Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Charles M. Deber"'
Autor:
Shelley He, Charles M. Deber
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The outer membrane (OM) is a hallmark feature of gram-negative bacteria that provides the species with heightened resistance against antibiotic threats while cationic antimicrobial peptides (CAPs) are natural antibiotics broadly recognized f
Externí odkaz:
https://doaj.org/article/7a09ef3d562643618f2d9cc31b1f0048
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2170 (2024)
Vacuolar ATPases (V-ATPases), proton pumps composed of 16 subunits, are necessary for a variety of cellular functions. Subunit “a” has four isoforms, a1–a4, each with a distinct cellular location. We identified a phosphoinositide (PIP) interact
Externí odkaz:
https://doaj.org/article/4d7705eff4974f0299322ffff43f505d
Autor:
Anh Chu, Yeqi Yao, Golam T. Saffi, Ji Hyun Chung, Roberto J. Botelho, Miroslawa Glibowicka, Charles M. Deber, Morris F. Manolson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4867 (2023)
Vacuolar ATPases (V-ATPases) are multi-subunit ATP-dependent proton pumps necessary for cellular functions, including pH regulation and membrane fusion. The evidence suggests that the V-ATPase a-subunit’s interaction with the membrane signaling lip
Externí odkaz:
https://doaj.org/article/36bf4037a564495d8d0aeeeefd4a8e81
Autor:
Trevor Beaudoin, Tracy A. Stone, Miroslawa Glibowicka, Christina Adams, Yvonne Yau, Saumel Ahmadi, Christine E. Bear, Hartmut Grasemann, Valerie Waters, Charles M. Deber
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract With the increasing recognition of biofilms in human disease, the development of novel antimicrobial therapies is of critical importance. For example, in patients with cystic fibrosis (CF), the acquisition of host-adapted, chronic Pseudomona
Externí odkaz:
https://doaj.org/article/1d3bcf416aa84b6eb2bf558f5d4620b3
Publikováno v:
Biomolecules, Vol 10, Iss 2, p 334 (2020)
Chronic infection and inflammation are the primary causes of declining lung function in Cystic Fibrosis (CF) patients. ORKAMBI® (Lumacaftor-Ivacaftor) is an approved combination therapy for Cystic Fibrosis (CF) patients bearing the most common mutat
Externí odkaz:
https://doaj.org/article/6491dc1303054428a423e91470cdbda2
Publikováno v:
Biochemical and Biophysical Research Communications. 612:105-109
While cationic antimicrobial peptides (CAPs) are compelling candidates for antimicrobial therapy, their clinical development is largely hampered by their rapid and non-specific enzymatic degradation in physiological fluids. We have earlier de novo de
Publikováno v:
Biochemistry. 60:2586-2592
Peptides with a combination of high positive charge and high hydrophobicity have high antimicrobial activity, as epitomized by peptide venoms, which are designed by nature as disruptors of host membranes yet also display significant efficacy against
Publikováno v:
Biophysical journal. 121(17)
As the bacterial multidrug resistance crisis continues, membrane-active antimicrobial peptides are being explored as an alternate treatment to conventional antibiotics. In contrast to antimicrobial peptides, which function by a nonspecific membrane d
Autor:
Mathias Schenkel, Dorna Ravamehr-Lake, Tomasz Czerniak, James P. Saenz, Georg Krainer, Michael Schlierf, Charles M. Deber
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865:184078
Cystic fibrosis (CF) is caused by mutations in the gene that codes for the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR). Recent advances in CF treatment have included use of small-molecule drugs known as modulators, suc
Publikováno v:
Protein Science : A Publication of the Protein Society
Membrane proteins play key roles in cellular signaling and transport, represent the majority of drug targets, and are implicated in many diseases. Their relevance renders them important subjects for structural, biophysical, and functional investigati