Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Charles M. Schaub"'
Autor:
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot
Externí odkaz:
https://doaj.org/article/eb23a693600e41d29543c852619dfa62
Autor:
Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Karolina E. Zaborska, Charles M. Schaub, Matthew A. Brown, David A. Jacobson, Emma L. Duncan
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] muta
Externí odkaz:
https://doaj.org/article/33dbdc4478504d16946c60f7af11f097
Autor:
Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)
Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca
Externí odkaz:
https://doaj.org/article/739b7a2b2b794efa9353527289b42407
Autor:
Karolina E. Zaborska, Kelli L. Jordan, Ariel S. Thorson, Prasanna K. Dadi, Charles M. Schaub, Arya Y. Nakhe, Matthew T. Dickerson, Joshua C. Lynch, Adam J. Weiss, Jordyn R. Dobson, David A. Jacobson
Publikováno v:
Diabetes Obes Metab
AIM: To determine whether hyperpolarization-activated cyclic nucleotide-gated (HCN) channels impact glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) modulation of islet Ca(2+) handling and insulin secretion. METHODS: The impact of liraglutide (GLP-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fdab110582ef02ffb7bb0f51d09922
https://europepmc.org/articles/PMC9843726/
https://europepmc.org/articles/PMC9843726/
Autor:
Charles M. Schaub, Sarah M. Graff, Mhairi Marshall, Matthew T. Dickerson, Karolina E. Zaborska, Emma L. Duncan, Paul Leo, Stephanie R. Johnson, David A. Jacobson, Arya Y. Nakhe, Prasanna K. Dadi, Matthew A. Brown, Aideen M. McInerney-Leo
Publikováno v:
JCI Insight
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] muta
Autor:
Charles M. Schaub, Sarah M. Graff, Roy S. Kondapavuluru, Matthew T. Dickerson, Prasanna K. Dadi, Arya Y. Nakhe, Jerod S. Denton, Jade E. Stanley, Karolina E. Zaborska, Ariel S. Thorson, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 42, Iss, Pp 101056-(2020)
Molecular Metabolism
Molecular Metabolism
Objective Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monocar
Autor:
Arya Y. Nakhe, Karolina E. Zaborska, David A. Jacobson, Prasanna K. Dadi, Charles M. Schaub, Sarah M. Graff, Matthew T. Dickerson, Regan B. Butterworth
Publikováno v:
J Physiol
Key points Tetraspanin (TSPAN) proteins regulate many biological processes, including intracellular calcium (Ca2+ ) handling. TSPAN-7 is enriched in pancreatic islet cells; however, the function of islet TSPAN-7 has not been identified. Here, we char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc42d8ff3afd81f023641b9c129d55e
https://europepmc.org/articles/PMC8095317/
https://europepmc.org/articles/PMC8095317/
Autor:
Thomas J. Galletta, Prasanna K. Dadi, Ariel S. Thorson, Guoqiang Gu, Gautami Amarnath, David A. Jacobson, Charles M. Schaub, Matthew T. Dickerson, Molly K. Altman, Sarah M. Graff
The melastatin subfamily of the transient receptor potential channels (TRPM) are regulators of pancreatic β-cell function. TRPM7 is the most abundant islet TRPM channel; however, the role of TRPM7 in β-cell function has not been determined. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ca3ee2eaac69c7dd64ee81e19168040
https://doi.org/10.1101/2020.07.15.204974
https://doi.org/10.1101/2020.07.15.204974
Autor:
Kenneth R. Prestwich, David L. Smith, Gerald J. Rohwein, Guy L. Donovan, Roy A. Hamil, Charles M. Schaub
Publikováno v:
SPIE Proceedings.
Power oscillator circuit modeling and redesign for the Particle BeamFusion Accelerator II (PBFA -II) switch trigger laserDavid L. Smith, Roy A. Hamil, Kenneth R. PrestwichGerald J. Rohwein, Guy L. Donovan, and Charles M. SchaubSandia National Laborat
Conference
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