Výsledky vyhledávání - "Charles P, Lollo"

Comparative Pharmacokinetic Analysis of Community Use Naloxone formulations for Acute Treatment of Opioid Overdose

Autor: Charles P. Lollo, Dennis J. Carlo, Ronald B. Moss, Fiona Carleton

Publikováno v: Addiction Research and Adolescent Behaviour. 2:01-04

Recent increases in mortality from overdoses in the US have been primarily driven by deaths due to the more potent synthetic opioids. Naloxone is an effective countermeasure to treat opioid overdose. We compared the pharmacokinetics of the three avai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c86d32bebbf79c3c7b6bcf3f90e4e540
https://doi.org/10.31579/2688-7517/014

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An open-label, randomized, single-dose, two-period, two-treatment crossover bioavailability study comparing 5 mg/0.5 mL of intramuscular naloxone hydrochloride to 2 mg/0.4 mL intramuscular naloxone hydrochloride autoinjector in healthy subjects

Autor: Fiona Carleton, Ronald B. Moss, Dennis J. Carlo, Charles P. Lollo

Publikováno v: Journal of opioid management. 16(3)

Naloxone is an opioid antagonist used for the acute treatment of opioid overdoses. There has been a dramatic increase of deaths due to synthetic opioids such as fentanyl, some requiring multiple doses of naloxone for reversal of opioid toxicity. Fent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8cecd2c1bbc721c1ef384bf2fd745c
https://pubmed.ncbi.nlm.nih.gov/32421841

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Development and validation of a liquid chromatography method for simultaneous determination of three process-related impurities: yeastolates, triton X-100 and methotrexate

Autor: Shiping Fang, Michael J. LaBarre, Celine Derunes, Charles P. Lollo

Publikováno v: Journal of Chromatography B. 879:3612-3619

Yeastolates, triton X-100 (TX-100) and methotrexate (MTX) are common process-related impurities (PRI) in cell-based bioproduction of many active biopharmaceuticals. In this study, a reverse phase high performance liquid chromatography (RP-HPLC) metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca21b7bf204bc37e11825cca4e95024
https://doi.org/10.1016/j.jchromb.2011.10.003

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Strength of conjugate binding to plasmid DNA affects degradation rate and expression level in vivo

Autor: Arjang Amini, Joanne M Fabrycki, Quynh-Chi Phan, Dennis J. Carlo, Patrick Pezzoli, Christopher C. Coffin, Charles P. Lollo, Mariusz G. Banaszczyk, Patricia M. Mullen, Alison T. Carlo, Dongpei Wu

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1523:103-110

In vitro assays have demonstrated the capability of poly- L -lysine to protect plasmid DNA from serum nucleases and cellular lysates. Our purpose was to evaluate the stability and potency of poly- L -lysine–DNA polyplexes after intravenous injectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7423933a12692cdb3c26bab3c6e942
https://doi.org/10.1016/s0304-4165(00)00104-5

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POLY-L-LYSINE-GRAFT-PEG COMB-TYPE POLYCATION COPOLYMERS FOR GENE DELIVERY

Autor: Mariusz G. Banaszczyk, Charles P. Lollo, Patricia M. Mullen, Steven W. Brostoff, Alison T. Phillips, Arjang Amini, Christopher C. Coffin, Duncan P. Wu, Deborah Y. Kwoh, Dennis J. Carlo

Publikováno v: Journal of Macromolecular Science, Part A. 36:1061-1084

Polycations have been used for gene delivery in vitro quite successfully, however, in vivo applications suffered from serum effects that lower the overall gene drug efficiency. PEG polymers have been used extensively to minimize serum effects and cre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00c59ba433b2b6a965a17392d4679882
https://doi.org/10.1080/10601329908951200

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Stabilization of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver

Autor: Richard M. Bartholomew, Alison T. Phillips, Christopher C. Coffin, Charles P. Lollo, Steven W. Brostoff, Mariusz G. Banaszczyk, Dennis J. Carlo, Jocelyn Jovenal, Patricia M. Mullen, Deborah Y. Kwoh, Arjang Amini, Joanne M Fabrycki

Publikováno v: Biochimica et biophysica acta. 1444(2)

We are developing a self-assembling non-viral in vivo gene delivery vehicle based on poly-l-lysine and plasmid DNA. We have characterized poly-l-lysines of different chain lengths for DNA condensation and strength of DNA binding. Poly-l-lysine chains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcb161793fe1f9e1b38aaf237174e01
https://pubmed.ncbi.nlm.nih.gov/10023051

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DNA condensation for gene therapy as monitored by atomic force microscopy

Autor: Helen G. Hansma, Charles P. Lollo, Deborah Kwoh, Roxana Golan, Wan Hsieh, Patricia Mullen-Ley

The atomic force microscope (AFM) was used to assay the extent of DNA condensation in approximately 100 different complexes of DNA with polylysine (PL) or PL covalently attached to the glycoproteins asialoorosomucoid (AsOR) or orosomucoid (OR). The b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb45550922a828522b8f074f7aa702cf
https://europepmc.org/articles/PMC147577/

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