Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Charles O Elson"'
Autor:
Zdenek Hel, Jun Xu, Warren L Denning, E Scott Helton, Richard P H Huijbregts, Sonya L Heath, E Turner Overton, Benjamin S Christmann, Charles O Elson, Paul A Goepfert, Jiri Mestecky
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006087 (2017)
HIV-1 infection is associated with an early and profound depletion of mucosal memory CD4+ T cells, a population that plays an indispensable role in the regulation of isotype switching and transepithelial transport of antibodies. In this study, we add
Externí odkaz:
https://doaj.org/article/8743f1f8deb14ed98c593648f7ae4bbb
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181866 (2017)
Cultivating an environment of mutualism between host cells and the microbiota is vital, and dysregulation of this relationship is associated with multiple immune disorders including metabolic and skin diseases, asthma, allergy, and Inflammatory Bowel
Externí odkaz:
https://doaj.org/article/8059c103be77425fa14c66d2a04a4e2b
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150943 (2016)
Over the past decade, emerging evidence has linked alterations in the gut microbial composition to a wide range of diseases including obesity, type 2 diabetes, and cardiovascular disease. Toll-like receptors (TLRs) are the major mediators for the int
Externí odkaz:
https://doaj.org/article/b41b0dc18be74225b031d46203c1fa17
Autor:
Charles O Elson, Robert P Mccabe, Kenneth W Beagley, Almaz Sharmanov, Steven L Brandwein, Ben U Ridwan, Casey Weaver, R Patrick Bucy, Jerry R Mcghee, John Sundberg, Edward Birkenmeier
Publikováno v:
Canadian Journal of Gastroenterology, Vol 10, Iss 2, Pp 105-109 (1996)
Although the etiology of inflammatory bowel disease (IBD) remains unknown, a major working hypothesis is that it represents a dysregulated immune response to common enteric bacterial antigens. Until recently there has been a relative dearth of experi
Externí odkaz:
https://doaj.org/article/72d319328af041cc9bbf7d555e7e4f62
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35918 (2012)
Toll-like receptor (TLR) 5 has been shown to maintain intestinal homeostasis and regulate host defense against enterobacterial infection. However, how TLR5 expression is regulated and its function in the intestine have not been fully elucidated. Here
Externí odkaz:
https://doaj.org/article/db9d499c76c347a493286bf5366d3fa9
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Johannes F. Scheid, Basak Eraslan, Andrew Hudak, Eric M. Brown, Dallis Sergio, Toni M. Delorey, Devan Phillips, Ariel Lefkovith, Alison T. Jess, Lennard W. Duck, Charles O. Elson, Hera Vlamakis, Damian R. Plichta, Jacques Deguine, Ashwin N. Ananthakrishnan, Daniel B. Graham, Aviv Regev, Ramnik J. Xavier
Publikováno v:
Journal of Experimental Medicine. 220
Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in UC pathogenesis is unknown. We
Autor:
Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O’Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suárez-Fariñas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru
Publikováno v:
Nat Med
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n =
Autor:
Charles O, Elson
Publikováno v:
Gut. 72(1)
Autor:
Nadine N Morgan, Lennard W Duck, Jiongru Wu, Mahmud Rujani, Paul G Thomes, Charles O Elson, Peter J Mannon
Publikováno v:
Inflammatory bowel diseases. 28(12)
Background Specific microbial antigens stimulate production of antibodies indicative of the aberrant immune response in Crohn’s disease (CD). We tested for T cell reactivity linkage to B cell responses and now report on the prevalence, functionalit