Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Charles P. Rock"'
Autor:
Christopher D. Radka, Matthew W. Frank, Tyler S. Simmons, Cydney N. Johnson, Jason W. Rosch, Charles O. Rock
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Commensal gut bacteria use oleate hydratase to release a spectrum of hydroxylated fatty acids using host-derived unsaturated fatty acids. These compounds are thought to attenuate the immune response, but the underlying signaling mechanism(s) remain t
Externí odkaz:
https://doaj.org/article/70f3502acdec48fe9505c1796b4179e0
Autor:
Dmitry Leshchiner, Federico Rosconi, Bharathi Sundaresh, Emily Rudmann, Luisa Maria Nieto Ramirez, Andrew T. Nishimoto, Stephen J. Wood, Bimal Jana, Noemí Buján, Kaicheng Li, Jianmin Gao, Matthew Frank, Stephanie M. Reeve, Richard E. Lee, Charles O. Rock, Jason W. Rosch, Tim van Opijnen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A lack of understanding in the development and emergence of antimicrobial resistance presents as a problem for accurate infection diagnosis and treatment. Here, authors utilize Streptococcus pneumoniae and build a genome-wide atlas to understand the
Externí odkaz:
https://doaj.org/article/79f7f04a405b4d6d8aab8145e4e451c5
Autor:
Yanan Li, Jeffrey Steinberg, Zane Coleman, Shubo Wang, Chitra Subramanian, Yimei Li, Zoltan Patay, Walter Akers, Charles O. Rock, Suzanne Jackowski, Puneet Bagga
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-7 (2022)
Abstract Background Pantothenate kinase (PANK) is the first and rate-controlling enzymatic step in the only pathway for cellular coenzyme A (CoA) biosynthesis. PANK-associated neurodegeneration (PKAN), formerly known as Hallervorden–Spatz disease,
Externí odkaz:
https://doaj.org/article/f471643e687d4de7b4380850486b58d0
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Phosphatidylglycerol (PG) is the major membrane phospholipid of Staphylococcus aureus and predominately consists of molecular species with ≥16-carbon acyl chains in the 1-position and anteiso 12(S)-methyltetradecaonate (a15) esterified at
Externí odkaz:
https://doaj.org/article/cf3a8033dac5423f97d3bcf2bd7e73c2
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT Staphylococcus aureus is an important pathogen that relies on a variety of mechanisms to evade and counteract the immune system. We show that S. aureus uses oleate hydratase (OhyA) to convert host cis-9 unsaturated fatty acids to their 10-hy
Externí odkaz:
https://doaj.org/article/47fea363acfc4c50b4eb4236ec194815
Autor:
Surya D. Aggarwal, Jessica M. Gullett, Tara Fedder, J. Pedro F. Safi, Charles O. Rock, N. Luisa Hiller
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
Adaptation of bacteria to their host environment is a key component of colonization and pathogenesis. As an essential component of bacterial membranes, fatty acid composition contributes to host adaptation.
Externí odkaz:
https://doaj.org/article/dc72b3001b8c4992b928d5199381fe64
Autor:
Matthew W. Frank, Jiangwei Yao, Justin L. Batte, Jessica M. Gullett, Chitra Subramanian, Jason W. Rosch, Charles O. Rock
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Staphylococcus aureus utilizes the fatty acid (FA) kinase system to activate exogenous FAs for membrane synthesis. We developed a lipidomics workflow to determine the membrane phosphatidylglycerol (PG) molecular species synthesized by S. aur
Externí odkaz:
https://doaj.org/article/c0ca964bc43b49d1a868f31ece6173e2
Autor:
Lalit Kumar Sharma, Chitra Subramanian, Mi-Kyung Yun, Matthew W. Frank, Stephen W. White, Charles O. Rock, Richard E. Lee, Suzanne Jackowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Mutations in pantotenate kinase (PANK) cause neurodegneration. Here the authors carry out achemical screen and identify a PANK activator that is orally available, crosses the blood brain barrierand show that it effecttive in improving pathology and l
Externí odkaz:
https://doaj.org/article/df56f7ef021a4881aab28f7777533ce7
Autor:
Angela M. Arensdorf, Miriam E. Dillard, Jacob M. Menke, Matthew W. Frank, Charles O. Rock, Stacey K. Ogden
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2074-2087 (2017)
The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and -independent routes, with G protein-independent canonical signaling to Gli effectors requiring S
Externí odkaz:
https://doaj.org/article/b86b6f142827478da70fd3082ded0c9a
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT During infection, bacteria use two-component signal transduction systems to sense and adapt to the dynamic host environment. Despite critically contributing to infection, the activating signals of most of these regulators remain unknown. Thi
Externí odkaz:
https://doaj.org/article/e666c8f652c7408898634f1b3a3ecbfb