Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Charles McSharry"'
Autor:
Lucy MacDonald, Stefano Alivernini, Barbara Tolusso, Aziza Elmesmari, Domenico Somma, Simone Perniola, Annamaria Paglionico, Luca Petricca, Silvia L. Bosello, Angelo Carfì, Michela Sali, Egidio Stigliano, Antonella Cingolani, Rita Murri, Vincenzo Arena, Massimo Fantoni, Massimo Antonelli, Francesco Landi, Francesco Franceschi, Maurizio Sanguinetti, Iain B. McInnes, Charles McSharry, Antonio Gasbarrini, Thomas D. Otto, Mariola Kurowska-Stolarska, Elisa Gremese
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic and resolving macrophage pathways and their role in COVID-19 pathogenesis. We found that bronchoalveolar lavage fluid (BALF) macrophage clusters FCN1+ and F
Externí odkaz:
https://doaj.org/article/f7b655b86d834a7192f3febd3b105516
Autor:
Hayley Barnes, Anna-Carin Olin, Kjell Torén, Charles McSharry, Iona Donnelly, Mona Lärstad, Carlos Iribarren, Patricia Quinlan, Paul D. Blanc
Publikováno v:
ERJ Open Research, Vol 6, Iss 4 (2020)
Background Despite well-documented case series of hypersensitivity pneumonitis (HP), epidemiological data delineating relative contributions of risk factors are sparse. To address this, we estimated HP risk in a case-referent study of occupational an
Externí odkaz:
https://doaj.org/article/fba53af67a1943149442222929bac43e
Autor:
Mariola Kurowska-Stolarska, Stefano Alivernini, Emma Garcia Melchor, Aziza Elmesmari, Barbara Tolusso, Clare Tange, Luca Petricca, Derek S. Gilchrist, Gabriele Di Sante, Chantal Keijzer, Lynn Stewart, Clara Di Mario, Vicky Morrison, James M. Brewer, Duncan Porter, Simon Milling, Ronald D. Baxter, David McCarey, Elisa Gremese, Greg Lemke, Gianfranco Ferraccioli, Charles McSharry, Iain B. McInnes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Axl is a TAM receptor that can inhibit Toll-like receptor (TLR) -induced pro-inflammatory production by dendritic cells (DC). Here the authors show that miR-34a targets Axl to control CD1c+ DC activity in mice, and that miR-34a-deficient mice are res
Externí odkaz:
https://doaj.org/article/82ffc64d997240fa87e18b12e513a829
Autor:
Tea Skaaby, Amy E. Taylor, Rikke K. Jacobsen, Lavinia Paternoster, Betina H. Thuesen, Tarunveer S. Ahluwalia, Sofus C. Larsen, Ang Zhou, Andrew Wong, Maiken E. Gabrielsen, Johan H. Bjørngaard, Claudia Flexeder, Satu Männistö, Rebecca Hardy, Diana Kuh, Sarah J. Barry, Line Tang Møllehave, Charlotte Cerqueira, Nele Friedrich, Tobias N. Bonten, Raymond Noordam, Dennis O. Mook-Kanamori, Christian Taube, Leon E. Jessen, Alex McConnachie, Naveed Sattar, Mark N. Upton, Charles McSharry, Klaus Bønnelykke, Hans Bisgaard, Holger Schulz, Konstantin Strauch, Thomas Meitinger, Annette Peters, Harald Grallert, Ellen A. Nohr, Mika Kivimaki, Meena Kumari, Uwe Völker, Matthias Nauck, Henry Völzke, Chris Power, Elina Hyppönen, Torben Hansen, Torben Jørgensen, Oluf Pedersen, Veikko Salomaa, Niels Grarup, Arnulf Langhammer, Pål R. Romundstad, Frank Skorpen, Jaakko Kaprio, Marcus R Munafò, Allan Linneberg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Observational studies on smoking and risk of hay fever and asthma have shown inconsistent results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses genetic variants as markers of
Externí odkaz:
https://doaj.org/article/86f8209da3f945428aa1227821d89acf
Autor:
Stefano Alivernini, Elisa Gremese, Charles McSharry, Barbara Tolusso, Gianfranco Ferraccioli, Iain B. McInnes, Mariola Kurowska-Stolarska
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. miR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immun
Externí odkaz:
https://doaj.org/article/bddc6fc3c13b47e3943570a2752c9ddb
Autor:
Stephen Bicknell, Rekha Chaudhuri, Nicola Lee, Malcolm Shepherd, Mark Spears, Nick Pitman, Euan Cameron, Douglas Cowan, Julie Nixon, Joyce Thompson, Charles McSharry, Neil C. Thomson
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 9 (2015)
Published information on the effectiveness of bronchial thermoplasty (BT) for severe asthma in ‘real life’ patients is limited. We compared safety and efficacy outcomes 12 months post procedure in 10 clinic patients and 15 patients recruited to c
Externí odkaz:
https://doaj.org/article/57d4168a7bd44d419e1d1ca36fb4f83e
Autor:
Mark Spears, Charles McSharry, Rekha Chaudhuri, Christopher J Weir, Carl de Wet, Neil C Thomson
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71460 (2013)
Current cigarette smoking is associated with reduced acute responses to corticosteroids and worse clinical outcomes in stable chronic asthma. The mechanism by which current smoking promotes this altered behavior is currently unclear. Whilst cytokines
Externí odkaz:
https://doaj.org/article/e2435ccb4b024242b2e969e4336aed00
Autor:
Charles McSharry, Megan K. L. MacLeod, Rodrigo Gutierrez-Quintana, Emer Curley, Karin Williams, Sandeep K. Chahal, Karen Strathdee, George E. Finney, Evarest Onwubiko, Angie Rupp, Katrina Stevenson, Mark R. Jackson, Anthony J. Chalmers
Publikováno v:
International Journal of Radiation Oncology, Biology, Physics
Purpose:\ud Low-dose whole lung radiotherapy (LDLR) has been proposed as a treatment for patients with acute respiratory distress syndrome associated with SARS-CoV-2 infection and clinical trials are underway. There is an urgent need for preclinical
Autor:
Nobuoki Kohno, Matthew Cunningham, Phillip P Lynch, Charles McSharry, Kenneth Boyd, Louise V. Wain, G Boyd, Iona Donnelly, Mark Spears, Yuan Ji, Stephen J. Bourke
Publikováno v:
Clinical & Experimental Allergy. 50:1391-1399
BACKGROUND Identifying early stages of hypersensitivity pneumonitis (HP) is hampered by variable presentation, heterogeneous or undetected causal antigens and lack of gold-standard biomarkers. Krebs von den Lungen (KL)-6 is pathophysiological biomark
Autor:
Nirupma Kakkar, Charles McSharry, Adrian Heaps, S Hasan, Sharon Cookson, Iona Donnelly, Agnieszka Jozwik, Stephen Todryk, Stephen J. Bourke
Publikováno v:
Allergy. 75:1469-1473
Pigeon Fancier's Lung (PFL) is a form of Hypersensitivity Pneumonitis where lung pathology occurs due to an immune reaction to repeated inhalation of large amounts of feather-derived and droppings-derived dust [1]. The 1μm dust particles penetrate t