Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Charles R Evans"'
Autor:
Hiroyuki Mori, Colleen E Dugan, Akira Nishii, Ameena Benchamana, Ziru Li, Thomas S Cadenhead, Arun K Das, Charles R Evans, Katherine A Overmyer, Steven M Romanelli, Sydney K Peterson, Devika P Bagchi, Callie A Corsa, Julie Hardij, Brian S Learman, Mahmoud El Azzouny, Joshua J Coon, Ken Inoki, Ormond A MacDougald
Publikováno v:
PLoS Biology, Vol 19, Iss 5, p e3000988 (2021)
Although visceral adipocytes located within the body's central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at cooler te
Externí odkaz:
https://doaj.org/article/0a2c69a31868454387b35182f8affd1f
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117232 (2015)
A critical application of metabolomics is the evaluation of tissues, which are often the primary sites of metabolic dysregulation in disease. Laboratory rodents have been widely used for metabolomics studies involving tissues due to their facile hand
Externí odkaz:
https://doaj.org/article/a0e8e81ff1954734a38266a04029e618
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129029 (2015)
AMPK regulates many metabolic pathways including fatty acid and glucose metabolism, both of which are closely associated with insulin secretion in pancreatic β-cells. Insulin secretion is regulated by metabolic coupling factors such as ATP/ADP ratio
Externí odkaz:
https://doaj.org/article/e6940bef706c40c6ac7706b36b92e704
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19710 (2011)
NAD(+) is both a co-enzyme for hydride transfer enzymes and a substrate of sirtuins and other NAD(+) consuming enzymes. NAD(+) biosynthesis is required for two different regimens that extend lifespan in yeast. NAD(+) is synthesized from tryptophan an
Externí odkaz:
https://doaj.org/article/7cb4c44855ef40bf95b7543128eb6196
Autor:
Hyo Sub Choi, Ajay Bhat, Marshall B. Howington, Megan L. Schaller, Rebecca L. Cox, Shijiao Huang, Safa Beydoun, Hillary A. Miller, Angela M. Tuckowski, Joy Mecano, Elizabeth S. Dean, Lindy Jensen, Daniel A. Beard, Charles R. Evans, Scott F. Leiser
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress r
Externí odkaz:
https://doaj.org/article/2e4a51166bab49ee8b478a87ad3ac370
Autor:
Hani Habra, Jennifer L. Meijer, Tong Shen, Oliver Fiehn, David A. Gaul, Facundo M. Fernández, Kaitlin R. Rempfert, Thomas O. Metz, Karen E. Peterson, Charles R. Evans, Alla Karnovsky
Publikováno v:
Metabolites, Vol 14, Iss 2, p 125 (2024)
Liquid chromatography–high-resolution mass spectrometry (LC-HRMS), as applied to untargeted metabolomics, enables the simultaneous detection of thousands of small molecules, generating complex datasets. Alignment is a crucial step in data processin
Externí odkaz:
https://doaj.org/article/ab4466185f434c298b44e5983418504f
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Autor:
Theodore S. Jennaro, PharmD, Michael A. Puskarich, MD, MS, Charles R. Evans, PhD, Alla Karnovsky, PhD, Thomas L. Flott, BA, Laura A. McLellan, BSc, Alan E. Jones, MD, Kathleen A. Stringer, PharmD
Publikováno v:
Critical Care Explorations, Vol 5, Iss 4, p e0881 (2023)
OBJECTIVES:. Perturbed host metabolism is increasingly recognized as a pillar of sepsis pathogenesis, yet the dynamic alterations in metabolism and its relationship to other components of the host response remain incompletely understood. We sought to
Externí odkaz:
https://doaj.org/article/418cd2c200b944379f9e41ea174c4400
Publikováno v:
The Astrophysical Journal, Vol 952, Iss 1, p 87 (2023)
With the precision now afforded by modern space-based photometric observations from the retired K2 and current TESS missions, the effects of general relativity (GR) may be detectable in the light curves of pulsating white dwarfs (WDs). Almost all WD
Externí odkaz:
https://doaj.org/article/12ffb9137cf641bbb6324e53eb1e2ce6
Autor:
Xiaoxi Xu, Anoop Arunagiri, Maroof Alam, Leena Haataja, Charles R. Evans, Ivy Zhao, Roberto Castro-Gutierrez, Holger A. Russ, Caroline Demangel, Ling Qi, Billy Tsai, Ming Liu, Peter Arvan
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2023, pp.104836. ⟨10.1016/j.jbc.2023.104836⟩
Journal of Biological Chemistry, 2023, pp.104836. ⟨10.1016/j.jbc.2023.104836⟩
International audience; Insulin is made from proinsulin, but the extent to which fasting/feeding controls the homeostatically-regulated proinsulin pool in pancreatic β-cells remains largely unknown. Here, we first examined β-cell lines (INS1E and M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a02a0046fb7b5d4e043e93e2a85b77b
https://hal-pasteur.archives-ouvertes.fr/pasteur-04135046
https://hal-pasteur.archives-ouvertes.fr/pasteur-04135046
