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pro vyhledávání: '"Charles Prince Zuta"'
Autor:
Lauren Hamilton, Rene Onrust, Thomas Neil Wheeler, Charles Prince Zuta, Sasha Gragerov, Alex Rohde, Shawn McKee, Neil S. Cutshall, Jennifer Lynn Gage, Vince Florio, Harbol Kevin L, Galina Gragerova, Hui-Rong Shen
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(17)
A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine