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pro vyhledávání: '"Charles O, Elson"'
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Autor:
Johannes F. Scheid, Basak Eraslan, Andrew Hudak, Eric M. Brown, Dallis Sergio, Toni M. Delorey, Devan Phillips, Ariel Lefkovith, Alison T. Jess, Lennard W. Duck, Charles O. Elson, Hera Vlamakis, Damian R. Plichta, Jacques Deguine, Ashwin N. Ananthakrishnan, Daniel B. Graham, Aviv Regev, Ramnik J. Xavier
Publikováno v:
Journal of Experimental Medicine. 220
Plasma cells (PCs) constitute a significant fraction of colonic mucosal cells and contribute to inflammatory infiltrates in ulcerative colitis (UC). While gut PCs secrete bacteria-targeting IgA antibodies, their role in UC pathogenesis is unknown. We
Autor:
Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O’Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suárez-Fariñas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru
Publikováno v:
Nat Med
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n =
Autor:
Katie Alexander, Charles O. Elson
Publikováno v:
F1000Research, Vol 6 (2017)
Bacteria and mammals have co-evolved with one another over millennia, and it has become impossible to interpret mucosal immunity without taking the microbiota into consideration. In fact, the primary role of the mucosal immune system is regulating ho
Externí odkaz:
https://doaj.org/article/1bab2aab6b1f477b9e2155031f2ff2ca
Autor:
Zdenek Hel, Jun Xu, Warren L Denning, E Scott Helton, Richard P H Huijbregts, Sonya L Heath, E Turner Overton, Benjamin S Christmann, Charles O Elson, Paul A Goepfert, Jiri Mestecky
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006087 (2017)
HIV-1 infection is associated with an early and profound depletion of mucosal memory CD4+ T cells, a population that plays an indispensable role in the regulation of isotype switching and transepithelial transport of antibodies. In this study, we add
Externí odkaz:
https://doaj.org/article/8743f1f8deb14ed98c593648f7ae4bbb
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181866 (2017)
Cultivating an environment of mutualism between host cells and the microbiota is vital, and dysregulation of this relationship is associated with multiple immune disorders including metabolic and skin diseases, asthma, allergy, and Inflammatory Bowel
Externí odkaz:
https://doaj.org/article/8059c103be77425fa14c66d2a04a4e2b
Autor:
Charles O, Elson
Publikováno v:
Gut. 72(1)
Autor:
Nadine N Morgan, Lennard W Duck, Jiongru Wu, Mahmud Rujani, Paul G Thomes, Charles O Elson, Peter J Mannon
Publikováno v:
Inflammatory bowel diseases. 28(12)
Background Specific microbial antigens stimulate production of antibodies indicative of the aberrant immune response in Crohn’s disease (CD). We tested for T cell reactivity linkage to B cell responses and now report on the prevalence, functionalit
Autor:
Jeremy B. Foote, Hui-Chen Hsu, Trenton R. Schoeb, Charles O. Elson, David Ponder, Huixian Hong, John D. Mountz, Huma Fatima, Casey D. Morrow, Fatima Alduraibi, Wayne Duck
Publikováno v:
Arthritis Rheumatol
To determine the extent to which the gut microbiome influences systemic autoimmunity in a mouse model of lupus.We generated germ-free (GF) lupus-prone BXD2 mice, which under normal conditions develop spontaneous germinal centers (GCs) and high titers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2865e6bd4052915ff56a18dc87c9c983
https://europepmc.org/articles/PMC9071869/
https://europepmc.org/articles/PMC9071869/
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150943 (2016)
Over the past decade, emerging evidence has linked alterations in the gut microbial composition to a wide range of diseases including obesity, type 2 diabetes, and cardiovascular disease. Toll-like receptors (TLRs) are the major mediators for the int
Externí odkaz:
https://doaj.org/article/b41b0dc18be74225b031d46203c1fa17