Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Charles M. Roco"'
Autor:
Tanya Grancharova, Kaytlyn A. Gerbin, Alexander B. Rosenberg, Charles M. Roco, Joy E. Arakaki, Colette M. DeLizo, Stephanie Q. Dinh, Rory M. Donovan-Maiye, Matthew Hirano, Angelique M. Nelson, Joyce Tang, Julie A. Theriot, Calysta Yan, Vilas Menon, Sean P. Palecek, Georg Seelig, Ruwanthi N. Gunawardane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract We performed a comprehensive analysis of the transcriptional changes occurring during human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using single cell RNA-seq, we sequenced > 20,000 single cells from 55 indepe
Externí odkaz:
https://doaj.org/article/d4fb933e376547c486f87bcf5fd17339
Autor:
William B. Dobyns, Georg Seelig, Lynne M. Overman, Forrest O. Gulden, Ian A. Glass, Andrew E. Timms, Ian G. Phelps, Matthew Hirano, Paula Alexandre, Alexander B. Rosenberg, Kathleen J. Millen, Gabriel Santpere, Dan Doherty, Steven Lisgo, Charles M. Roco, Mei Deng, Parthiv Haldipur, Zachary Thomson, Kimberly A. Aldinger, Belen Lorente-Galdos, Diana R. O’Day, Nenad Sestan
Publikováno v:
Nature neuroscience
The human neonatal cerebellum is one-fourth of its adult size yet contains the blueprint required to integrate environmental cues with developing motor, cognitive and emotional skills into adulthood. Although mature cerebellar neuroanatomy is well st
Autor:
Vuong Tran, Efthymia Papalexi, Sarah Schroeder, Grace Kim, Ajay Sapre, Joey Pangallo, Alex Sova, Peter Matulich, Lauren Kenyon, Zeynep Sayar, Ryan Koehler, Daniel Diaz, Archita Gadkari, Kamy Howitz, Maria Nigos, Charles M. Roco, Alexander B. Rosenberg
Single cell RNA sequencing (scRNA-seq) has become a core tool for researchers to understand biology. As scRNA-seq has become more ubiquitous, many applications demand higher scalability and sensitivity. Split-pool combinatorial barcoding makes it pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68b5256d8f4d4ac6ee5d5d0061be7637
https://doi.org/10.1101/2022.08.27.505512
https://doi.org/10.1101/2022.08.27.505512
Autor:
Kaylee Park, Georg Seelig, Robert J. Hopkin, Steven Lisgo, Joseph G. Gleeson, Yuri A. Zarate, Charles E. Schwartz, Stephen R. Braddock, Katherine Wusik, Zachary Thomson, Deborah A. Nickerson, Charles M. Roco, Susan Sell, Jordan Zeiger, Chi V. Cheng, Matthew Hirano, Julie R. Jones, Roger L. Ladda, Gisele E. Ishak, Amy Goldstein, David B. Everman, Dan Doherty, Sarah Collins, William B. Dobyns, Lynne M. Overmann, Ian A. Glass, Alexander B. Rosenberg, Megan T. Cho, Kathleen A. Leppig, Kimberly A. Aldinger, Brian H.Y. Chung, Andrew E. Timms, Kathleen J. Millen, Fatima Abidi, Michael J. Bamshad, Cynthia J. Curry, Fowzan S. Alkuraya, A. James Barkovich, James T. Bennett, Parthiv Haldipur, Leslie G. Biesecker, Ian D. Krantz, Ghayda M. Mirzaa, Dianne Gerrelli, Barbara McGillivray, Sara S. Cathey
Publikováno v:
The American Journal of Human Genetics. 105:606-615
Cerebellar malformations are diverse congenital anomalies frequently associated with developmental disability. Although genetic and prenatal non-genetic causes have been described, no systematic analysis has been performed. Here, we present a large-e
Autor:
Ruwanthi N. Gunawardane, Angelique M. Nelson, Matthew Hirano, Stephanie Q. Dinh, Julie A. Theriot, Joyce Tang, Sean P. Palecek, Alexander B. Rosenberg, Joy Arakaki, Vilas Menon, Tanya Grancharova, Calysta Yan, Rory Donovan-Maiye, Georg Seelig, Colette M. DeLizo, Charles M. Roco, Kaytlyn A. Gerbin
