Výsledky vyhledávání - "Charles Mullen"

Proton-detected solid-state NMR spectroscopy of natural-abundance peptide and protein pharmaceuticals

Autor: Dennis Sandoz, Gautam J. Shah, Chad M. Rienstra, Charles Mullen, Donghua H. Zhou

Publikováno v: Angewandte Chemie (International ed. in English). 48(7)

The natural way: A sensitive NMR spectroscopic method is developed to obtain well-resolved two-dimensional spectra ((15)N-(1)H and (13)C-(1)H) for natural-abundance (that is, without the need for isotopic enrichment) large-molecule samples, such as b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfd4b4406c10af737b3f12852da91ea
https://pubmed.ncbi.nlm.nih.gov/19130513

Zobrazit plný text záznamu

Proton-detected solid-state NMR spectroscopy of fully protonated proteins at 40 kHz magic-angle spinning

Autor: Charles Mullen, Chad M. Rienstra, Donghua H. Zhou, Gautam J. Shah, Mircea Cormos, Dennis Sandoz

Publikováno v: Journal of the American Chemical Society. 129(38)

Remarkable progress in solid-state NMR has enabled complete structure determination of uniformly labeled proteins in the size range of 5-10 kDa. Expanding these applications to larger or mass-limited systems requires further improvements in spectral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e6570120ac6cc5baf428cb3ef22e3f
https://pubmed.ncbi.nlm.nih.gov/17725352

Zobrazit plný text záznamu

Reduction of RF-induced sample heating with a scroll coil resonator structure for solid-state NMR probes

Autor: Chad M. Rienstra, Evan H. Williams, Sara A. Stellfox, Charles Mullen, Charles E. Bronnimann, Ying Li, Donghua H. Zhou, John A. Stringer

Publikováno v: Journal of magnetic resonance (San Diego, Calif. : 1997). 173(1)

Heating due to high power 1 H decoupling limits the experimental lifetime of protein samples for solid-state NMR (SSNMR). Sample deterioration can be minimized by lowering the experimental salt concentration, temperature or decoupling fields; however

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acda7ebabd60a5834f93e6a8dc5d2aaf
https://pubmed.ncbi.nlm.nih.gov/15705511

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání