Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Charles O. Watlington"'
Publikováno v:
American Journal of Physiology-Cell Physiology. 274:C1245-C1252
We have confirmed that A6 cells (derived from kidney of Xenopus laevis), which contain both mineralocorticoid and glucocorticoid receptors, do not normally possess 11β-hydroxysteroid dehydroxgenase (11β-HSD1 or 11β-HSD2) enzymatic activity and so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3115a6dd4b59a5ec269ee6b7a6dc53e
https://doi.org/10.1152/ajpcell.1998.274.5.c1245
https://doi.org/10.1152/ajpcell.1998.274.5.c1245
Autor:
S Ghosh, Charles O. Watlington, Walter E. Nance, L. B. Kramer, Rodney D. Hagley, Ashish K. Basu
Publikováno v:
American Journal of Hypertension. 8:321-324
Relationship between family-3A cytochrome P-450-dependent (troleandomycin inhibitable) and maternal environmental-dependent systolic blood pressure (SBP) was investigated in spontaneously hypertensive rats (SHR). Adult SHR nursed by foster or natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba7e81263639130b6001753bad07b22
https://doi.org/10.1016/0895-7061(94)00198-k
https://doi.org/10.1016/0895-7061(94)00198-k
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1182:152-156
Excess 6 beta-OH-corticosterone production by family 3A cytochromes P-450 may play a role in genesis of hypertension in the spontaneously hypertensive rat (SHR), by producing a renal defect in Na+ excretion. Renal cytochromes P-450 may be a causal fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b627f3c6cad2fb85875612300e0bd70a
https://doi.org/10.1016/0925-4439(93)90136-o
https://doi.org/10.1016/0925-4439(93)90136-o
Publikováno v:
Kidney International. 42(6):1297-1308
(1) Decreased 11 beta-OHSD activity permits binding of cortisol to the Type I (mineralocorticoid) receptor in humans, thereby producing spironolactone-inhibitable Na+ retention, hypokalemia and hypertension, the syndrome of apparent mineralocorticoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe1486706e3f2aa389ceb2b7965a0ac
Publikováno v:
Endocrinology. 129:17-21
Aldosterone selectivity in mineralocorticoid target tissues has been suggested to be due to 11β-hydroxysteroid dehydrogenase (11-OHSD), which, by inactivating the endogenous glucocorticoids cortisol and corticosterone (CS), would allow aldosterone t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72442578f62c56a8ab53482e6f7bdfe2
https://doi.org/10.1210/endo-129-1-17
https://doi.org/10.1210/endo-129-1-17
Autor:
David J. Morris, Charles O. Watlington, Tammy J. Conca, Syed A. Latif, Cedric H.L. Shackleton, David N. Kirk, Liente Wei, Harold Toms
Publikováno v:
Steroids. 55:482-486
Incubation of aldoslerone with confluent layers of A6 (toad kidney) cells leads to its hydroxylation at the 6β-position. 6β-Hydroxyaldosterone is the major metabolite when the incubation is carried out at pH 6.8, whereas the product comprises dβ-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7e8f48c6418b908a2c13a156f9da15
https://doi.org/10.1016/0039-128x(90)90084-o
https://doi.org/10.1016/0039-128x(90)90084-o
Publikováno v:
American Journal of Physiology-Cell Physiology. 258:C480-C488
We found microsomal corticosterone 6 beta-hydroxylase (6 beta-OHase) from cultured A6 kidney epithelial cells to be a cytochrome P-450 enzyme with both similarities to and differences from the rat liver steroid 6 beta-OHase P-450p. Enzyme activity wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974225597549d2e8d46cf2a89b599989
https://doi.org/10.1152/ajpcell.1990.258.3.c480
https://doi.org/10.1152/ajpcell.1990.258.3.c480
Publikováno v:
Annals of the New York Academy of Sciences. 761:405-407
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d092b96261e747dbd31867b0c4279c39
https://doi.org/10.1111/j.1749-6632.1995.tb31404.x
https://doi.org/10.1111/j.1749-6632.1995.tb31404.x
Autor:
Charles O. Watlington
Publikováno v:
The American journal of physiology. 274(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74a46e6daf5e65512656bca16e35971
https://pubmed.ncbi.nlm.nih.gov/9458711
https://pubmed.ncbi.nlm.nih.gov/9458711
Publikováno v:
Endocrine research. 22(3)
The A6 cell line, derived from Xenopus kidney, is an in vitro model of cortico-steroid mediated transepitheial Na+ transport stimulation. We report the apparent down-regulation of mineralocorticoid receptor levels in A6 cells, in response to the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7088281697f951d7fdd614864ce428d2
https://pubmed.ncbi.nlm.nih.gov/8875136
https://pubmed.ncbi.nlm.nih.gov/8875136