
Abstract Background Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteri
Externí odkaz:
https://doaj.org/article/e25eb74805594ff78c91c45cb9747d55
Autor:
Peter J. Vuillermin, Martin O’Hely, Fiona Collier, Katrina J. Allen, Mimi L. K. Tang, Leonard C. Harrison, John B. Carlin, Richard Saffery, Sarath Ranganathan, Peter D. Sly, Lawrence Gray, John Molloy, Angela Pezic, Michael Conlon, David Topping, Karen Nelson, Charles R. Mackay, Laurence Macia, Jennifer Koplin, Samantha L. Dawson, Margarita Moreno-Betancur, Anne-Louise Ponsonby, the J. Craig Venter Institute, the BIS Investigator Group
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Incidence of food allergy in westernized populations is associated with low abundance of Prevotella. Here, the authors analyse the microbiome of a mother-infant prebirth cohort and find that maternal carriage, but not infant carriage, of P. copri dur
Externí odkaz:
https://doaj.org/article/48c619686c2c46b9920e7b85a53be041
Publikováno v:
The Journal of Immunology. 210:1629-1639
Nonpathogenic commensal microbiota and their metabolites and components are essential to maintain a tolerogenic environment and promote beneficial health effects. The metabolic environment critically impacts the outcome of immune responses and likely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f924e2d1042cd18e6f053b370c9930
https://doi.org/10.4049/jimmunol.2300016
https://doi.org/10.4049/jimmunol.2300016
Autor:
Mingjing Hu, David Eviston, Peter Hsu, Eliana Mariño, Ann Chidgey, Brigitte Santner-Nanan, Kahlia Wong, James L. Richards, Yu Anne Yap, Fiona Collier, Ann Quinton, Steven Joung, Michael Peek, Ron Benzie, Laurence Macia, David Wilson, Ann-Louise Ponsonby, Mimi L. K. Tang, Martin O’Hely, Norelle L. Daly, Charles R. Mackay, Jane E. Dahlstrom, The BIS Investigator Group, Peter Vuillermin, Ralph Nanan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Maternal immunological dysregulation might affect the immunological development of the fetus. Here the authors show that decreased maternal acetate is associated with preeclampsia, impaired fetal thymic output and regulatory T cell development.
Externí odkaz:
https://doaj.org/article/c9a435d8124048e595fe54577e177533
Autor:
Krist Helen Antunes, José Luís Fachi, Rosemeire de Paula, Emanuelle Fraga da Silva, Laís Passariello Pral, Adara Áurea dos Santos, Greicy Brisa Malaquias Dias, José Eduardo Vargas, Renato Puga, Fabiana Quoos Mayer, Fábio Maito, Carlos R. Zárate-Bladés, Nadim J. Ajami, Marcella Ramos Sant’Ana, Thamiris Candreva, Hosana Gomes Rodrigues, Marcio Schmiele, Maria Teresa Pedrosa Silva Clerici, José Luiz Proença-Modena, Angélica Thomas Vieira, Charles R. Mackay, Daniel Mansur, Mauricio T. Caballero, Jacqui Marzec, Jianying Li, Xuting Wang, Douglas Bell, Fernando P. Polack, Steven R. Kleeberger, Renato T. Stein, Marco Aurélio Ramirez Vinolo, Ana Paula Duarte de Souza
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Dietary fibers and SCFAs can exert a protective effect against respiratory syncytial virus (RSV). Here, the authors report that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in
Externí odkaz:
https://doaj.org/article/c60e76919412482d9d4459cf276f5674