Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Charles Pidgeon"'
Publikováno v:
ADMET and DMPK, Vol 5, Iss 1, Pp 14-38 (2017)
The drug discovery process can be accelerated by chromatographic profiling of the analogs to model in vivo distribution and the major non-specific binding. A balanced potency and chromatographically determined membrane and protein binding (IAM MB/PB)
Externí odkaz:
https://doaj.org/article/a29c5ad30ea64a099af98ff95d72f461
Autor:
Charles Pidgeon
Publikováno v:
Research and Reviews on Healthcare: Open Access Journal. 5
Today, the COVID-19 problem has raised social consequences more than any time in modern society. Few, if any believe...
Autor:
Charles Pidgeon, PhD
Dr. Pidgeon is a UCSF graduate in pharmaceutical chemistry. He is most known in the pharmaceutical drug discovery process for immobilized artificial membrane (IAM) technology that was commercialized and is used today in big pharma thirty years after
Autor:
Charles Pidgeon, PhD, Sehej Bindra
Tactile sensations are well studied, and much is known about this sensory system. The complexity is difficult to learn because of the breadth of information available. The approach of this book was to inform interested readers about this system th
Autor:
Jason Yang, Charles Pidgeon
Vision Facts is a question and answer guide to the wonders of the human eye, its complex structures and the process of visual perception. It traces the journey of vision from a ray of light entering the eye to the processing done by the brain, to the
Publikováno v:
ADMET and DMPK, Vol 5, Iss 1, Pp 14-38 (2017)
ADMET and DMPK
Volume 5
Issue 1
ADMET and DMPK
Volume 5
Issue 1
The drug discovery process can be accelerated by chromatographic profiling of the analogs to model in vivo distribution and the major non-specific binding. A balanced potency and chromatographically determined membrane and protein binding (IAM MB/PB)
Publikováno v:
Biochemistry. 38:4875-4884
Primary rate and equilibrium parameters for 60 site-directed mutants of bovine pancreatic phospholipase A2 (PLA2) are analyzed so incremental contributions of the substitution of specific residues can be evaluated. The magnitude of the change is eval
Publikováno v:
Pharmaceutical Research. 16:1331-1343
The intestinal peptide transport system has broad substrate specificities. In addition to its physiological function of absorbing di- and tripeptides resulting from the digestion of dietary proteins, this transport system also absorbs some orally adm
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 703:53-62
Aldolase B is a peripheral membrane protein. Immobilized artificial membrane (IAM) surfaces were used to purify rat liver aldolase B in a single chromatographic step. Selective elution required dipalmitoylphosphatidylcholine (DPPC) to be included in
Publikováno v:
Advanced Drug Delivery Reviews. 23:229-256
Immobilized Artificial Membranes (IAMs) are monolayers of phospholipid analogs covalently bonded to the surface of silica particles. 31P NMR and molecular dynamics (MD) simulations demonstrated that IAMs and liposome membranes exhibit similar interfa