Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Charles O Noble"'
Autor:
Dmitri B. Kirpotin, Mark E. Hayes, Charles O. Noble, Zhaohua Richard Huang, Kshitija Wani, Doug Moore, Kevin Kesper, Drew O’ Brien, Daryl C. Drummond
Publikováno v:
Journal of Pharmaceutical Sciences. 112:416-434
Therapeutics at or close to the nanoscale, such as liposomal irinotecan, offer significant promise for the treatment of solid tumors. Their potential advantage over the unencapsulated or free form of the drug is due in part to their altered biodistri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bd9f760d124dc003eb2aa686d5244c
https://doi.org/10.1016/j.xphs.2022.11.025
https://doi.org/10.1016/j.xphs.2022.11.025
Publikováno v:
Blood. 140:11557-11558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b23686365a13fe25568c4ba78721103
https://doi.org/10.1182/blood-2022-168103
https://doi.org/10.1182/blood-2022-168103
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8e94f819de7e7f6ccdf49b01d0fee2
https://doi.org/10.1038/s41551-019-0385-4
https://doi.org/10.1038/s41551-019-0385-4
Autor:
Suresh K. Tipparaju, Charles O. Noble, Alexander Koshkaryev, Walid S. Kamoun, Jimmy Tran, Tad Kornaga, Daryl C. Drummond, Zhaohua Richard Huang, Christine Pien, Dmitri B. Kirpotin
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 310
Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8518d6c9b5dbb65c54db1d72e289f2ed
https://pubmed.ncbi.nlm.nih.gov/31400383
https://pubmed.ncbi.nlm.nih.gov/31400383
Autor:
Ran Ming, Nan Zheng, Charles O. Noble, Zhipeng Dai, Yayuan Liu, Wenmin Yuan, Anna Schwendeman, Jie Tang, Wenlei Jiang, Santhanakrishnan Srinivasan, Francis C. Szoka, Mark E. Hayes
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 134
AmBisome® is a liposomal formulation of amphotericin B (Amp B), a complex parenteral antifungal product with no US FDA approved generic version available to date. For generic Amp B liposomal product development, examination of the drug release profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300778ffcb3b43748ad215e56e27fb1b
https://pubmed.ncbi.nlm.nih.gov/30481559
https://pubmed.ncbi.nlm.nih.gov/30481559
Autor:
Charles David James, Charles O. Noble, Lucy X Chao, Anne M Kuwabara, Kevin C. Weng, Fanqing F. Chen, Dmitri B. Kirpotin, Rintaro Hashizume, Daryl C. Drummond, John W. Park, Laura Serwer
Publikováno v:
Nanomedicine. 8:1913-1925
Aim: The aim of this work is to evaluate combining targeting strategy and convection-enhanced delivery in brain tumor models by imaging quantum dot–immunoliposome hybrid nanoparticles. Materials & methods: An EGF receptor-targeted, quantum dot–im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd7f3ef57f12de70c1242f583f02ab0
https://doi.org/10.2217/nnm.12.209
https://doi.org/10.2217/nnm.12.209
Autor:
Jane Rabbitt, Annette M. Molinaro, Jennie Taylor, Juan R. Cabrera, Charles O. Noble, Jaeyeon Kim, Joshua Prey, Jonathan Fitzgerald, Ashley A. DeSilva, Nicholas Butowski, John W. Park, Susan M. Chang, Michael D. Prados, Daryl C. Drummond, Jennifer Clarke
Publikováno v:
Cancer chemotherapy and pharmacology. 79(3)
Preclinical activity of irinotecan has been seen in glioma models, but only modest efficacy has been noted in clinical studies, perhaps related to drug distribution and/or pharmacokinetic limitations. In preclinical testing, irinotecan liposome injec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08ea6e71383b0d8b98efa4cd888579e
https://pubmed.ncbi.nlm.nih.gov/28233053
https://pubmed.ncbi.nlm.nih.gov/28233053
Autor:
Bart S. Hendriks, Thomas Wickham, Samuel V. Agresta, Helen Lee, Elena Geretti, Clet Niyikiza, Stephan G. Klinz, Petra B. Lücker, Peter W. Zandstra, Shannon C. Leonard, Daryl C. Drummond, Joseph G. Reynolds, Ulrik B. Nielsen, Charles O. Noble, Kenneth J. Olivier
Publikováno v:
Toxicology and Applied Pharmacology. 262:1-10
Anthracycline-based regimens are a mainstay of early breast cancer therapy, however their use is limited by cardiac toxicity. The potential for cardiotoxicity is a major consideration in the design and development of combinatorial therapies incorpora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383e69192e693fd9989d11f09b21fab6
https://doi.org/10.1016/j.taap.2012.04.008
https://doi.org/10.1016/j.taap.2012.04.008
Autor:
Charles O. Noble, Tomoko Ozawa, John W. Park, C. David James, Michael D. Prados, Laura Serwer, Dmitri B. Kirpotin, Karine Michaud, Daryl C. Drummond
Publikováno v:
Neuro-Oncology. 13:1288-1295
Achieving effective treatment outcomes for patients with glioblastoma (GBM) has been impeded by many obstacles, including the pharmacokinetic limitations of antitumor agents, such as topotecan (TPT). Here, we demonstrate that intravenous administrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a136ed132a79bcb14761111cf2c3695
https://doi.org/10.1093/neuonc/nor139
https://doi.org/10.1093/neuonc/nor139
Autor:
Michal T. Krauze, Yoji Yamashita, Richard A Lecouteur, Robert Higgins, John Bringas, John W. Park, Daryl C. Drummond, Mitchel S. Berger, Dmitri B. Kirpotin, Krystof S. Bankiewicz, Richard F. Larson, John Forsayeth, Charles O. Noble, Peter J Dickinson
Publikováno v:
Neuro-Oncology. 12:928-940
Canine spontaneous intracranial tumors bear striking similarities to their human tumor counterparts and have the potential to provide a large animal model system for more realistic validation of novel therapies typically developed in small rodent mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfd96dc03423422144df8ebd871c079
https://doi.org/10.1093/neuonc/noq046
https://doi.org/10.1093/neuonc/noq046