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
We performed a comprehensive analysis of the transcriptional changes within and across cell populations during human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using the single cell RNA-seq combinatorial barcoding method
Autor:
Paula Alexandre, Belen Lorente-Galdos, Diana R. O’Day, Alexander B. Rosenberg, Ian A. Glass, Parthiv Haldipur, Nenad Sestan, Zach Thomson, Charles M. Roco, William B. Dobyns, Kimberly A. Aldinger, Gabriel Santpere, Dan Doherty, Matthew Hirano, Steven Lisgo, Lynne M. Overman, Mei Deng, Andrew E. Timms, Kathleen J. Millen, Forrest O. Gulden, Georg Seelig
Cerebellar development and function require precise regulation of molecular and cellular programs to coordinate motor functions and integrate network signals required for cognition and emotional regulation. However, molecular understanding of human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973ae4c2edc3a36c440ed02aed6d7afb
https://doi.org/10.1101/2020.06.30.174391
https://doi.org/10.1101/2020.06.30.174391
Autor:
Ruwanthi N. Gunawardane, Kimberly R. Cordes Metzler, Angelique M. Nelson, Georg Seelig, M. Filip Sluzewski, Jamie L. Gehring, Melissa C. Hendershott, Theo A. Knijnenburg, Sean P. Palecek, Charles M. Roco, Kaytlyn A. Gerbin, Stephanie Q. Dinh, Jackson M. Brown, Aditya Nath, Gregory R. Johnson, Julie A. Theriot, Matthew Hirano, Vilas Menon, Tanya Grancharova, Susanne M. Rafelski, Nathalie Gaudreault, Alexander B. Rosenberg, Rebecca J. Zaunbrecher, Calysta Yan, Rory Donovan-Maiye, Matheus P. Viana
SummaryWe present a quantitative co-analysis of RNA abundance and sarcomere organization in single cells and an integrated framework to predict subcellular organization states from gene expression. We used human induced pluripotent stem cell (hiPSC)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e326e27fbf7fc65e085222dc6bf70aa
https://doi.org/10.1101/2020.05.26.081083
https://doi.org/10.1101/2020.05.26.081083
Autor:
Ryan Kibler, Anna Kuchina, Georg Seelig, R. William DePaolo, Alexander B. Rosenberg, Luana Paleologu, Matthew Hirano, Alberto Carignano, Charles M. Roco, Leandra M. Brettner
Publikováno v:
Science
Bacterial cell gene expression Single-cell genomics in bacteria has lagged relative to in eukaryotes because of their tough bacterial cell walls, low messenger RNA content, and lack of many posttranscriptional modifications. To tackle this challenge,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d632cfe3f32526162b61539f583df1
https://doi.org/10.1101/869248
https://doi.org/10.1101/869248
Autor:
Georg Seelig, David J. Peeler, Alexander B. Rosenberg, Paul J Sample, Zizhen Yao, Richard A. Muscat, Charles M. Roco, Suzie H. Pun, Anna Kuchina, Wei Chen, Drew L. Sellers, Lucas T. Graybuck, Sumit Mukherjee, Bosiljka Tasic
Publikováno v:
Science
Identifying single-cell types in the mouse brain The recent development of single-cell genomic techniques allows us to profile gene expression at the single-cell level easily, although many of these methods have limited throughput. Rosenberg et al. d
Autor:
David J. Mooney, Christine A. Cezar, James C. Weaver, Herman H. Vandenburgh, Alizée Déléris, Stephen Kennedy, Charles M. Roco, Patrizia M. Spoerri
Publikováno v:
Biomaterials. 161:179-189
While providing the ability to magnetically enhance delivery rates, ferrogels have not been able to produce the various types of regulated delivery profiles likely needed to direct complex biological processes . For example, magnetically triggered re