Výsledky vyhledávání - "Charles O. Ochieng"

Akademický článek

Inhibition Kinetics and Theoretical Studies on Zanthoxylum chalybeum Engl. Dual Inhibitors of α-Glucosidase and α-Amylase

Autor: Njogu M. Kimani, Charles O. Ochieng, Mike Don Ogutu, Kevin Otieno Yamo, Joab Otieno Onyango, Cleydson B. R. Santos

Publikováno v: Journal of Xenobiotics, Vol 13, Iss 1, Pp 102-120 (2023)

Compounds from Zanthoxylum chalybeum Engl. were previously reported for inhibitory activities of amylase and glucosidase enzymatic action on starch as a preliminary study toward the establishment of a management strategy against postprandial hypergly

Externí odkaz: https://doaj.org/article/ccf770dd614c4b919b3eff6bd054bedf

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Monoaminergic system involvement in the antidepressant-like and anxiolytic-like properties of novel β-dihydroagarofuran sesquiterpene alkaloid and triterpenes isolated from Gymnosporia heterophylla aerial parts in mice

Autor: Ismail O. Ishola, Taiwo G. Olubodun-Obadun, Charles O. Ochieng, Mary C. Nwajuwe, Reign-el U. Mukoro, Olufunmilayo O. Adeyemi

Publikováno v: Neurochemistry International. 158:105379

Gymnosporia heterophylla (synonym Maytenus) is widely used in folk medicine for the treatment of various illness including neurological diseases. This study presents the antidepressant-like and anxiolytic-like effects of novel bioactive constituents;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c58035f678a9d037b4b3f308ff1448
https://doi.org/10.1016/j.neuint.2022.105379

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α-Amylase and α-glucosidase inhibitors from Zanthoxylum chalybeum Engl. root bark

Autor: Charles O. Ochieng, Moses K. Langat, Daniel W. Nyongesa, Kevin O. Yamo, Lawrence A.O. Manguro, Joab O. Onyango

Publikováno v: Fitoterapia. 146

A systematic analysis of the root bark of Zanthoxylum chalybeum was conducted to establish the antidiabetic potential of isolated compounds based on its ethnomedicinal use to manage diabetes. Chromatographic separation of alkaloid extracts led to iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e8b4741232f0055b374f80a35a9f78
https://pubmed.ncbi.nlm.nih.gov/32889048

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Cyclooxygenase inhibitory compounds from Gymnosporia heterophylla aerial parts

Autor: Charles O. Ochieng, Ismail O. Ishola, Edward W. Mureka, Sylvia A. Opiyo

Publikováno v: Fitoterapia. 119

Gymnosporia heterophylla (Celastraceae) is an African medicinal plants used to treat painful and inflammatory diseases with partial scientific validation. Solvent extractions followed by repeated chromatographic purification of the G. heterophylla ae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2453d247ef2e604d838d5af5aab8982d
https://pubmed.ncbi.nlm.nih.gov/28476411

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Effects of Senna didymobotrya Root Extract and Compounds on Tritoninduced Hyperlipidaemic Rats and Differentiation of 3T3-Li Preadipocytes

Autor: Lawrence Onyango Arot Manguro, Ravi Sonkar, Gitika Bhatia, Rakesh K. Asthana, Ashok Kumar Khanna, Anil K. Saxena, Charles O. Ochieng, Atul Shrivastava, Upma Chaturvedi, Philip O. Owuor

Publikováno v: The Natural Products Journal. 3:212-217

The lipid lowering effects of Senna didymobotrya (Leguminoceae) root extract (250 mg/kg) and pure isolates (100 mg/kg) were investigated for hypolipidemic activity on Triton-induced hyperlipidemic rats (in-vivo). The extracts and isolates showed sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c863dd5f2e093d45db6f5c621049c62
https://doi.org/10.2174/22103155113039990011

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Isolation of a new β-carboline alkaloid from aerial parts of Triclisia sacleuxii and its antibacterial and cytotoxicity effects

Autor: Jacob O. Midiwo, Philip O. Owuor, Charles O. Ochieng, Lawrence Onyango Arot Manguro, Fidelis Samita

Publikováno v: Natural product research. 31(5)

A new β-carboline alkaloid named sacleuximine A (1) together with known compounds palmatine (2), isotetrandrine (3), trans-N-feruloyltyramine (4), trans-N-caffeoyltyramine (5), yangambin (6), syringaresinol (7), sesamin (8), (+) epi-quercitol (9), 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844bc54bd512fc7d4d48281e861d1042
https://pubmed.ncbi.nlm.nih.gov/27373319

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Antinociceptive and antiplasmodial activities of cassane furanoditerpenes from Caesalpinia volkensii H. root bark

Autor: P. Okinda Owuor, Hosea Akala, Charles O. Ochieng, Ismail O. Ishola, Lawrence A.O. Manguro

Publikováno v: Fitoterapia. 83:74-80

The chloroform and ethyl acetate extract (100 mg/kg) of Caesalpinia volkensii H. exhibited significant (P ≤ 0.05) antinociceptive activities using hot plate and writhing tests in mice while the later showed antiplasmodial activity (IC50 0.23 ± 0.0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c3bb2ab638633c77fad8acd19db8db
https://doi.org/10.1016/j.fitote.2011.09.015

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