Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Charles Pally"'
The Chemokine Receptor Cxcr3 Is Not Essential for Acute Cardiac Allograft Rejection in Mice and Rats
Autor:
Hans-Günter Zerwes, L. Roth, M. Luyten, M B. Streiff, Charles Pally, R. Bänteli, Robert P. Loewe, Grazyna Wieczorek, J. Li, M. Hofmann, J. Kovarik, Gebhard Thoma, Bruno Luckow
Publikováno v:
American Journal of Transplantation. 8:1604-1613
Chemokine receptors have gained attention as potential targets for novel therapeutic strategies. We investigated the mechanisms of allograft rejection in chemokine receptor Cxcr3-deficient mice using a model of acute heart allograft rejection in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2563c7a7bb766d3a5a1212fe1d6d5abd
https://doi.org/10.1111/j.1600-6143.2008.02309.x
https://doi.org/10.1111/j.1600-6143.2008.02309.x
Autor:
Marcel Luyten, Ryosei Kawai, Charles Pally, Hans-Günter Zerwes, Edgar Käslin, Bernd Klanke, Matthias Hofmann
Publikováno v:
Drug Development Research. 63:54-65
We have developed a novel and noninvasive animal model in which the activity of a marker enzyme in plasma is used to measure endothelial cell activation. Secreted heat-stable human placental alkaline phosphatase (SeAP) was placed under the transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::538e36426c6bd45ea1c34ebd010483d6
https://doi.org/10.1002/ddr.10397
https://doi.org/10.1002/ddr.10397
Publikováno v:
Transplantation. 72:1776-1783
Background, ERL is the enteric-coated sodium salt of mycophenolic acid, presently in clinical development. The drug substance mycophenolate sodium (MPS) was evaluated in rat transplantation models and compared with mycophenolate mofetil (MMF) for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5863afd701a994bfb05b47b7a3f9daeb
https://doi.org/10.1097/00007890-200112150-00011
https://doi.org/10.1097/00007890-200112150-00011
Autor:
Charles Pally, Edo O. Schraa, Tanja Kobel, Hans-Günter Zerwes, Marc Bigaud, Emile Andriambeloson, Valerie Lobstein
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 21:67-73
Abstract —Clinical evidence suggests that early endothelial cell (EC) dysfunction may predict the development of graft vascular disease. We wished to assess the early functional and morphological changes in the graft endothelium in a commonly used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c083290585e22ac38ffc1009bd4d21
https://doi.org/10.1161/01.atv.21.1.67
https://doi.org/10.1161/01.atv.21.1.67
COMPLETE LOSS OF FUNCTIONAL SMOOTH MUSCLE CELLS PRECEDES VASCULAR REMODELING IN RAT AORTA ALLOGRAFTS
Autor:
Christian Bruns, Charles Pally, Hans-G nter Zerwes, Emile Andriambeloson, Valerie Lobstein, Marc Bigaud, Edo O. Schraa, Tanja Kobel
Publikováno v:
Transplantation. 68:1701-1707
modeling because they have several advantages over models of solid organ transplantation (Tx), i.e., easier surgical pro- cedures as well as fast readout. Moreover, the specific mor- phological/histological changes in the vessel wall can be mon- itor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab09cfeeb19783924bb0a78687e97d7f
https://doi.org/10.1097/00007890-199912150-00013
https://doi.org/10.1097/00007890-199912150-00013
Autor:
Peter Nussbaumer, Karl Welzenbach, Markus Streiff, Klemens Högenauer, Andreas Billich, Trixie Wagner, Charles Pally
Publikováno v:
ChemMedChem. 3:1027-1029
active principle (S)-FTY720-phosphate which binds to four of the five known sphingosine-1-phosphate receptors (S1P1–5). It has been convincingly demonstrated that the immunomodulatory effect is primarily mediated by S1P1. Sphingosine kinases (SPHKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e29fd5c948ef1dab24c27a5e5686f0
https://doi.org/10.1002/cmdc.200800037
https://doi.org/10.1002/cmdc.200800037
Autor:
Lukas Oberer, Birgit Bollbuck, Frederic Bassilana, Peter Buehlmayer, Frederic Berst, Markus Streiff, Charles Pally, Christian Beerli, Rene Hersperger, Christian Bruns, Philipp Janser, Jean Quancard, Daniela Angst
Publikováno v:
Journal of medicinal chemistry. 55(22)
A prodrug approach to optimize the oral exposure of a series of sphingosine 1-phosphate receptor 1 (S1P(1)) antagonists for chronic efficacy studies led to the discovery of (S)-2-{[3'-(4-chloro-2,5-dimethylphenylsulfonylamino)-3,5-dimethylbiphenyl-4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2c76607f1881583858e4173829ead6
https://pubmed.ncbi.nlm.nih.gov/23067318
https://pubmed.ncbi.nlm.nih.gov/23067318
Publikováno v:
Cardiovascular Research. 28:215-220
Objective: Both calcium antagonists and angiotensin converting enzyme (ACE) inhibitors are known to diminish the development of intimal thickening after a balloon catheter lesion. It was previously shown that narrowing of carotid artery lumen induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6e7c74b64e62a559139677f451b0fe
https://doi.org/10.1093/cvr/28.2.215
https://doi.org/10.1093/cvr/28.2.215
Publikováno v:
Thrombosis and Haemostasis. 70:838-847
SummaryIn vitro platelet aggregation studies in whole blood were used to define the species-specificity profile of two synthetic GP-IIb/IIIa antagonists, Ro 43-8857 and L-700,462. Aggregation of rhesus monkey platelets was inhibited with a similar po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a24a47b6c50f8125c921f72079d479
https://doi.org/10.1055/s-0038-1649680
https://doi.org/10.1055/s-0038-1649680
Autor:
Gisbert, Weckbecker, Charles, Pally, Christian, Beerli, Christoph, Burkhart, Grazyna, Wieczorek, Barbara, Metzler, Randall E, Morris, Juergen, Wagner, Christian, Bruns
Publikováno v:
Transplant international : official journal of the European Society for Organ Transplantation. 23(5)
NVP-AEB071 (AEB, sotrastaurin), an oral inhibitor of protein kinase C (PKC), effectively blocks T-cell activation. The immunosuppressive effects of oral AEB were demonstrated in a rat local graft versus host (GvH) reaction and rat cardiac transplanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd1d44b1c016df7b43c7da7c87c00ada
https://pubmed.ncbi.nlm.nih.gov/20003043
https://pubmed.ncbi.nlm.nih.gov/20003043