Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Charles N. J. Ravarani"'
Autor:
Charles N. J. Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M. Madan Babu, Santhanam Balaji
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The TATA-box binding protein (TBP) is required for transcription initiation in archaea and eukaryotes. Here the authors delineate how TBP’s function has evolved new functional features through context-dependent interactions with various protein par
Externí odkaz:
https://doaj.org/article/04a4a2d60faa49f28d7ee8556002ba1a
Autor:
Justin L. Cope, Hannes A. Baukmann, Jörn E. Klinger, Charles N. J. Ravarani, Erwin P. Böttinger, Stefan Konigorski, Marco F. Schmidt
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Polygenic risk scores (PRS) aggregating results from genome-wide association studies are the state of the art in the prediction of susceptibility to complex traits or diseases, yet their predictive performance is limited for various reasons, not leas
Externí odkaz:
https://doaj.org/article/a1e9ca0dff42441b8518aca4ba8307bf
Autor:
Charles N. J. Ravarani, Guilhem Chalancon, Michal Breker, Natalia Sanchez de Groot, M. Madan Babu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
TATA boxes in gene promoters are associated with high level of cell-to-cell variation in gene expression. Through integration of multiple data sets, the authors now provide insights into how the interactions of TBP with DNA and other proteins can lea
Externí odkaz:
https://doaj.org/article/e3e7cf8d13c14af0856ae4db82ef2db9
Autor:
Marco F. Schmidt, Hannes A. Baukmann, Justin L. Cope, Charles N. J. Ravarani, Colin Bannard, Margaretha R. J. Lamparter, Alexander R. E. C. Schwinges, Joern E. Klinger
Despite the recent development of vaccines and monoclonal antibodies preventing SARS-CoV-2 infection, treating critically ill COVID-19 patients still remains a top goal. In principle, drug repurposing -- the use of an already existing drug for a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c986e2da72527634e756d3b10fce9a1
https://doi.org/10.21203/rs.3.rs-1469211/v1
https://doi.org/10.21203/rs.3.rs-1469211/v1
Autor:
Jörn Klinger, Marco F. Schmidt, Justin L. Cope, Erwin Boettinger, Hannes A. Baukmann, Stefan Konigorski, Charles N. J. Ravarani
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics, Vol 12 (2021)
Polygenic risk scores (PRS) aggregating results from genome-wide association studies are the state of the art in the prediction of susceptibility to complex traits or diseases, yet their predictive performance is limited for various reasons, not leas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d0e157f8dc18206c7dbe386b720009
https://doi.org/10.3389/fgene.2021.744557
https://doi.org/10.3389/fgene.2021.744557
Autor:
Joern E. Klinger, Colin Bannard, Hannes A. Baukmann, Alexander R. E. C. Schwinges, Justin L. Cope, Marco F. Schmidt, Margaretha R. J. Lamparter, Charles N. J. Ravarani
Despite the recent development of vaccines and monoclonal antibodies preventing SARS-CoV-2 infection, treating critically ill COVID-19 patients still remains a top goal. In principle, drug repurposing – the use of an already existing drug for a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7c73281bd3f882d754b4bd3c0001d97
https://doi.org/10.21203/rs.3.rs-568366/v1
https://doi.org/10.21203/rs.3.rs-568366/v1
Autor:
Hannes A. Baukmann, Justin L. Cope, Charles N. J. Ravarani, Colin Bannard, Margaretha R. J. Lamparter, Alexander R. E. C. Schwinges, Joern E. Klinger, Marco F. Schmidt
BackgroundDespite recent development of vaccines and monoclonal antibodies to prevent SARS-CoV-2 infection, treatment of critically ill COVID-19 patients remains an important goal. In principle, genome-wide association studies (GWAS) could shortcut t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e782cd079d452538111b75dd367cf8d
https://doi.org/10.1101/2021.05.18.21256584
https://doi.org/10.1101/2021.05.18.21256584
Autor:
Sreenivas Chavali, Madhanagopal Anandapadamanaban, Charles N. J. Ravarani, Tilman Flock, M. Madan Babu, S. Balaji
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Funder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265
TATA-box binding protein (TBP) is required for every single transcription event in archaea and eukaryotes. It binds DNA and harbors two repeats with an int
TATA-box binding protein (TBP) is required for every single transcription event in archaea and eukaryotes. It binds DNA and harbors two repeats with an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553cb7faf349fffd07bf42cd5666b2c1
http://europepmc.org/articles/PMC7221094
http://europepmc.org/articles/PMC7221094
Autor:
Melis Kayikci, Charles N. J. Ravarani, Tilman Flock, James Scott-Brown, AJ Venkatakrishnan, M. Madan Babu
Publikováno v:
Nature structural & molecular biology
Visualizations of biomolecular structures empower us to gain insights into biological functions, generate testable hypotheses, and communicate biological concepts. Typical visualizations (such as ball and stick) primarily depict covalent bonds. In co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dceafd24f903ab3192c3497ca98483
https://doi.org/10.1038/s41594-017-0019-z
https://doi.org/10.1038/s41594-017-0019-z
Autor:
Ala Trusina, Salvador Ventura, Charles N. J. Ravarani, Natalia Sanchez de Groot, M. Madan Babu, Marc Torrent Burgas
Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. What are the fitness costs and benefits of formi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec40e886e7a10a8e5eddf61ad3e484eb
https://doi.org/10.1101/574657
https://doi.org/10.1101/574657