Zobrazeno 1 - 10 of 181 pro vyhledávání: '"Charles M. Marson"'
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Akademický článek
A distal regulatory region of a class I human histone deacetylase
Autor: Nicolas D. Werbeck, Vaibhav Kumar Shukla, Micha B. A. Kunze, Havva Yalinca, Ruth B. Pritchard, Lucas Siemons, Somnath Mondal, Simon O. R. Greenwood, John Kirkpatrick, Charles M. Marson, D. Flemming Hansen
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Human Histone Deacetylases (HDACs) regulate gene expression and are important drug targets. Here, the authors combine NMR measurements, enzymatic assays and molecular dynamics simulations and show that HDAC8 samples a catalytically active and an inac
Externí odkaz: https://doaj.org/article/e6e3823b97f04066b0453b2d183e0a76
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A distal regulatory region of a class I human histone deacetylase
Autor: Lucas Siemons, Vaibhav Kumar Shukla, Havva Yalinca, Micha B. A. Kunze, Ruth B. Pritchard, Charles M. Marson, Nicolas D. Werbeck, Somnath Mondal, John Kirkpatrick, D. Flemming Hansen, Simon O. R. Greenwood
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Histone deacetylases (HDACs) are key enzymes in epigenetics and important drug targets in cancer biology. Whilst it has been established that HDACs regulate many cellular processes, far less is known about the regulation of these enzymes themselves.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb020fcb612a7bfdd48bafb085624bc1
http://link.springer.com/article/10.1038/s41467-020-17610-w
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7
Monocyclic Quinone Structure‐Activity Patterns: Synthesis of Catalytic Inhibitors of Topoisomerase II with Potent Antiproliferative Activity
Autor: Thomas M. Waugh, John R. W. Masters, Abil E. Aliev, Charles M. Marson
Publikováno v: ChemMedChem. 15:114-124
The monocyclic 1,4-benzoquinone, HU-331, the direct oxidation product of cannabidiol, inhibits the catalytic activity of topoisomerase II but without inducing DNA strand breaks or generating free radicals, and unlike many fused-ring quinones exhibits
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c812b50f32106427d0da56e455a5d1
https://doi.org/10.1002/cmdc.201900548
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8
A stepwise lactol carbocyclisation to bridged ethers via a keto–acetal cascade
Autor: Sean McCarthy, Charles M Marson
Publikováno v: Journal of Chemical Research. 46:174751982210794
Lactol carbocyclisations provide a succinct method of constructing the oxabicyclo[3.2.1]octane scaffold, a motif present in various natural products of medicinal interest. Lactols containing an unsaturated ketone or ester were prepared by olefin cros
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39cf4fc334f1b7f19b7280e0b2269b06
https://doi.org/10.1177/17475198221079498
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9
Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an α-amino amide as the zinc-binding unit
Autor: Simon O. R. Greenwood, D. Flemming Hansen, Charles M. Marson, A.W. Edith Chan
Publikováno v: Bioorganicmedicinal chemistry letters. 30(5)
A series of potent inhibitors of histone deacetylase-8 (HDAC8) is described that contains an α-amino amide zinc-binding unit and a substituted isoindolinyl capping group. The presence of a 2,4-dichlorophenyl unit located in the acetate-release cavit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937fe0ed6a266fdcdd1c2a229588a284
https://pubmed.ncbi.nlm.nih.gov/31952961
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10
Domino Michael-aldol annulations for the stereocontrolled synthesis of bicyclo[3.3.1]nonane and bicyclo[3.2.1]octane derivatives
Autor: Charles M. Marson, Jean-Alexandre Richard, Rossella Promontorio
Publikováno v: RSC Advances. 6:114412-114424
Domino Michael-aldol annulation of cycloalkane-1,3-diones with enals affords a general route to 6-hydroxybicyclo[3.3.1]nonane-2,9-diones and 2-hydroxybicyclo[3.2.1]octane-6,8-diones, notably in one-pot procedures under convenient conditions. The annu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::340b396c2ef912354402e605ff1d1d8f
https://doi.org/10.1039/c6ra23523a
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