Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Charles P. Fulco"'
Autor:
John P. Ray, Carl G. de Boer, Charles P. Fulco, Caleb A. Lareau, Masahiro Kanai, Jacob C. Ulirsch, Ryan Tewhey, Leif S. Ludwig, Steven K. Reilly, Drew T. Bergman, Jesse M. Engreitz, Robbyn Issner, Hilary K. Finucane, Eric S. Lander, Aviv Regev, Nir Hacohen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP
Externí odkaz:
https://doaj.org/article/1ebe14a757924ee7b684604e682e0db0
Autor:
Beth A. Beidleman, Charles S. Fulco, Allen Cymerman, Janet E. Staab, Mark J. Buller, Stephen R. Muza
Publikováno v:
Physiological Reports, Vol 7, Iss 20, Pp n/a-n/a (2019)
Abstract Medical personnel need practical guidelines on how to construct high altitude ascents to induce altitude acclimatization and avoid acute mountain sickness (AMS) following the first night of sleep at high altitude. Using multiple logistic reg
Externí odkaz:
https://doaj.org/article/c0277a44cb7645c09ff35d8ca50c2258
Autor:
Steven Gazal, Omer Weissbrod, Farhad Hormozdiari, Kushal K. Dey, Joseph Nasser, Karthik A. Jagadeesh, Daniel J. Weiner, Huwenbo Shi, Charles P. Fulco, Luke J. O’Connor, Bogdan Pasaniuc, Jesse M. Engreitz, Alkes L. Price
Publikováno v:
Nature genetics, vol 54, iss 6
Nat Genet
Nat Genet
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking strategies have been developed to link regulatory SNPs to the genes that they regul
Autor:
Mahshid Rahmat, Kendell Clement, Jean-Baptiste Alberge, Romanos Sklavenitis-Pistofidis, Rohan Kodgule, Charles P. Fulco, Daniel Heilpern-Mallory, Katarina Nilsson, David Dorfman, Jesse M. Engreitz, Gad Getz, Luca Pinello, Russell Ryan, Irene M. Ghobrial
MYCderegulation occurs in 67% of multiple myeloma (MM) cases and associates with progression and worse prognosis in MM. EnhancedMYCexpression is known to be driven by translocation or amplification events, but it only occurs in 40% of MM patients. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a3b3530c29aca2b6824a27eb28cc23b
https://doi.org/10.1101/2023.05.19.541506
https://doi.org/10.1101/2023.05.19.541506
Autor:
Ashwin R. Iyer, Aishwarya Gurumurthy, Rohan Kodgule, Athalee R. Aguilar, Travis Saari, Abdullah Ramzan, Dylan Rausch, Juhi Gupta, Cody N. Hall, John S. Runge, Matthew Weiss, Mahshid Rahmat, Rockwell Anyoha, Charles P. Fulco, Irene M. Ghobrial, Jesse Engreitz, Marcin P. Cieslik, Russell J.H. Ryan
Publikováno v:
bioRxiv
High expression ofMYCand its target genes define a subset of germinal center B-cell diffuse large B-cell lymphoma (GCB-DLBCL) associated with poor outcomes. Half of these high-grade cases show chromosomal rearrangements between theMYClocus and hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ac2fa950f60ae4ea709ef5d5410fb
https://doi.org/10.1101/2023.05.02.538892
https://doi.org/10.1101/2023.05.02.538892
Autor:
Johanna Dahlqvist, Charles P Fulco, John P Ray, Thomas Liechti, Carl G de Boer, David J Lieb, Thomas M Eisenhaure, Jesse M Engreitz, Mario Roederer, Nir Hacohen
Publikováno v:
Hum Mol Genet
Background: FCGR2A binds antibody–antigen complexes to regulate the abundance of circulating and deposited complexes along with downstream immune and autoimmune responses. Although the abundance of FCRG2A may be critical in immune-mediated diseases
Autor:
Brandon M. Cuevas, Katerina Politi, Bomiao Hu, Charles P. Fulco, Pratiksha I. Thakore, Michael S. Cuoco, Jan-Christian Hütter, William Colgan, Aaron N. Hata, Sara A. Hurvitz, Kerry A. Pierce, Amy Deik, Liat Amir-Zilberstein, Marcin Tabaka, Joan S. Brugge, Dennis J. Slamon, Aviv Regev, Galit Lahav, Michael Tsabar, Clary B. Clish, Yaara Oren, Elma Zaganjor, Heidie Frisco Cabanos
Publikováno v:
Nature, vol 596, iss 7873
Nature
Nature
Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure1, where some cancer cells can enter a reversible drug-tolerant persister state in response to treatment2. Although most cancer persisters remain arrested in t
Autor:
Drew T. Bergman, Thouis R. Jones, Vincent Liu, Judhajeet Ray, Evelyn Jagoda, Layla Siraj, Helen Y. Kang, Joseph Nasser, Michael Kane, Antonio Rios, Tung H. Nguyen, Sharon R. Grossman, Charles P. Fulco, Eric S. Lander, Jesse M. Engreitz
Publikováno v:
Nature
Gene regulation in the human genome is controlled by distal enhancers that activate specific nearby promoters(1). One model for this specificity is that promoters might have sequence-encoded preferences for certain enhancers, for example mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb3d3baa45e039ae2417a5316045a5d
https://europepmc.org/articles/PMC9262863/
https://europepmc.org/articles/PMC9262863/
Autor:
Drew T. Bergman, Philine Guckelberger, Eric S. Lander, Jesse M. Engreitz, Qingbo Wang, Vidya Subramanian, Anna Greka, Linlin M. Chen, Benjamin R. Doughty, Joseph Nasser, Sarah Mangiameli, Jamie L. Marshall, Teia Noel, K. Zhang, Fei Chen, Charles P. Fulco, Elizabeth J. Grinkevich, Samuel G. Rodriques
Publikováno v:
Proc Natl Acad Sci U S A
Single-cell quantification of RNAs is important for understanding cellular heterogeneity and gene regulation, yet current approaches suffer from low sensitivity for individual transcripts, limiting their utility for many applications. Here we present
Autor:
Nir Hacohen, Caleb A. Lareau, Drew T. Bergman, Leif S. Ludwig, Masahiro Kanai, Robbyn Issner, John P. Ray, Steven K. Reilly, Eric S. Lander, Jesse M. Engreitz, Carl G. de Boer, Ryan Tewhey, Jacob C. Ulirsch, Charles P. Fulco, Aviv Regev, Hilary K. Finucane
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Genome-wide association studies have associated thousands of genetic variants with complex traits and diseases, but pinpointing the causal variant(s) among those in tight linkage disequilibrium with each associated variant remains a major challenge.